Studies on the Antioxidant Activities of Total Alkaloids from the Fruits of &lt;i&gt;Evodia rutaecarpa&lt;/i&gt; &lt;i&gt;(Juss.)&lt;/i&gt; Benth

Tan, Ming X.; Liu, Yan Cheng; Luo, Xu Jian; Li, Dong Qing

doi:10.4028/www.scientific.net/amr.396-398.52

Cited by 7 publications

(4 citation statements)

References 6 publications

(4 reference statements)

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“…In the present study, 15 weeks of JKW administration significantly reduced lipid peroxidation and triglyceride and cholesterol accumulations in mice liver. The antioxidant activities of S. baicalensis and E. rutaecarpa [28, 37] might also contribute to the observed effects of JKW. In addition, JKW supplementation reduced hepatic damage caused by lipid accumulation and enhanced the activities of the liver enzymes GOT and GPT.…”

Section: Discussionmentioning

confidence: 99%

Jwa Kum Whan Attenuates Nonalcoholic Fatty Liver Disease by Modulating Glucose Metabolism and the Insulin Signaling Pathway

Lim

Kim

Lee

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Over the last decade, the link between nonalcoholic fatty liver disease (NAFLD) and insulin resistance has attracted considerable attention. Caused by chronic hyperglycemic stress, insulin resistance (IR) impairs insulin signal transduction and leads to the development of NAFLD. Jwa Kum Whan (JKW), a herbal formula in Traditional Korean Medicine, consists of two medicinal herbs that possess notable effects against hyperglycemia and IR. In this study, we sought to determine the pharmacological effects of JKW, and the mechanisms responsible, on hepatic steatosis in free fatty acids (FFAs)-stimulated HepG2 cells and in high-fat diet (HFD)-fed obese mice. Treatment with JKW significantly decreased intracellular lipid accumulation in vitro. Furthermore, JKW significantly triggered the phosphorylation of insulin receptor substrate-1 (IRS-1) and phosphoinositide 3-kinase (PI3K) and modulated glucose and lipid metabolism via an AMP-activated protein kinase (AMPK) signaling pathway. Analysis of serum parameters in HFD-fed mice showed that JKW improved glucose levels and insulin resistance index (HOMA-IR). In addition, JKW successfully reduced hepatic triglyceride (TG) and cholesterol accumulation. Our results suggest that JKW alleviates NAFLD by modulating the insulin signaling pathway and glucose metabolism. These findings provide a scientific rationale for the potential use of JKW for the treatment and prevention of NAFLD.

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Section: Discussionmentioning

confidence: 99%

Jwa Kum Whan Attenuates Nonalcoholic Fatty Liver Disease by Modulating Glucose Metabolism and the Insulin Signaling Pathway

Lim

Kim

Lee

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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“…Benth has traditionally been used in Oriental medicine to treat headaches, gastrointestinal disorders, and amenorrhea for thousands of years (16,17). It has been reported that the extracts of E. rutaecarpa and its alkaloids exhibit anti-obesity, anti-dementia, antiinflammatory, and anti-oxidant effects (18,19). More recently, anti-cancer activities of E. rutaecarpa have been suggested.…”

Section: Discussionmentioning

confidence: 99%

Induction of apoptosis by ethanol extract of <i>Evodia rutaecarpa</i> in HeLa human cervical cancer cells <i>via</i> activation of AMP-activated protein kinase

Park

et al. 2016

BST

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“…E. rutaecarpa is commonly used as an analgesic, antiemetic, anti-inflammatory and astringent drug in TCMs (Tang and Eisenbrand, 1992). The total alkaloids obtained from the fruits of E. rutaecarpa was found and the total antioxidant capacity and inhibitory lipid peroxidation are superior to synthetic antioxidant 2, 6-di-ter-butyl-4-methylphenol (BHT), but scavenging activity on DPPH radical is lower than that of BHT at the same condition (Tan et al, 2011). Wang et al (2006) examined 25 TCMs that might be useful for antioxidant agents and pointed out that L. heterophyllus can effectively inhibit formation of •OH in a concentrationdependent manner.…”

Section: Samplesmentioning

confidence: 99%

Effect of extracts of traditional Chinese medicines on anti-tyrosinase and antioxidant activities

Hsieh¹,

Chang²,

Liu³

2015

J. Med. Plants Res.

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Fifty important cosmetic skin-whiting traditional Chinese medicines (TCMs) were investigated for their anti-tyrosinase and antioxidant (or DPPH-free-radical-scavenging) activities. The water and 70% ethanol extracts (WEs and 0.7EtEs, respectively) of TCMs were tested for tyrosinase inhibitory activities and DPPH-free-radical-scavenging activities. The 10 mg/ml WEs of 6 TCMs, Angelica dahurica, Anredera cordifilia Moq., Cinnamomum aromaticum, Glycyrrhiza glabra, Melia toosendan, and Prunus davidiana, presented over 50% inhibitory effect (referred to as the positive control of 0.5 mg/ml vitamin C) in tyrosinase activity, while Prunus davidiana showed the best anti-tyrosinase activity (94.0%). Only 3 TCMs of 0.7EtEs, Cinnamomum aromaticum, Quisqualis indica, Areca catechu, exhibited over 50% antityrosinase activity. Among the TCMs screened, the 10mg/ml 0.7EtEs of Evodis rutaecarpa, Leonurus heterophyllus, Nardostachys chinensis, and Quisqualis indica, had strong DPPH-free-radicalscavenging effects or antioxidant activities (96.0, 90.5, 92.6 and 80.6%, respectively), while all the WEs of TCMs, except Uncaria sessilifructus Roxb, showed low antioxidant activities (65.6%). The antityrosinase and antioxidant activities of these two TCM extracts may be due to direct linkage to the contents of their active compounds.

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Studies on the Antioxidant Activities of Total Alkaloids from the Fruits of <i>Evodia rutaecarpa</i> <i>(Juss.)</i> Benth

Cited by 7 publications

References 6 publications

Jwa Kum Whan Attenuates Nonalcoholic Fatty Liver Disease by Modulating Glucose Metabolism and the Insulin Signaling Pathway

Jwa Kum Whan Attenuates Nonalcoholic Fatty Liver Disease by Modulating Glucose Metabolism and the Insulin Signaling Pathway

Induction of apoptosis by ethanol extract of <i>Evodia rutaecarpa</i> in HeLa human cervical cancer cells <i>via</i> activation of AMP-activated protein kinase

Effect of extracts of traditional Chinese medicines on anti-tyrosinase and antioxidant activities

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