Studies on the antigenicity of bone. II. Donor-specific anti-HLA antibodies in human recipients of freeze-dried allografts.

Friedlaender, Gary E.; Dm, Strong; Sell, Kenneth W.

doi:10.2106/00004623-198466010-00014

Cited by 98 publications

(26 citation statements)

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“…Comparing patient outcomes, those who were antibody positive had less favorable outcomes compared to those who were antibody negative [21,68,76]. It is generally believed the antibodies form in response to the bony portion of the graft and, more specifically, the vascular and marrow elements present within the subchondral bone.…”

Section: Fresh Osteochondral Allograftsmentioning

confidence: 99%

Clinical Cartilage Restoration: Evolution and Overview

Farr

Cole

Dhawan

et al. 2011

Clinical Orthopaedics &Amp; Related Research

214

166

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Background Clinical cartilage restoration is evolving, with established and emerging technologies. Randomized, prospective studies with adequate power comparing the myriad of surgical techniques used to treat chondral injuries are still lacking and it remains a challenge for the surgeon treating patients to make evidence-based decisions. Questions/purposes We reviewed the history of the major cartilage repair/restorative procedures, indications for currently available repair/restorative procedures, and postoperative management. Methods We performed searches using MEDLINE and cartilage-specific key words to identify all Englishlanguage literature. Articles were selected based on their contributions to our current understanding of the basic science and clinical treatment of articular cartilage lesions or historical importance. We then selected 77 articles, two of which are articles of historical importance. Results Current cartilage restorative techniques include débridement, microfracture, osteochondral fragment repair, osteochondral allograft, osteochondral autograft, and autologous chondrocyte transplantation. Pending techniques include two-staged cell-based therapies integrated into a variety of scaffolds, single-stage cell-based therapy, and augmentation of marrow stimulation, each with suggested indications including lesion size, location, and activity demands of the patient. The literature demonstrates variable improvements in pain and function contingent upon multiple variables including indications and application. Conclusions For the patient with symptomatic chondral injury, numerous techniques are available to the surgeon to relieve pain and improve function. Until rigorous clinical trials (prospective, adequately powered, randomized control) are available, treatment decisions should be guided by expert extrapolation of the available literature based in historically sound principles.

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Section: Fresh Osteochondral Allograftsmentioning

confidence: 99%

Clinical Cartilage Restoration: Evolution and Overview

Farr

Cole

Dhawan

et al. 2011

Clinical Orthopaedics &Amp; Related Research

214

166

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“…In others, there was sensitization against some of the samples (Friedlaender et at. 1976(Friedlaender et at. , 1978(Friedlaender et at.…”

Section: Discussionmentioning

confidence: 99%

Lipid extraction decreases the specific immunologic response to bone allografts in rabbits

Thoren

Aspenberg

Thorngren

1993

Acta Orthopaedica Scandinavica

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“…Only g.e. Friedlaender et al have reported an allo-sensitization by the transplantation of freeze-dried musculoskeletal allografts in orthopedic application [29]. However, the latter did not result in any clinical effects.…”

Section: Safety Aspects Of Allogeneic Bone Grafting Materialsmentioning

confidence: 99%

Allogeneic Bone Grafting Materials – Update of the Current Scientific Status

Schnettler

Franke²,

Rimashevskiy

et al. 2017

Traumatology and Orthopedics of Russia

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Worldwide population aging and associated with it epidemics of osteoporosis, widespread of bone and joint reconstructive surgery and first of all joint replacement lead to explosive growth of interest in bone grafting.Although autografts are still the golden standard in bone regeneration, allogeneic bone substitutes have reached a state that allows for their application with satisfying clinical results. However, it has repeatedly been supposed that the different allogeneic materials underwent different purification processes, which modifies bone regeneration properties of these materials and also for different safety conditions. In the present publication, the treatment of the precursor tissue, the safety conditions, and the regenerative possibilities of C+TBA bone blocks based in preclinical and clinical data are described. Thus, it is described how the risks of infections and also immunological reactions becomes completely eliminated, while the special purification process allows for preservation of the native structure of the bone block. Both the in vitro studies and the clinical trials including histological follow-ups showed the optimal regeneration properties of these bone blocks. It has been shown that the allogeneic bone grafts have been integrated without causing inflammatory anomalies at the implantation site. Altogether, the allogeneic bone substitute material serves as an excellent basis for the formation of new bone. Finally, the combination of the allogeneic C+TBA bone blocks with different antibiotics is described. Interestingly, it is possible to combine the allogeneic bone substitute ether with antibiotics in the sense of prophylaxis and/or with bone marrow aspirate in order to accelerate bone remodeling.

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Studies on the antigenicity of bone. II. Donor-specific anti-HLA antibodies in human recipients of freeze-dried allografts.

Cited by 98 publications

References 0 publications

Clinical Cartilage Restoration: Evolution and Overview

Clinical Cartilage Restoration: Evolution and Overview

Lipid extraction decreases the specific immunologic response to bone allografts in rabbits

Allogeneic Bone Grafting Materials – Update of the Current Scientific Status

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