Studies on the Constituents of the Bark of &lt;i&gt;Engelhardtia formosana&lt;/i&gt; HAY. X

Tominaga, Toshio; Yoshimura, Kazunari

doi:10.1248/yakushi1947.80.10_1345

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“…The bark and the leaves are also used as fish poison [3]. Past studies have revealed dihydroflavonol glycosides and flavonol glycosides to be the major constituents of leaves and stem bark of this species [4], [5], [6]. Examination of the root has led to the isolation of three new (1 ± 3) and twelve known compounds.…”

Section: Introductionmentioning

confidence: 99%

Antitubercular Constituents from the Roots ofEngelhardia roxburghiana

Lin

Tsai

et al. 2005

Planta med

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Three new compounds, engelhardione, (-)-5-hydroxy-4-methoxy-1-tetralone, and 3-methoxycarbonyl-1,5-dihydroxyanthraquinone, together with twelve known compounds have been isolated from the roots of Engelhardia roxburghiana. The structures of these new compounds were determined through spectral analyses. Engelhardione, 3-methoxyjuglone, and (-)-4-hydroxy-1-tetralone showed antitubercular activities with MIC values=3.125, 3.125, and 6.25 microg/mL against Mycobacterium tuberculosis 90-221,387, respectively, and with MIC values=0.2, 0.2, and 4.0 microg/mL against M. tuberculosis H37Rv, individually.

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