Studies on the Antioxidant and Cytotoxic Potentials of the Peel Extract of Dacryodes rostrata

Abstract

Breast cancer is one type of cancer that causes the highest death in women in Indonesia. Alternative herbal-based cancer treatments have been developed, one of which is using fruits. Dacryodes rostrata, a fruit commonly consumed by residents in Kalimantan, is rich in antioxidants such as flavonoids and phenolics. The purpose of this study was to determine the value of antioxidant and cytotoxic activity of water and ethanol extract of D. rostrata peel against T-47D breast cancer cell lines. The fruit extraction was carried out by using maceration method. Antioxidant activity test using 2,2-diphenyl-1-picrylhydrazyl (DPPH) method and cytotoxic test using MTT method (3-(4,5-dimethylthiazole-2-yl)-2,5-diphenitetrazolium bromide) assay. The results showed that D. rostrata water and ethanol extract had antioxidant activity with IC50 values 121.7 ppm and 59.27 ppm, respectively. While cytotoxic effect on T-47D cells with IC50 values of 322.55 ppm and 143.02 ppm, respectively. This study showed that D. rostrata peel water extract had moderate antioxidant activity and moderate cytotoxic effect against T-47D breast cancer cells in vitro which could be used as a chemo preventive to prevent and inhibit cancer cell growth.

The Genus Dacryodes Vahl.: Ethnobotany, Phytochemistry and Biological Activities

“… Countries with reports of Dacryodes species. Pink = South American species like as D. excelsa and D. peruviana , green = African species such as D. edulis and D. klaineana , yellow = Southeast Asian species such as D. rostrata and D. costata [ 15 , 17 , 26 , 31 , 32 , 34 , 36 , 42 , 67 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 ]. …”

“…The well-known "Safou" are produced and commercialized in Cameroon for the lo- Dacryodes rostrata is widely found in Malaysia, more precisely in the region of Sabah, Sarawak [34] and on Borneo Island [15,32,36]. It is an Indonesian endemic fruit tree originating in Kalimantan and found in all districts throughout West Kalimantan [72]. In addition, it is also found in Thailand, Indo-China, Sumatra, Sulawesi, the Philippines [31] and Singapore [73].…”