Studies on Mechanisms of the Action of Androgens on Prostate

Shida, Keizo; Shimazaki, Jun; Urano, E; Kojima, Hiroshi; Takahashi, Hiroshi

doi:10.5980/jpnjurol1928.63.1_27

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“…CMA (C 23 H 29 ClO 4 , ASKA Pharmaceutical Co., Ltd., Tokyo, Japan) is a widely used AA in Japan and has a steroidal structure. CMA works as a progestational AA that suppresses pituitary luteinizing hormone (LH), thus reducing testicular androgen production [6]. CMA is similar to cyproterone acetate (C 24 H 29 ClO 4 , Bayer PLC, Newbury, United Kingdom), an antiandrogen widely used in Europe, United States, Canada, Mexico, and other countries.…”

Section: Medicinesmentioning

confidence: 99%

Effects of Steroidal Antiandrogen or 5-alpha-reductase Inhibitor on Prostate Tissue Hormone Content

et al. 2017

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Section: Medicinesmentioning

confidence: 99%

Effects of Steroidal Antiandrogen or 5-alpha-reductase Inhibitor on Prostate Tissue Hormone Content

et al. 2017

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Synergistic effects of estrogen with androgen on the prostate—effects of estrogen on the prostate of androgen‐administered rats and 5‐alpha‐reductase activity

et al. 1994

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To clarify the effects of estrogen on the prostate of androgen-treated rats, we administered estradiol (E2; 0.01 mg/day) to testosterone (T; 1 mg/day)-treated Wistar rats under various conditions. There were three variable factors: the age of the rat, the untreated period after castration, and the presence of testes. Under all conditions, E2 stimulated the growth of the prostate in T-treated rats compared with growth in rats in treated with T only. To analyze the mechanism underlying this enhancement of prostate growth by estrogen, we measured 5-alpha-reductase activity and calculated its kinetic parameters, i.e., both Vmax and Km. The Vmax of the nuclear fraction was higher in E2-administered T-treated rats than in T only-treated rats. In contrast, the Vmax of the microsomal fraction was lower in E2-administered rats. Km values in the two groups showed no significant differences. Elevation of the nuclear fraction of 5-alpha-reductase activity could explain the synergistic effects of estrogen on the prostate growth of androgen-treated rats.

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Studies on Mechanisms of the Action of Androgens on Prostate

Cited by 2 publications

References 0 publications

Effects of Steroidal Antiandrogen or 5-alpha-reductase Inhibitor on Prostate Tissue Hormone Content

Effects of Steroidal Antiandrogen or 5-alpha-reductase Inhibitor on Prostate Tissue Hormone Content

Synergistic effects of estrogen with androgen on the prostate—effects of estrogen on the prostate of androgen‐administered rats and 5‐alpha‐reductase activity

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