Lipid extraction decreases the specific immunologic response to bone allografts in rabbits

Thoren, K.; Aspenberg, Per; Thorngren, Karl–Göran

doi:10.3109/17453679308994526

Cited by 35 publications

(16 citation statements)

References 11 publications

(3 reference statements)

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“…Similarly, defatting also reduced the immunogenic properties of the graft and hence the immunological response. 48 This paper highlights the numerous variables that influence the outcome of impaction bone grafting, including the effects of irradiated bone graft, implant and patient variables. The degree of bone loss and the level of irradiation of the allograft appeared to be the two most important variables associated with a poor outcome.…”

Section: Discussionmentioning

confidence: 99%

Subsidence of the stem after impaction bone grafting for revision hip replacement using irradiated bone

Hassaballa

Mehendale

Poniatowski

et al. 2009

The Journal of Bone and Joint Surgery. British volume

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Loss of bone stock is a major problem in revision surgery of the hip. Impaction bone grafting of the femur is frequently used when dealing with deficient bone stock. In this retrospective study a consecutive series of 68 patients (69 hips) who had revision of a hip replacement with femoral impaction grafting were reviewed. Irradiated bone allograft was used in all hips. Radiological measurement of subsidence of the stem, incorporation of the graft and remodelling was carried out and showed incorporation of the graft in 26 of 69 hips (38%). However, there was no evidence of trabecular remodelling. Moderate subsidence of 5 mm to 10 mm occurred in ten hips (14.5%), and massive subsidence of > 10 mm in five (7.2%). The results of this study are less favourable than those of others describing studies of revision of the femoral stem using impaction bone grafting. The absence of the characteristic changes of graft remodelling noted in other series raises the question as to whether irradiated bone graft may be a significant factor influencing the post-operative outcome.

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Section: Discussionmentioning

confidence: 99%

Subsidence of the stem after impaction bone grafting for revision hip replacement using irradiated bone

Hassaballa

Mehendale

Poniatowski

et al. 2009

The Journal of Bone and Joint Surgery. British volume

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“…46 Similar results have been found with solvent defatted allograft in non-impacted bone chamber models in rabbits. 47,48 It is not clear whether this increased ingrowth is secondary to the more porous nature of rinsed bone or whether there is some form of biological inhibition from the marrow. Rinsing the graft also removes most of the marrow, allowing a reduction in the immunological load to the patient.…”

Section: Rinsing Of Graftmentioning

confidence: 99%

Impaction allografting in revision total hip replacement

Board

Rooney²,

Kearney³

et al. 2006

The Journal of Bone and Joint Surgery. British volume

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“…The authors hypothesised that rinsing removes immunogenic factors present in the allograft leading to the improved incorporation. Conversely, it has been suggested that rinsing removes beneficial factors from the autograft and leads to poorer incorporation (Aspenberg and Thoren 1990;Thoren et al 1993Van der Donk et al 2003).…”

Section: Particle Gradingmentioning

confidence: 99%

Impaction bone grafting in revision hip surgery: past, present and future

McNamara

2010

Cell Tissue Bank

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Joint replacement surgery can have excellent clinical results. However, as the number of patients undergoing surgery increases, the number of failed joint replacements is set to rise. One of the greatest challenges for the revision surgeon is the restoration of bone stock. This article focuses upon revision hip surgery, with particular reference to the scope of the problem; historical and current solutions to bone loss in the femur and acetabulum; the clinical results following revision surgery; and the basic science behind impaction bone grafting, before ending with possible future directions for improving the restoration of bone stock.

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Lipid extraction decreases the specific immunologic response to bone allografts in rabbits

Cited by 35 publications

References 11 publications

Subsidence of the stem after impaction bone grafting for revision hip replacement using irradiated bone

Subsidence of the stem after impaction bone grafting for revision hip replacement using irradiated bone

Impaction allografting in revision total hip replacement

Impaction bone grafting in revision hip surgery: past, present and future

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