Studies on Palauan Medicinal Herbs. II. Activation of Mouse Macrophages RAW 264.7 by Ongael, Leaves of Phaleria cumingii (MEISN.) F. VILL. and Its Acylglucosylsterols

Mangiferin induces apoptosis by suppressing Bcl-xL and XIAP expressions and nuclear entry of NF-κB in HL-60 cells

“…It is widely distributed in plants such as those of the Thymeraceae families (e.g., Phaleria cumingii, Ongael), especially in the leaves (Matsuda et al, 2005a). Recently, it was reported that mangiferin induces apoptosis (Matsuda et al, 2005b); however, the mechanism of this process was not elucidated.…”

Traditional preparation of Phaleria nisidai, a Palauan tea, reduces exposure to toxic daphnane-type diterpene esters while maintaining immunomodulatory activity

“…Mangiferin, the most abundant compound in aqueous extracts (Kitalong et al, 2012b), did not show immune stimulation in work done by Matsuda in in vivo and in vitro cytokine assays (Matsuda et al, 2004) and in our preliminary studies.…”

“…Mangiferin (Matsuda et al, 2004), the benzophenone iriflophenone-2-O-Į-rhamnoside and the flavonoid genkwanin-5-O-ȕ-D-primeveroside (Kitalong et al, 2012), tetracosonol and a mixture of acylglucosylsterols (Matsuda et al, 2005) are the only compounds other than daphnanes that have been identified from this plant. Mangiferin, the most abundant compound in aqueous extracts (Kitalong et al, 2012b), did not show immune stimulation in work done by Matsuda in in vivo and in vitro cytokine assays (Matsuda et al, 2004) and in our preliminary studies.…”

“…Previous pharmacological studies of Phaleria nisidai have demonstrated immunostimulatory activity in hydroalcoholic leaf extracts in vivo and in vitro (Matsuda et al, 2005(Matsuda et al, , 2004. We have previously used the production of IFNȖ by peripheral blood mononuclear cells (PBMCs) to guide fractionation of a methanol extract of P. nisidai and found that daphnane-type diterpene orthoesters contribute to the immunostimulatory activity of this plant (Kulakowski et al, 2014), which was the first report of diterpene esters from the Phaleria genus.…”

The beneficial effects of tetracosanol on insulin-resistance by insulin receptor kinase sensibilisation

“…extract (Matsuda et al, 2005), vegetable oils (perilla seed oil, grape seed oil, and rice bran oil) (Jung, Lee, Yoon, & Jung, 2011), sugar cane epicuticular waxes (Arruzazabala et al, 2000), and wheat germ oil (Irmak & Dunford, 2005). Ongael extract has been found to enhance the in vitro phagocytic activity of mouse macrophage RAW 264.7 cells (Matsuda et al, 2005), and wheat germ oil has been reported to improve human physical fitness, which is attributed to its high PC content and specifically for its high tetracosanol content (Irmak & Dunford, 2005). Tetracosanol from pomace of olive oil products modulates the release of proinflammatory mediators (Fernandez-Arche et al, 2009).…”