Studies on the bioactive flavonoids isolated from <i>Azadirachta indica</i>

Cen-Pacheco, Francisco; Ortiz-Celiseo, Araceli; Peniche-Cardeña, Álvaro; Bravo-Ruiz, Omar; López-Fentanes, Fernando C.; Valerio‐Alfaro, Gerardo; Fernández, José J.

doi:10.1080/14786419.2019.1579808

Cited by 8 publications

(6 citation statements)

References 18 publications

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“…In effect, lipophilicity is one of the most important physical properties in drug discovery, since it intervenes in the pharmacodynamics, pharmacokinetics, and toxicity of many compounds (43) . For example, Echeverría et al (44) and Cen-Pacheco et al (24) reported that the bactericide and acaricidal activity of the flavonoids is associated with a narrow range of lipophilicity values (LogP between 1.5 and 3.0).…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, compounds 1-11 were tested at a concentration of 6 mM. The final volume used in the larval immersion test was 750 μL, whereas in the adult immersion test it was 5 mL (24) .…”

Section: Concentration Of the Tested Samplesmentioning

confidence: 99%

“…Azadirachta indica A. Juss, commonly known as the "neem" tree in Latin America, is a wellknown curative plant with a wide range of pharmacological activities and beneficial health properties (18)(19)(20) . A variety of metabolites with high structural diversity have been isolated from the "neem" tree, some of which have shown important bioactivities, like antioxidant, cytotoxic, bactericide or larvicide effects (21)(22)(23)(24) . This study evaluates the acaricidal activity of 18 extracts from Mexican plants, against larvae and engorged ticks of R. microplus.…”

Section: Introductionmentioning

confidence: 99%

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Acción ixodicida de productos naturales de plantas nativas mexicanas

Sosa-Rueda

Villarauz

Domínguez-Meléndez

et al. 2023

Rev. Mex. Cienc. Pecu.

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This work determined the acaricidal effect of 18 Mexican plants against Rhipicephalus microplus. The results of the larvicidal assay revealed that 5 methanolic extracts produced high activity (86-100 % mortality), 3 extracts exhibited relatively high activity (71-85 % mortality), 2 extracts displayed moderate activity (56-70 % mortality), 2 extracts presented low activity (31-55 % mortality) and 6 extracts showed non-significant acaricidal activity (0-30 % mortality). Extracts inducing >56 % mortality were subsequently assayed against engorged ticks of R. microplus by adult immersion test at a concentration of 5.0% w/v. In general terms, the results on larvae and adult ticks indicated that the methanolic extracts of Annona globiflora, Annona scleroderma, Litchi chinensis and Azadirachta indica showed the greatest activities. The crude extract of A. indica was subjected to chromatographic purification, which has led to the isolation of 3-O-butyl-(-)-epigallocatechin (1), 3-O-butyl-(-)-epicatechin (2), (-)-epigallocatechin (3), (+)-gallocatechin (4), (-)-epicatechin (5), β-sitosterol (6), stigmasterol (7), stigmasterol glucoside (8), triolein (9), azadirachtin A (10), and the octadecanoic acid-tetrahydrofuran-3,4-vinyl ester (11). The isolated compounds' chemical structures were identified by the interpretation of NMR and HRESI-MS spectroscopic data. The isolated compounds were assayed against engorged ticks of R. microplus at a concentration of 6 mM. Based on the results obtained, it was concluded that 3-O-butyl-(-)-epigallocatechin (1), 3-O-butyl-(-)-epicatechin (2), azadirachtin A (10), and octadecanoic acid-tetrahydrofuran-3,4-vinyl ester (11) show the highest effectiveness.

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Section: Discussionmentioning

confidence: 99%

Section: Concentration Of the Tested Samplesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Acción ixodicida de productos naturales de plantas nativas mexicanas

Sosa-Rueda

Villarauz

Domínguez-Meléndez

et al. 2023

Rev. Mex. Cienc. Pecu.

