Studies on the antioxidant activities of some new chromone compounds

Abstract

Recent reviews evidence that the naturally occurring compounds containing the chromone skeleton exhibit antiradical activities, providing protection against oxidative stress. The antioxidant activities of 13 new synthesized chromonyl-2,4-thiazolidinediones, chromonyl-2,4-imidazolidinediones and chromonyl-2-thioxoimidzolidine-4-ones were evaluated using in vitro antioxidant assays, including superoxide anion radical (O2(-•)), hydroxyl radical (HO(•)), 2,2-diphenyl-1-picryl-hydrazyl free radical (DPPH(•)) scavenging capacity and total antioxidant capacity ferric ion reducing activity. Superoxide anion radical was produced using potassium superoxide/18-crown-6-ether dissolved in dimethylsulfoxide, and the Fenton-like reaction (Fe(II) + H2O2) was a generator of hydroxyl radicals. Chemiluminescence, spectrophotometry, electron paramagnetic resonance (EPR) and 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) as the spin trap were the measurement techniques. The results showed that the majority of the chromone derivatives tested showed a strong scavenging effect towards free radicals, similar to the chemiluminescence reaction with superoxide anion radical with a high activity, inhibition of the DMPO-OOH radical EPR signal (24-58%), the DMPO-OH radical EPR signal (4-75%) and DPPH radical EPR signal (6-100%) at 1 mmol/L. Several of the examined compounds exhibited the high reduction potentials. The results obtained show that the new synthesized chromone derivatives may directly scavenger reactive oxygen species and thus may play a protective role against oxidative damage.

A novel sulfonyl chromen‐4‐ones (CHW09) preferentially kills oral cancer cells showing apoptosis, oxidative stress, and DNA damage

“…Both 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) and 2,2‐azinobis (3‐ethyl‐benzothiazoline‐6‐sulfonic acid) (ABTS) scavenging activities of CHW09 are 10% at 100 μg/mL (data not shown), suggesting the CHW09 has antioxidant properties. This antioxidant effect is consistent to other chromones . It is noted that several antioxidants have both ROS reducing and inducing effects for low and high concentrations.…”

“…Chromones are oxygen‐containing heterocyclic compounds known for their antioxidant properties . Some chromone derivatives also show reactive oxygen species (ROS) and reactive nitrogen species (RNS) scavenging activities .…”

Review of future insights of Dragon's Blood in dermatology

“…The first formulation, called mixture of antioxidant and moisturizer (MAM), was a mixture of Rosa moschata , C. lechleri , Aloe vera , and D‐panthenol (moisturizer). The second formulation was 2% hydroglycolic solution of disodium cromoglycate (CGDS), which is an efficacious free radical scavenger and inhibitor (Kladna et al, ). The final two formulations were Formulation A, a mixture of MAM and CGDS 2%, and Formulation B, a mixture of MAM and CGDS 5%.…”

A Nonsteroidal Novel Formulation Targeting Inflammatory and Pruritus-Related Mediators Modulates Experimental Allergic Contact Dermatitis

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