Studies on the blocking antibody in serum of ragweed-treated patients

Asthma, Allergy and Immunotherapy; A Historical Review: Part II

“…Additionally, the development of heightened titers of neutralizing antibody in the absence of objective benefit added to evidence of previous reports that cast doubt on the clinical relevance of engendered "blocking" immune factor. 143,144 Meanwhile, Loveless in 1947 initiated a clinical trial of repository therapy145which reported highly favorable results 10 years later l46 and served as the stimulus for the first departure from conventional injection treatment plans. Despite contrary opinion, Loveless remained firm in her original belief that successful response to treatment was a function of the "blocking" properties of induced neutralizing factor.…”