Studies on polypeptides XXXIV. Replacement of histidine‐2 in Luliberin (LH‐RH) by L‐homohistidine

Abstract

Abstract.[Homohistidine']LH-RH has been synthesized by the solid phase method. NMR and CD spectra at two pH values have been measured. The remarkably low in uitro potency of the component, relative to LH-RH, is discussed in terms of conformational differences.