Studies on performance with aspirin and paracetamol and with the centrally acting analgesics meptazinol and pentazocine

Bradley, C. M.; Nicholson, A. N.

doi:10.1007/bf00542185

Cited by 27 publications

(27 citation statements)

References 21 publications

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“…In a previous study in which 1,000 mg ACET served as a negative control condition, the drug did not impair performance on the LRT [21]. As well, acetaminophen produced no subjective or any other psychomotor effects, consistent with three other studies in the literature that tested doses ranging from 500 to 2,000 mg [22–24]. While it is possible that acetaminophen may have produced impairment on one psychomotor test in the present study, the fact that no other effects were noted and that other studies have found no psychotropic effects of the drug suggest that the finding is anomalous and, perhaps, a Type I error, rather than representative of a “real” effect.…”

Section: Discussionsupporting

confidence: 89%

Subjective, Psychomotor, and Physiological Effects Profile of Hydrocodone/Acetaminophen and Oxycodone/Acetaminophen Combination Products: Table 1

Zacny¹,

Gutierrez²

2008

Pain Med

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The results of this study, albeit in pain-free individuals, may inform physicians who prescribe, and pharmacists who dispense, two widely prescribed opioid/acetaminophen combination products on how patients might be feeling from the drugs. Patients prescribed either of the two opioid/acetaminophen combination products may experience a number of subjective effects, including effects that would contraindicate certain activities, and they should be cautioned accordingly. However, this study documented rather large differences in magnitude of subjective effects between 10 mg oxycodone/650 mg acetaminophen and placebo, and physicians and pharmacists, and ultimately patients, should be aware of these differences.

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Section: Discussionsupporting

confidence: 89%

Subjective, Psychomotor, and Physiological Effects Profile of Hydrocodone/Acetaminophen and Oxycodone/Acetaminophen Combination Products: Table 1

Zacny¹,

Gutierrez²

2008

Pain Med

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“…The Zacny and Gutierrez (2009) study was included in the retrospective analysis even though oxycodone was combined with acetaminophen. Acetaminophen by itself did not have any effects, and this lack of psychoactive effects has been documented in several other studies (Bradley and Nicholson, 1987; Eade and Lasagna, 1967; Pickworth et al, 1991; Zacny et al, 2005). …”

Section: Methodssupporting

confidence: 74%

A possible link between sensation-seeking status and positive subjective effects of oxycodone in healthy volunteers

Zacny

2010

Pharmacology Biochemistry and Behavior

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Sensation seeking is a personality trait that is linked to use and abuse of drugs. Laboratory studies have established that high sensation seekers, as measured by different instruments, are more likely to report abuse liability-related subjective effects from drugs such as nicotine, alcohol, and d-amphetamine than low sensation seekers. One class of drugs that has not been studied to date in this fashion is opioids. Accordingly, a retrospective analysis encompassing five studies that examined oxycodone effects, including its abuse liability-related effects, was conducted in subjects categorized as high or low sensation seekers. In addition, because there appear to be sex differences in how males and females respond to opioids, this factor was taken into account in the analysis. Seventy one subjects who scored on the lower end (15 and 19 low sensation seeking males and females, respectively) or the higher end (23 and 14 high sensation seeking males and females) of the Disinhibition subscale of the Sensation Seeking Scale-Form V were studied for their responses to 0, 10, and 20 mg of oral oxycodone. Ratings of “pleasant bodily sensations” were significantly higher after oxycodone administration than placebo only in male and female high sensation seekers. Ratings of “take again,” “drug liking,” “carefree,” and “elated (very happy)” also tended to differentiate high from low sensation seekers although Group × Dose interactions were only marginally significant with the latter three ratings. Male and female low sensation seekers and female high sensation seekers reported dysphoric effects (e.g., ratings of nauseated) particularly after administration of the 20-mg oxycodone dose. The results of this analysis provide suggestive evidence that high sensation seekers are more likely to experience greater positive subjective effects from oxycodone than low sensation seekers, but likelihood of experiencing negative effects is more complex (involving both sensation seeking status and sex).

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“…We found a significantly decreasing effect of ASA on reaction time about 35 min after intake. A similar effect has been shown by Bradley and Nicholson (1986) in a psychophysiological experiment for complex reaction time. Bromm et al (1991) did not see any effect of ASA on reaction time, but they only measured the simple and not, as in our study, the choice reaction time.…”

Section: Discussionsupporting

confidence: 67%

“…Bromm et al (1991) did not see any significant effects of ASA on spontaneous EEG, auditory evoked potentials, and reaction time in humans. However, Bradley and Nicholson (1986) observed a decrease of complex reaction time by ASA. In a study on contingent negative variation (CNV) in healthy individuals, an ASA-induced decrease in the early wave and an increase in the late wave amplitudes has been shown (Vein et al 1995).…”

Section: Introductionmentioning

confidence: 75%

The influence of acetylsalicylic acid on cognitive processing: an event-related potentials study

et al. 1998

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The central effects of acetylsalicylic acid (ASA) are discussed controversially. In animal models, it has been shown that ASA can interact with the central serotonergic and catecholaminergic neuronal system. However, the relevance of this interaction for humans is still unknown. We performed a study on the influence of ASA on central cognitive processing. In 25 healthy subjects (age 21-56 years), visually evoked event-related potentials (ERP) and reaction time under IV ASA medication were recorded. ERP were evoked by an oddball paradigm. As compared to placebo, ASA decreased the latency of the P3 component significantly in a time interval of 20-40 min after administration. The latency of the N2 component was significantly decreased about 25 min after administration; the latency of the exogenous P2 component was not influenced by ASA. The mean choice reaction time was significantly decreased by ASA 35 min after administration. At this time point, there was a significant correlation between decrease in reaction time and increase in ASA plasma level. The data show that IV administration of ASA has an accelerating effect on the endogenous components of visual ERP and on reaction time. This finding suggests that ASA can influence central cognitive processing, possibly by ASA induced changes of neurotransmitters. Since serotonin can be released by ASA and serotonin release leads to a decrease of ERP latencies. we assume that ASA most likely influences cognitive processing via the central serotonergic transmitter system.

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Studies on performance with aspirin and paracetamol and with the centrally acting analgesics meptazinol and pentazocine

Cited by 27 publications

References 21 publications

Subjective, Psychomotor, and Physiological Effects Profile of Hydrocodone/Acetaminophen and Oxycodone/Acetaminophen Combination Products: Table 1

Subjective, Psychomotor, and Physiological Effects Profile of Hydrocodone/Acetaminophen and Oxycodone/Acetaminophen Combination Products: Table 1

A possible link between sensation-seeking status and positive subjective effects of oxycodone in healthy volunteers

The influence of acetylsalicylic acid on cognitive processing: an event-related potentials study

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