Studies on the antimicrobial substances of sponges II. Structure and synthesis of a bromine-containing antibacterial, compound from a marine sponge

Sharma, Gurdial M.; Burkholder, Paul R.

doi:10.1016/s0040-4039(01)89710-0

Cited by 81 publications

(43 citation statements)

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“…The Mediterranean sponge Aplysina aerophoba contains brominated metabolites with strong antimicrobial activity [94], thus in 2003 Pabel et al reasoned that as symbiotic bacteria residing in A. aerophoba must be resistant to these bioactive metabolites, they may be capable of producing similar antimicrobial compounds themselves. They discovered 5 Bacillus isolates with pronounced antifungal and antimicrobial activities.…”

Section: Yondelis ® Smenamides and Smenothiazoles: Compounds With mentioning

confidence: 99%

Symbiotic Microbes from Marine Invertebrates: Driving a New Era of Natural Product Drug Discovery

et al. 2017

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Abstract:Invertebrates account for more than 89% of all extant organisms in the marine environment, represented by over 174,600 species (recorded to date). Such diversity is mirrored in (or more likely increased by) the microbial symbionts associated with this group and in the marine natural products (or MNPs) that they produce. Since the early 1950s over 20,000 MNPs have been discovered, including compounds produced by symbiotic bacteria, and the chemical diversity of compounds produced from marine sources has led to them being referred to as "blue gold" in the search for new drugs. For example, 80% of novel antibiotics stemming from the marine environment have come from Actinomycetes, many of which can be found associated with marine sponges, and compounds with anti-tumorigenic and anti-diabetic potential have also been isolated from marine symbionts. In fact, it has been estimated that marine sources formed the basis of over 50% of FDA-approved drugs between 1981 and2002. In this review, we explore the diversity of marine microbial symbionts by examining their use as the producers of novel pharmaceutical actives, together with a discussion of the opportunities and constraints offered by "blue gold" drug discovery.

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Section: Yondelis ® Smenamides and Smenothiazoles: Compounds With mentioning

confidence: 99%

Symbiotic Microbes from Marine Invertebrates: Driving a New Era of Natural Product Drug Discovery

et al. 2017

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“…Sponges, in particular, are responsible for a large number of these compounds, which exhibit a wide range of activities including antitumor (Baslow and Turlapaty, 1969), antiviral (Carter and Rinehart, 1978), antibacterial (Sharma and Burkholder, 1967), and antifungal activity (Phillipson and Rinehart, 1983). The compounds also show broad chemical diversity and are among others comprised of unusual nucleosides (Quinn et al, 1980), terpenes (Cimino et al, 1971), peptides (Stonard and Andersen, 1980), alkaloids (Braekman et al, 1982), fatty acids (Morales and Litchfield, 1976), and unnatural amino acid (which are frequently halogenated) (Crews et al, 1986;Inman and Crews, 1989).…”

Section: Introductionmentioning

confidence: 99%

Screening for antibacterial and antifungal activities in marine benthic invertebrates from northern Norway

Tadesse

Gulliksen

Strøm

et al. 2008

Journal of Invertebrate Pathology

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16 17Benthic marine invertebrates collected from sub-Arctic regions of northern Norway, 18 were found to be a promising source of novel bioactive compounds against human and fish 19 pathogenic bacteria and fungi. Lyophilized material from seven species of ascidians, six 20 sponges and one soft alcyonid coral were extracted with 60% acidified acetonitrile (ACN). 21After separation into an ACN-rich phase (ACN extract) and an aqueous phase, and 22 subsequent solid phase extraction of the aqueous phase, fractions differing in polarity were 23 obtained and screened for antibacterial and antifungal activities, along with the more 24 lipophilic ACN-extracts. Antimicrobial activity was determined against two Gram-negative, 25 two Gram-positive bacteria, and two strains of fungi. Notably, all the invertebrate species in 26 * Manuscript 2 the study showed activity against all four strains of bacteria and the two strains of fungi. In 1 general, the aqueous fractions displayed highest antimicrobial activity, and the most potent 2 extracts were obtained from the colonial ascidian Synoicum pulmonaria which displayed 3 activity against bacteria and fungi at a concentration of 0.02 mg/ml; the lowest concentration 4 tested. 5 6

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“…There were no reports provided for these secondary metabolites again until 1967, when Sharma and Burkholder isolated 2,6-dibromo-4-acetamide-4-hydroxycyclohexadienone (1) and the dimethoxyketal 2 from two marine sponges Verongia fistularis and V. cauliformis (2)(3)(4). Since then, driven by the diverse bioactivities, more and more bromotyrosine-derived marine natural products have been reported.…”

Section: Introductionmentioning

confidence: 99%

The Marine Bromotyrosine Derivatives

Peng¹,

Jing²,

Hamann³

2005

The Alkaloids: Chemistry and Biology

101

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Studies on the antimicrobial substances of sponges II. Structure and synthesis of a bromine-containing antibacterial, compound from a marine sponge

Cited by 81 publications

References 1 publication

Symbiotic Microbes from Marine Invertebrates: Driving a New Era of Natural Product Drug Discovery

Symbiotic Microbes from Marine Invertebrates: Driving a New Era of Natural Product Drug Discovery

Screening for antibacterial and antifungal activities in marine benthic invertebrates from northern Norway

The Marine Bromotyrosine Derivatives

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