Studies on Poliovirus Inhibitors in Sera of Domestic Animals

Urasawa, Shozo; Urasawa, Tomoko; Akahonai, Yoshikazu; Kanamitsu, Masatsugu

doi:10.7883/yoken1952.22.87

Cited by 8 publications

(1 citation statement)

References 5 publications

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“…Although many workers were of the opinion that poliovirus-reactive substances are mostly immunoglobulin M (IgM) of the serum (2-5), we demonstrated by radioimmunoelectrophoretic and other methods that they are heterogeneous with respect to the immunoglobulin class: the active substances in equine sera were identified as one of the three immunoglobulins, IgM, slowly migrating IgG and IgG (T) previously referred to as IgA (T) (6), while those in bovine sera were found to be either IgM or IgG globulin (7,8). From these results, we henceforth use the term poliovirus-reactive immunoglobulins (PRIgs) for these active substances.…”

Section: Introductionmentioning

confidence: 89%

Comparison of Naturally Occurring Poliovirus-Reactive Immunoglobulins in Bovine and Equine Sera

Urasawa¹,

Urasawa²,

Ishizawa³

et al. 1987

JJMSB

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Section: Introductionmentioning

confidence: 89%

Comparison of Naturally Occurring Poliovirus-Reactive Immunoglobulins in Bovine and Equine Sera

Urasawa¹,

Urasawa²,

Ishizawa³

et al. 1987

JJMSB

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Inhibitors against rabies virus present in normal rabbit sera

Sekine

Yoshino

1974

Archiv f Virusforschung

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Radioimmunoelectrophoretic identification of poliovirus inhibitors and their characteristic mode of action

Urasawa

Kanamitsu

1971

Archiv f Virusforschung

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SummaryPoliovirus inhibitors present in normal equine and bovine sera were studied by means of radioimmunoeleetrophoresis and column chromatography. The inhibitors in individual equine sera were identified as either one of the three immunoglobulins, yM, yA(T) and yG, or mixtures of them, while those in bovine sera were found to be either one of yM and yG globulins, or the mixture of the two.The inhibitors belonging to different classes of immnnoglobulin differed in their mode of action against the virus, yM inhibitors were characterized by distinct activities in the kinetic neutralization and the plaque reduction tests. In contrast, yA(T) inhibitors were highly active in the plaque-reduction and the precipitationin-agar-gel tests, although they were inactive in the kinetics of neutralization. There were two types of yG inhibitors. One did not neutralize the virus in the kinetic test, despite its distinct virus-precipitating activity. The other could neutralize but not precipitate the virus in vitro.Avidity of the inhibitors as revealed by dissociation of virus-inhibitor complexes at acidic pH's also differed among the immunoglobulin classes of the inhibitors. The complex formed with the NaIO4-treated yA(T) inhibitor was most stable and was not dissociated even at pH as low as 2.0.

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Studies on Poliovirus Inhibitors in Sera of Domestic Animals

Cited by 8 publications

References 5 publications

Comparison of Naturally Occurring Poliovirus-Reactive Immunoglobulins in Bovine and Equine Sera

Comparison of Naturally Occurring Poliovirus-Reactive Immunoglobulins in Bovine and Equine Sera

Inhibitors against rabies virus present in normal rabbit sera

Radioimmunoelectrophoretic identification of poliovirus inhibitors and their characteristic mode of action

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