Review of future insights of Dragon's Blood in dermatology

Abstract

To assess the possible clinical implication of Dragon's Blood in dermatology, a PubMed search was conducted using the keyword “Dragon's Blood,” “Croton lechleri,” and more. Dragon's Blood from C. lechleri is an Amazonian medicinal plant with a characteristic red sap. Its array of phytochemical action in preclinical studies include anti‐inflammatory, antioxidant, antimicrobial, antifungal, and antineoplastic properties. Clinical studies reflect wound healing and antiviral properties. Although its popularity is rising in western medicine, C. lechleri offers limited use in dermatology and further investigation is necessary to gain further insight into its potential clinical implication.

Mangiferin-Loaded Polymeric Nanoparticles: Optical Characterization, Effect of Anti-topoisomerase I, and Cytotoxicity

“…It has been shown that during the development of a carcinoma, there is an increase in topoisomerases, because these enzymes are involved in cell replication [37]. Previous studies confirmed that mangiferin is capable of inhibiting the topoisomerase I enzyme (Topo I), involved in the splitting of DNA during cell division [38], Therefore, for this study, it was considered to evaluate its activity on Topo I in order to evaluate if there is loss of biological power or if it can be increased due to the controlled release of MG. Due to this, the used JN394 genetically modified strain (Matα ura3-52, leu2, trp1, his7, ade1-2, ISE2, rad52::LEU2) promotes a deficiency in the regeneration of DNA, greater permeability in the cell membrane y JN362a (Matα, ura3-52, leu2, trp1, his7, ade1-2, ISE2) resistant to DNA repair but sensitive to antimicrobial agents.…”

Dracorhodin perchlorate enhances wound healing via β‑catenin, ERK/p38, and AKT signaling in human HaCaT keratinocytes

“…Dracorhodin is originally the fruit extract of dragon blood, which can be used as a TCM (2,10). Dragon blood confers a number of bioactivities, including antibacterial, anti-diarrheal, anti-inflammatory, anti-oxidant, antitumor, anti-ulcer, antiviral, immune-modulatory and wound healing functions (1). Previous studies have demonstrated that dragon blood can promote the proliferation of fibroblasts, increase the ratio of cells in the S-phase of the cell cycle and collagen formation, in addition to enhancing wound healing (1,11,12).…”

“…Dragon blood confers a number of bioactivities, including antibacterial, anti-diarrheal, anti-inflammatory, anti-oxidant, antitumor, anti-ulcer, antiviral, immune-modulatory and wound healing functions (1). Previous studies have demonstrated that dragon blood can promote the proliferation of fibroblasts, increase the ratio of cells in the S-phase of the cell cycle and collagen formation, in addition to enhancing wound healing (1,11,12). In the present study, dracorhodin perchlorate was found to significantly promote wound healing in human HaCaT keratinocytes.…”

“…Dragon blood is a type of deep-red resin that has been used as a form of traditional medicine worldwide since ancient times (1). Families of plants with the ability to produce dragon blood can be classified into four different categories: Asparagaceae, Arecaceae, Chamaesyce and Fabaceae (Table I) (2)(3)(4).…”

“…Dragon blood has been included in recipes for wound treatment in various ancient traditional Chinese medical guides of the 14-18th century (6). Accumulating evidence has also indicated that dragon blood possesses wound healing activities both in vivo and in vitro (1,(11)(12)(13). Accordingly, a previous study showed that the herbal complex 'Jinchuang Ointment' can successfully treat non-healing wounds on patients with diabetes, where dragon blood from D. draco is one of the components (2.1%) in this ointment (14).…”