Studies on Natural Desmutagens: Screening for Vegetable and Fruit Factors Active in Inactivation of Mutagenic Pyrolysis Products from Amino Acids

Morita, Kazuyoshi; Hara, Masako; Kada, Tsuneo

doi:10.1080/00021369.1978.10863139

Cited by 21 publications

(20 citation statements)

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“…Ginger extract and its constituents were tested for their mutagenic (Nakamura and Yamamoto, 1982;Nagabhushan et al, 1987) and anti-mutagenic properties Morita et al, 1978). The literature is replete with data on the acute toxicity and the potential toxicity of plants of medicinal importance (De-Smet, 1991;Atawodi and Spiegelhalder, 1994), but very few systematic studies have been conducted previously on the in vivo genotoxic activities of such plants.…”

Section: Introductionmentioning

confidence: 99%

Clastogenic effect of ginger rhizome in mice

Mukhopadhyay

Mukherjee

2000

Phytother. Res.

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Section: Introductionmentioning

confidence: 99%

Clastogenic effect of ginger rhizome in mice

Mukhopadhyay

Mukherjee

2000

Phytother. Res.

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“…Early studies reported desmutagenic effects against mutagenic pyrolysis products [Morita et al, 1978;Natake et al, 1989]; more recently, mint was shown to inhibit carcinogenesis in the hamster cheek pouch [Samman et al, 1998]. Luteolin, from peppermint, was identified as a strong antimutagen against the heterocyclic amine 3-amino-1-methyl-5H-pyrido [4,3-b]indole (Trp-P-2) [Samejima et al, 1995], whereas another constituent of peppermint, pulegone, has been recognized as a potential hepatotoxin [Nair, 2001].…”

Section: Discussionmentioning

confidence: 99%

Antimutagenic activity of spearmint

Yu¹,

Xu²,

Dashwood

2004

Environ and Mol Mutagen

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The antimutagenic activity of spearmint (Mentha spicata), a popular food flavoring agent, was studied in the Salmonella assay. Spearmint leaves were brewed in hot water for 5 min at concentrations up to 5% (w/v), and the water extracts were tested against the direct-acting mutagens 4-nitro-1,2-phenylenediamine (NPD) and 2-hydroxyamino-3-methyl-3H-imidazo[4,5-f]quinoline (N-OH-IQ) using Salmonella typhimurium strain TA98. Nontoxic concentrations of spearmint extract inhibited the mutagenic activity of N-OH-IQ in a concentration-dependent fashion, but had no effect against NPD. These experiments by design focused on the water extract consumed commonly as an herbal tea, but chloroform and methanol extracts of spearmint also possessed antimutagenic activity against N-OH-IQ. Water extract of spearmint inhibited the mutagenic activity of the parent compound, 2-amino-3-methyl-3H-imidazo[4,5-f]quinoline (IQ), in the presence of rat liver S9; however, the concentration for 50% inhibition (IC50) against IQ was approximately 10-fold higher than in assays with N-OH-IQ minus S9. At concentrations similar to those used in the Salmonella assays, spearmint extract inhibited two of the major enzymes that play a role in the metabolic activation of IQ, namely, cytochromes P4501A1 and 1A2, based on ethoxyresorufin O-deethylase and methoxyresorufin O-demethylase assays in vitro. In vivo, rats were given spearmint water extract (2%; w/v) as the sole source of drinking fluid before, during, and after 2-week treatment with IQ; colonic aberrant crypt foci were inhibited significantly at 8 weeks (P < 0.05, compared with rats given IQ alone). Collectively, these findings suggest that spearmint tea protects against IQ and possibly other heterocyclic amines through inhibition of carcinogen activation and via direct effects on the activated metabolite(s).

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“…Kada et ale (28) and Morita et ale (36) demonstrated that tissue preparations from various plant ~terials were capable of deactivating the mutagenicity of tryptophan pyrolysis products. …”

Section: Deactivation Of Mutagens By Plantsmentioning

confidence: 98%