Studies on Ointments

The local, articular, and systemic absorption of oral and topical salicylates was studied in dogs and humans using radioisotope techniques. Topical triethanolamine 14C-salicylate was found capable of percutaneous absorption into the knee joint and surrounding tissues. In dogs, topical salicylate application resulted in higher salicylate concentrations than oral aspirin in a number of tissues, despite lower blood levels. In patients with rheumatoid arthritis, intraarticular 14C-salicylate levels after triethanolamine 14C-salicylate cream were 60 per cent of those obtained with oral aspirin. Four of six patients reported equal improvement in local discomfort after oral and topical salicylates. A potential role for topical salicylate cream in the treatment of localized rheumatic disorders is suggested.

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Studies on Ointments

Cited by 11 publications

References 13 publications

Evaluation of Dermatologic Therapy

Evaluation of Dermatologic Therapy

Percutaneous Salicylic Acid Intoxication in Psoriasis

Comparative Tissue Absorption of Oral ¹⁴C‐Aspirin and Topical Triethanolamine ¹⁴C‐Salicylate in Human and Canine Knee Joints

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Studies on Ointments

Cited by 11 publications

References 13 publications

Evaluation of Dermatologic Therapy

Evaluation of Dermatologic Therapy

Percutaneous Salicylic Acid Intoxication in Psoriasis

Comparative Tissue Absorption of Oral 14C‐Aspirin and Topical Triethanolamine 14C‐Salicylate in Human and Canine Knee Joints

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Product

Resources

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Comparative Tissue Absorption of Oral ¹⁴C‐Aspirin and Topical Triethanolamine ¹⁴C‐Salicylate in Human and Canine Knee Joints