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“…Additionally, the powdered leaves are combined with water and used to treat freckles on the face, increase hunger by reducing stomach gas production and eradicating intestinal worms [21]. Te bioactive favonoids were isolated from neem tree bark and were tested for acaricidal activity with a LD50 value less than 7.2 mM [22]. Apart from medicinal applications, the neem parts are also tested for its insecticidal property [23,24].…”

Section: Introductionmentioning

confidence: 99%

GC-MS Phytochemical Profiling, Antidiabetic, and Antioxidant Activities of Khaya senegalensis Stem Bark and Azadirachta indica Leaves Extracts in Rats

Ahmed

Khalid

Mohan

et al. 2023

Journal of Spectroscopy

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This study was performed to evaluate phytochemical composition of Khaya senegalensis stem bark and Azadirachta indica leaf hydroethanolic (80%) extracts using GC-MS technique as a tentative identification method and screen for antioxidant and antidiabetic properties in Wistar rats. Diabetes was induced by intraperitoneal injection of alloxan (150 mg/kg·bw). Animals were divided into groups of six and treated by extracts (400 mg/kg·bw) for 28 days. The results compared with positive and negative control groups of animals. After treatment, blood samples were collected to determine the blood glucose level, lipid profile, liver and kidney function markers, and DPPH free radical scavenging activity was evaluated. Phytochemical investigations revealed that extracts were enriched with a wide range of secondary metabolites such as phenols, saponins, triterpenes, alkaloids, flavonoids, sterols, fatty acids, siloxane derivatives, and anthraquinones in diverse concentrations with reported antioxidant and antidiabetic properties. Biological screening results indicated that both extracts exhibited free-radical scavenging property in DPPH screening, and in that, K. senegalensis stem bark extract (91 ± 0.02%) showed greater reduction than A. indica leaf extract (55 ± 0.03%), with an IC50 of 0.023 ± 0.03 g/mL, which was lower than the reference drug propylgallate (0.077 ± 0.03 g/mL). Both the extracts remarkably reduced the blood glucose concentration in diabetic rats ( p < 0.05 ). However, A. indica leaf extract showed greater reduction (52%) than K. senegalensis stem bark extract (37%). Similarly, the cholesterol, LDL, triglyceride, total protein, albumin, urea, creatinine, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) levels decreased significantly ( p < 0.05 ), in comparison to diabetic control animals. However, the concentrations of HDL slightly increased. Overall, both extracts showed significant antidiabetic and antioxidant potential in diabetic rats. As oxidative stress is associated with the hyperglycemia, the antioxidant activity displayed by the extracts will provide additional benefits in the antidiabetic therapy.

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“…Medicinal potential of the tree can be attributed to various diverse nature of secondary metabolites/bioactives, that is, terpenes [13], limonoids [14], flavonoids [15], alkaloids [16], and saponins [17], which mediated their role by affecting various biological processes.…”

Section: Introductionmentioning

confidence: 99%

A Systematic Review of Terpenoids in Azadirachta indica: Classes, Structures and Medicinal Uses

Awadh

Kahindo²,

Swaleh³

et al. 2022

CSIJ

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Azadirachta indica (neem) can be considered as “Nature’s Chemist” due to its therapeutic, pharmaceutical, agro and medicinal properties. Neem tree is the most researched tree so far and has proven to be the most prospect target for the future drug discoveries. Its bioactivity has been associated with vast richness in phytochemicals whereas the terpenoids are the major medicinal components. Terpenoids are classified into different categories which display a wide range of biological activities. This article reviews the terpenoids reported in different parts of neem tree, classes, structures, their usage and application in modern medicine.

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Studies on the bioactive flavonoids isolated from Azadirachta indica

Cited by 8 publications

References 18 publications

Acción ixodicida de productos naturales de plantas nativas mexicanas

Acción ixodicida de productos naturales de plantas nativas mexicanas

GC-MS Phytochemical Profiling, Antidiabetic, and Antioxidant Activities of Khaya senegalensis Stem Bark and Azadirachta indica Leaves Extracts in Rats

A Systematic Review of Terpenoids in Azadirachta indica: Classes, Structures and Medicinal Uses

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