Studies on Metabolites of Mycoparasitic Fungi. III. New Sesquiterpene Alcohol from Trichoderma koningii.

Sesquiterpenoids from the Endophytic Fungus Trichoderma sp. PR‐35 of Paeonia delavayi

“…2 , six CH (two oxygenated and one olefinic) groups, and two quaternary C-atoms (one olefinic). These data showed similarities to those of trichoacorenol [13], except for the absence of the CH 2 were also observed in the HMBC experiment. Therefore, the CH signal at d(C) 74.2 was assigned to C(2), substituted by an OH group.…”

Two New Sesquiterpenes from the Marine Fungus Eutypella scoparia FS26 from the South China Sea

“…Based on the above spectral evidences, the structure of 1 was elucidated as 3,7,10-trihydroxy-6,11-cyclofarnes-1-ene. C-NMR spectra of 2 were similar to those of the reported acorane-type sesquiterpene trichoacorenol (6) which had been isolated from Trichoderma koningii [13] Fig. 2, and the observed HMBCs from CH 2 (15) to C(7), C(8), and C(9), and 3 J HMBC cross-peaks observed from HÀC(7), HÀC(9), HÀC(11), and Me(14) to quaternary C-atom C(5) further confirmed the formula for 2 (Fig.…”

“…The coupling constants of HÀC(6) (dd, J ¼ 13.4, 10.2) revealed characteristic geminal and trans-diaxial relationships, indicating the axial orientiation of HÀC(6) (d(H) 1.35) and HÀC(7). The HÀC (7) showed NOE correlations with HÀC(11) and Me (13), and Me(14) exhibited NOE correlation with H ax ÀC(6), indicating an a-oriented OH group at C(7). Based on the above spectral evidences, the structure of 2 was established as 8-(hydroxymethyl)-1-(1-hydroxy-1-methylethyl)-4-methylspiro[4.5]dec-8-en-7-ol with a yet undetermined absolute configuration and relative configuration at C(11).…”

Colletoic Acid, a Novel 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor from Colletotrichum gloeosporioides SANK 21404

“…Among them, the structures of 3-hydroxy-4-acorene [9], alaskene and acoradiene from liverwort [10], tricho-acorenol from Trichoderma koningii [11], acorenones [12] and AC-1 through AC-4 [13] from rhizome of calamus (Acorus calamus), acorenone-B from Bothriochloa intermedia [14] were noted to be similar to that of colletoic acid. However, their planar structures were distinct from that of colletoic acid, which was fully oxidized to carboxylic acid at C-11.…”