Studies on renal arteries origin from the aorta in respect to superior mesenteric artery in Polish population

Sośnik, H; Sośnik, Katarzyna

doi:10.5603/fm.a2019.0065

Cited by 2 publications

(5 citation statements)

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“…The average distance between SMA and renal arteries in children aged 0 to 20 years was 3.3±2.5 mm for the RRA and 4.1±3.7 mm for the LRA. The values reported by Sośnik and Sośnik 15 were nearly 60% lower than ours. The reasons for this discrepancy might be explained by the differences in the diagnostic tools, age of the study population, and geographical factors.…”

Section: Discussioncontrasting

confidence: 77%

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Normal Distance Measurements Between the Origins of the Major Branches of the Abdominal Aorta on Computed Tomography Angiography in Children

Çolak¹

2022

NKTD

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Aim:The aim of the present study was to determine the normal distances between the origins of the major branches of the abdominal aorta, and their distances to the aorta at the diaphragmatic region and iliac bifurcation on multidetector computed tomography (MDCT) angiography in pediatric patients. Materials and Methods:The MDCT angiography scans obtained from 245 children aged between 0 and 18 years (mean age±standard deviation, 8.48±5.14 years) were retrospectively re-evaluated. The distances between the origins of the celiac trunk (CTR), superior mesenteric artery (SMA), right renal artery (RRA), left renal artery (LRA), and inferior mesenteric artery (IMA) were measured. The distance measurements between the aorta at the diaphragmatic region, iliac bifurcation, and the origins of the major branches (CTR, SMA, RRA, LRA, IMA) were performed as well. Results:The distances between the abdominal aorta and its branches were reported to vary in the age groups. All the distance measurements increased significantly with increasing age (p<0.0001). The distances between the aorta at the diaphragmatic region and the origins of the major branches were significantly higher in girls (p<0.05). The origin of the RRA was higher than the LRA in 51.8% of the study population. Conclusion:This study is the first to provide data on the distances between the abdominal aorta and its branches in children. The present results may contribute to enhance the efficacy and safety of the endovascular and surgical procedures in the abdominal region.

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Section: Discussioncontrasting

confidence: 77%

“…Sośnik and Sośnik 15 measured the SMA-RRA and SMA-LRA distances in 324 cadavers aged between 0 and 90 years. The average distance between SMA and renal arteries in children aged 0 to 20 years was 3.3±2.5 mm for the RRA and 4.1±3.7 mm for the LRA.…”

Section: Discussionmentioning

confidence: 99%

Normal Distance Measurements Between the Origins of the Major Branches of the Abdominal Aorta on Computed Tomography Angiography in Children

Çolak¹

2022

NKTD

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“…This was done by qualitative observations of the renal angiograms like those shown in Figures 2 , 3 , 4 . Additionally, the renal takeoff angles observed in these animals tend to branch off superiorly from the aorta, while studies have shown that human renal takeoff angles tend to branch inferiorly (Trani et al, 2009 ; Wozniak, 2000 ) as shown in Figure 7 . Furthermore, measurements of the main renal arteries showed that despite having slightly smaller average diameters (1 mm and 0.5 mm at most in the left and right renal main respectively), the average lengths of the renal main arteries were comparable (LMA/RMA of 32.18 ± 7.46/42.23 ± 7.33 mm in porcine and 34.8 ± 12.5/41.4 ± 15.0 mm in human) (Lauder et al, 2018 ).…”

Section: Discussionmentioning

confidence: 85%

“…Though this approach is meant to simulate human use conditions, porcine anatomy was primarily used for this research. In general, the porcine organs used in these studies had smaller diameters and more superior renal artery takeoff angles when compared to the average human (Lauder et al, 2018 ; Trani et al, 2009 ; Wozniak, 2000 ). Additionally, the results presented here indicate that porcine main renal arteries are less tortuous than humans via qualitative analysis and future studies can be done to quantify these differences.…”

Section: Discussionmentioning

confidence: 95%

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Preclinical research performed on reanimated/perfused swine kidneys: The Visible Kidney™ methodologies

Valenzuela

Schinstock

Kohnle

et al. 2023

Physiological Reports

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Preclinical research remains the essential platform in the development and optimization of medical therapies and advancements in translational medicines. However, specifically to animal research, federal laws, and institutional policies require investigators to apply the principles of the 3R's (replacement, reduction, and refinement). The concept of benchtop models utilizing isolated organs, in which multiple variables can be controlled to recreate human function, has been innovative advancements in preclinical research models that adhere to these principles. More specifically, isolated perfused kidney (IPK) models have been invaluable preclinical tools that have led to numerous advancements over the decades, including understanding renal physiology, pharmacologic therapies, and improvements in renal transplantation. However, pre‐existing IPK models are not without their own limitations, leaving areas for improvement. An isolated perfused kidney apparatus was designed to best recreate human use conditions as a preclinical tool. Porcine renal blocks were chosen over the more commonly used rodent models, due to their greater similarities to human anatomies. Sixteen porcine kidney pairs obtained en bloc were extracted and placed onto an apparatus where aortic flows, pressures, and overall systemic temperatures were controlled. Organ viability was assessed in 10 renal blocks (n = 8 fresh and n = 2 previously frozen specimens) via both urinary flows and compositions at timepoints up to 180 min. Multimodality imaging, which included fluoroscopy, ultrasound, optical coherence tomography (OCT), and video scopes, was also employed to capture internal and external images to determine renal artery orientations and dimensions. Anatomical measurements and viability assessments of porcine renal blocks were successfully achieved in our perfusion model. Renal main artery diameters averaged smaller in our sample size than in human anatomy while also having more superior takeoff angles. Yet, the average lengths of each main segment were comparable to human anatomy: 32.09 ± 7.97 mm and 42.23 ± 7.33 mm in the left and right renal main artery, respectively. Urine production and urine composition of the fresh renal blocks, when compared to the frozen blocks and baseline perfusate, showed kidney viabilities of up to 3 h via excretion and retention of various metabolites. In this paper, we described a protocol for an isolated perfused kidney apparatus using large mammalian renal blocks. We believe this protocol to be an improvement from similar pre‐existing models in better representing human physiologic function while allowing for multimodal imaging. The resulting Visible Kidney™ preclinical model, which has shown viability after isolation and reperfusion, can be a fast and reliable tool for the development of medical devices while also reducing the unnecessary use of animals for research.

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Studies on renal arteries origin from the aorta in respect to superior mesenteric artery in Polish population

Cited by 2 publications

References 0 publications

Normal Distance Measurements Between the Origins of the Major Branches of the Abdominal Aorta on Computed Tomography Angiography in Children

Normal Distance Measurements Between the Origins of the Major Branches of the Abdominal Aorta on Computed Tomography Angiography in Children

Preclinical research performed on reanimated/perfused swine kidneys: The Visible Kidney™ methodologies

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