Studies on the antitumor activity of complexes of R2Sn(IV) with penicillamine enantiomers and with 3-thio-propanoic acid, and correlation with structural aspects

119mSn Mössbauer studies on tin compounds

“…Besides, in the context of studies on the antitumor activity of organotin(IV) derivatives [196,197], the composition of species in the vehicle of administration (e.g. in mice) has been investigated by this technique, in order to obtain detailed information on the relationship between structure and antitumor activity [171,[198][199][200][201].…”

Chemical Processes in Marine Environments

“…Polypeptides bind also to toroidal DNA condensates (Reich et al 1990). In this context, the interaction of organotins with nucleic acid in the presence of amino acids has been investigated by 119Sn Mossbauer spectroscopy, and the results obtained are reported in Table 12.6 (Barbieri 1995 Barbieri and Musmeci 1988;Barbieri et al 1990). Then, the complexes above do not interact with DNA in systems 1, From the experimentation summarized in Table 12.6, it would then appear that moieties Alk1Sn(IV) (which show a pronounced tendency to bind to DNA phosphodiester, Table 12.2) do not interact with DNA when coordinated by thiol sulfur in aqueous solution, even if a partial positive charge may be supposed to persist on tin (Silvestri et al 1988; Barbieri and Musmeci 1988); in this context, it is worth mentioning that MezSn[SCH1CH(NH1)COO] reacts with a further cysteine thiol sulfur in rat hemoglobin (Barbieri and Musmeci 1988).…”

Diorganotin(IV) N-acetyl-l-cysteinate complexes: Synthesis, solid state, solution phase, DFT and biological investigations

“…The interaction of organotin(IV) compounds towards D-and Lpenicillamine, reduced GSH, L-cysteine, S-methyl-L-cysteine and H 2 NAC has been investigated, both in aqueous solution [23][24][25][26] and in solid state [27,28]. H 2 NAC (Fig.…”