Studies on New Activities of Enantiomers of 2-(2-Hydroxypropanamido) Benzoic Acid: Antiplatelet Aggregation and Antithrombosis

Zhang, Qili; Wang, Danlin; Zhang, Meiyan; Zhao, Yunli; Yu, Zhiguo

doi:10.1371/journal.pone.0170334

Cited by 4 publications

(4 citation statements)

References 33 publications

(29 reference statements)

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“…The marine yeast-derived R-/S-2-(2-Hydroxypropanamido) benzoic acid (R-/S-HPABA) and the extracts of the alga Eisenia bicyclis were shown to reduce thrombus weight in rats and/or mice and exert a strong inhibition of platelet aggregation in vitro [58,59]. These effects appear to be mediated through distinct mechanisms: R-/S-HPABA likely inhibits cyclooxygenase-1 (COX-1) activity and thromboxane B2 (TXB2) formation, while Eisenia extracts reduce P2Y 12 downstream signalling, a process crucial in platelet activation and aggregation [58,59].…”

Section: Pre-clinical In Vivo Studies On Marine Compounds For Cvds Tr...mentioning

confidence: 99%

Marine Compounds and Age-Related Diseases: The Path from Pre-Clinical Research to Approved Drugs for the Treatment of Cardiovascular Diseases and Diabetes

Giuliani,

Bigossi,

Lai

et al. 2024

Marine Drugs

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Ageing represents a main risk factor for several pathologies. Among them, cardiovascular diseases (CVD) and type 2 diabetes mellitus (T2DM) are predominant in the elderly population and often require prolonged use of multiple drugs due to their chronic nature and the high proportion of co-morbidities. Hence, research is constantly looking for novel, effective molecules to treat CVD and T2DM with minimal side effects. Marine active compounds, holding a great diversity of chemical structures and biological properties, represent interesting therapeutic candidates to treat these age-related diseases. This review summarizes the current state of research on marine compounds for the treatment of CVD and T2DM, from pre-clinical studies to clinical investigations and approved drugs, highlighting the potential of marine compounds in the development of new therapies, together with the limitations in translating pre-clinical results into human application.

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Section: Pre-clinical In Vivo Studies On Marine Compounds For Cvds Tr...mentioning

confidence: 99%

Marine Compounds and Age-Related Diseases: The Path from Pre-Clinical Research to Approved Drugs for the Treatment of Cardiovascular Diseases and Diabetes

Giuliani,

Bigossi,

Lai

et al. 2024

Marine Drugs

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“…Significantly, R-/S-HPABA inhibited the thromboxane B2 level and elevated F1α generation. In addition, R-/S-HPABA could lower the weight of carotid thrombosis ( 35 ).…”

Section: Organic Small Moleculesmentioning

confidence: 99%

Marine Natural Products and Coronary Artery Disease

Liang

Cai

2021

Front. Cardiovasc. Med.

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Coronary artery disease is the major cause of mortality worldwide, especially in low- and middle-income earners. To not only reduce angina symptoms and exercise-induced ischemia but also prevent cardiovascular events, pharmacological intervention strategies, including antiplatelet drugs, anticoagulant drugs, statins, and other lipid-lowering drugs, and renin–angiotensin–aldosterone system blockers, are conducted. However, the existing drugs for coronary artery disease are incomprehensive and have some adverse reactions. Thus, it is necessary to look for new drug research and development. Marine natural products have been considered a valuable source for drug discovery because of their chemical diversity and biological activities. The experiments and investigations indicated that several marine natural products, such as organic small molecules, polysaccharides, proteins, and bioactive peptides, and lipids were effective for treating coronary artery disease. Here, we particularly discussed the functions and mechanisms of active substances in coronary artery disease, including antiplatelet, anticoagulant, lipid-lowering, anti-inflammatory, and antioxidant activities.

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“…R -/ S -2-(2-Hydroxypropanamido) benzoic acid ( R -/ S -HPABA) is a small organic molecule ( Figure 5 D) with anti-inflammatory and analgesic properties [ 40 ]. It was first isolated from the fermentation broth of marine fungus Penicillium chrysogenum .…”

Section: Marine Antithromboticsmentioning

confidence: 99%

“…Moreover, this benzoic acid derivative has COX 1 inhibitory potential, which seems to be stereoselective, since the S isomer was found to be more efficient than the R isomer. The study proposed that the antithrombotic activity of the molecule was somewhat correlated with the inhibition of COX 1 activity [ 40 ].…”

Section: Marine Antithromboticsmentioning

confidence: 99%

Marine Antithrombotics

Dwivedi

Pomin

2020

Marine Drugs

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Thrombosis remains a prime reason of mortality worldwide. With the available antithrombotic drugs, bleeding remains the major downside of current treatments. This raises a clinical concern for all patients undergoing antithrombotic therapy. Novel antithrombotics from marine sources offer a promising therapeutic alternative to this pathology. However, for any potential new molecule to be introduced as a real alternative to existing drugs, the exhibition of comparable anticoagulant potential with minimal off-target effects must be achieved. The relevance of marine antithrombotics, particularly sulfated polysaccharides, is largely due to their unique mechanisms of action and lack of bleeding. There have been many investigations in the field and, in recent years, results have confirmed the role of potential marine molecules as alternative antithrombotics. Nonetheless, further clinical studies are required. This review covers the core of the data available so far regarding the science of marine molecules with potential medical applications to treat thrombosis. After a general discussion about the major biochemical steps involved in this pathology, we discuss the key structural and biomedical aspects of marine molecules of both low and high molecular weight endowed with antithrombotic/anticoagulant properties.

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Studies on New Activities of Enantiomers of 2-(2-Hydroxypropanamido) Benzoic Acid: Antiplatelet Aggregation and Antithrombosis

Cited by 4 publications

References 33 publications

Marine Compounds and Age-Related Diseases: The Path from Pre-Clinical Research to Approved Drugs for the Treatment of Cardiovascular Diseases and Diabetes

Marine Compounds and Age-Related Diseases: The Path from Pre-Clinical Research to Approved Drugs for the Treatment of Cardiovascular Diseases and Diabetes

Marine Natural Products and Coronary Artery Disease

Marine Antithrombotics

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