Studies on segmented polyetherurethane for biomedical application: Effects of composition and hard-segment content on biocompatibility

Abstract

Segmented polyetherurethane (SPEU) materials based on polytetramethylene oxide (PTMO, Mw 1000 and 2000) with various hard-segment contents were synthesized and their biocompatibilities studied via different tests. The static contact angle data reveal that the higher hard-segment-content SPEU material possesses a lower contact angle, implying that the surface of the higher hard-segment-content SPEU is more hydrophilic than its low hard-segment-content SPEU counterpart. The catalyst- and additive-free PTMO-based SPEU materials in this study possess neither a hemolytic nor a cytotoxic response that could be considered non toxic for biomedical applications. By using L-929 cell lines, a cell-seeding test indicated that the higher hard-segment-content SPEU material possesses quicker cell attachment and proliferation behaviors. In vitro platelet adhesion tests indicated that the lower hard-segment-content SPEU possesses less platelet adhesion than the high hard-segment-content SPEU material. Both ex vivo canine artery-artery (A-A) and arterio-venous (A-V) shunting tests revealed that the extent of platelet adhesion reaction is less for lower hard-segment content SPEU. In addition, the blood compatibility of SPEU material synthesized from PTMO 1000 excels over PTMO 2000 SPEU material by near the same levels as the hard-segment-content SPEU.

Selection of a Polyurethane Membrane for the Manufacture of Ventricles for a Totally Implantable Artificial Heart: Blood Compatibility and Biocompatibility Studies

“…2). To our knowledge, although no studies in the literature report a direct comparison of the cytocompatibility of Tecoflex and Tecothane, some investigators showed that, despite relatively good viability to various types of cells including monocytes, fibroblasts, and endothelial cells, both polyurethane surfaces provide poor cell adhesion proliferation, as reported here (17,18). Currently, no evidence exists to suggest that HMDI is more biocompatible than MDI.…”

Protein‐resistant polyurethane via surface‐initiated atom transfer radical polymerization of oligo(ethylene glycol) methacrylate

“…Based on the nitrogen content (2.9 atom percent) of the unmodified PU surface determined at 90° takeoff angle, the nx value should be about 10. However, the oxygen content was found to be close to that of the polyol moieties (20 atom %) possibly because the polyols are more hydrophobic than the urethanes and tend to dominate the air/polymer interface, especially under the vacuum condition of XPS operation 52, 53…”

The influence of isocyanurate content on the bioperformance of hydrocarbon-based polyurethanes

“…They found that platelet activation was affected by hardsegment composition (urethane/urea proportion) but still observed an increase of platelet and fibrinogen adhesions with increasing hard-segment content. Similarly, Chen et al [57] observed higher platelet adhesion for segmented polyether urethane (SPEU) having the higher hard-segment content. Here, an increase in I-IPDI content did not enhance platelet adhesions or fibrinogen adsorption.…”