Studies on Production of Nucleic Acid and its Related Compounds by Microorganisms

Studies on the “Salvage” Synthesis of Ribonucleosides and Their 5′-Phosphates by Microorganisms

“…----pH tively produced, namely, the yield of inosine from hypoxanthine reached more than 60% and the conversion proceeded stoichiometrically, and any other oxidized by-products of hypoxanthine were not detected. 4. Substrate specificity for the formation of ribonueIeosides by F. suaveolens…”

Studies on the Production of Nucleosides by Microorganisms

“…Several reports have been presented concerning the conversion of nucleic acid bases or their analogues to corresponding ribonucleosides by cell-free extracts or whole cells of microorganisms (1)(2)(3)(4)(5)(6)(7)(8)(9)(10). These observations may be classified into the following two groups according to the mechanisms of ribonucleosides formation : (1) the presence of ribose donors such as ribonucleosides or ribonucleotides are necessary for the reactions (1)(2)(3)(4)(5), and (2) ribonucleosides are well formed when suitable carbon sources such as glucose, glycerol, etc., are present instead of ribonucleosides or ribonucleotides (6)(7)(8)(9)(10).…”

“…These observations may be classified into the following two groups according to the mechanisms of ribonucleosides formation : (1) the presence of ribose donors such as ribonucleosides or ribonucleotides are necessary for the reactions (1)(2)(3)(4)(5), and (2) ribonucleosides are well formed when suitable carbon sources such as glucose, glycerol, etc., are present instead of ribonucleosides or ribonucleotides (6)(7)(8)(9)(10). In the former cases, ribonucleosides are formed by a transfer of the ribosyl group from donors to bases, and in many cases coupled nucleoside phosphorylase reactions with ribose-1-phosphate as the intermediate have been proposed as a mechanism of the reaction (1,2,5).…”

“…In the former cases, ribonucleosides are formed by a transfer of the ribosyl group from donors to bases, and in many cases coupled nucleoside phosphorylase reactions with ribose-1-phosphate as the intermediate have been proposed as a mechanism of the reaction (1,2,5). Of the latter cases some mechanisms have been proposed, but the details have not yet been clarified (9).…”

Formation of Ribonucleosides From Bases by Nucleoside Producing Mutants of Bagillus Subtilis

“…Several reports have been presented concerning the microbial conversion of nucleic acid bases to their ribonucleosides (1)(2)(3)(4)(5)(6), and it has been found that, in many cases, the presence of suitable ribose donors such as ribonucleosides or ribonucleotides is necessary for these reactions (1-4), but not in fewer cases (5,6).…”