Studies on promoting activity of Taiwan betel quid ingredients in hamster buccal pouch carcinogenesis

Jin, Ying; Tsai, Sen Tien; Wong, Tung Yiu; Chen, F.-F.; Chen, R.M.-Y.

doi:10.1016/0964-1955(96)00018-8

Cited by 35 publications

(16 citation statements)

References 19 publications

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“…Cells were treated with 50 nM paclitaxel at different time points (8,24, 36 and 48 h), and cell cycle progression was determined by flow cytometry analysis. In Fig.…”

Section: Effects Of Paclitaxel On Cell Cycle Progression In Hnscc Celmentioning

confidence: 99%

Apoptotic mechanism of paclitaxel‐induced cell death in human head and neck tumor cell lines

Hsiao

Leu

Huang

2009

J Oral Pathology Medicine

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“…Cells were treated with 50 nM paclitaxel at different time points (8,24, 36 and 48 h), and cell cycle progression was determined by flow cytometry analysis. In Fig.…”

Section: Effects Of Paclitaxel On Cell Cycle Progression In Hnscc Celmentioning

confidence: 99%

Apoptotic mechanism of paclitaxel‐induced cell death in human head and neck tumor cell lines

Hsiao

Leu

Huang

2009

J Oral Pathology Medicine

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“…Leaves are also considered useful in treating bronchitis, difficulty in breathing and cough (Nadkarni, 1976). There are some conflicting reports of the carcinogenic potential of chewing the betel quid (Chen et al, 1984;Stich et al, 1986;Lu et al, 1996;Lee-Chen et al, 1996;Jin et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

The presence of Cholinomimetic and calcium channel antagonist constituents in Piper betle Linn.

et al. 2000

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“…Moreover, more than 2,400 new cases of oral cancer arising from OSF are diagnosed every year in Taiwan due to the prevalent use of betel quid (8). In another study by Jian, three cases of oral cancer were found in 147 cases of OSF in Hunan (9).…”

Section: Introductionmentioning

confidence: 99%

Discovery of Novel Biomarkers in Oral Submucous Fibrosis by Microarray Analysis

Jian

et al. 2008

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Oral submucous fibrosis (OSF) is a high-risk precancerous condition of the oral cavity. Areca nut chewing is its key etiologic factor, but the full pathogenesis is still obscure. In this study, microarray analysis was used to characterize the mRNA changes of 14,500 genes in four OSF and four normal buccal mucosa samples to identify novel biomarkers of OSF. Five candidate genes with the most differential changes were chosen for validation. The correlation between clinicopathologic variables of 66 OSF patients and the expression of each gene was assessed by immunohistochemistry. The microarray analysis showed that 661 genes were up-regulated (fold value >2) and 129 genes were downregulated (fold value <0.5) in OSF (q < 0.01). The top three up-regulated genes [Loricrin, Cartilage oligomeric matrix protein (COMP), Cys-X-Cys ligand 9 (CXCL9)] with the largest fold changes and the top two downregulated genes [keratin 19 (KRT19), cytochrome P450 3A5 (CYP 3A5)] with the most significantly differential changes in OSF were chosen as candidate biomarkers. In immunohistochemical results, the expression of Loricrin and COMP showed statistically significant association with histologic grade of OSF (P = 0.03 and 0.006, respectively). COMP was found to be overexpressed frequently in patients with the habit of areca nut chewing for more than 4 years (P = 0.002). CYP 3A5 was revealed an inverse correlation with histologic grade (P = 0.04). This pilot study showed that five novel genes might play important roles in the pathogenesis of OSF and may be clinically useful for early detection of OSF. (Cancer Epidemiol Biomarkers Prev 2008;17(9):2249 -59)

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Studies on promoting activity of Taiwan betel quid ingredients in hamster buccal pouch carcinogenesis

Cited by 35 publications

References 19 publications

Apoptotic mechanism of paclitaxel‐induced cell death in human head and neck tumor cell lines

Apoptotic mechanism of paclitaxel‐induced cell death in human head and neck tumor cell lines

The presence of Cholinomimetic and calcium channel antagonist constituents in Piper betle Linn.

Discovery of Novel Biomarkers in Oral Submucous Fibrosis by Microarray Analysis

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