Synergistic effects of estrogen with androgen on the prostate—effects of estrogen on the prostate of androgen‐administered rats and 5‐alpha‐reductase activity

Suzuki, Kazuhiro; Takezawa, Yutaka; Suzuki, Takanori; Honma, Sato; Yamanaka, Hidetoshi

doi:10.1002/pros.2990250402

Cited by 33 publications

(25 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Human, dog, and rat prostate epithelial cells express both androgen and estrogen receptors and, consistent with these findings, there is evidence in both dogs [15,16] and rats [17][18][19] that estradiol acts synergistically with testosterone to cause overgrowth of the prostate. In fact, we have observed a synergistic effect of combined treatment with estradiol and testosterone on dorsal and lateral prostate overgrowth in Brown Norway rats [20].…”

Section: Discussionsupporting

confidence: 59%

Age-Dependent and Lobe-Specific Spontaneous Hyperplasia in the Brown Norway Rat Prostate1

Banerjee¹,

Banerjee²,

Lai³

et al. 1998

Biology of Reproduction

View full text Add to dashboard Cite

We showed previously that exogenously administered testosterone caused age- and lobe-specific overgrowth of the prostate in Brown Norway rats. A common feature observed in testosterone-treated animals was cell hypertrophy in each of the ventral, dorsal, and lateral lobes of both young (6 mo old) and old (24 mo old) rats. By contrast, hyperplasia was seen only in the dorsal and lateral lobes of old rats treated with testosterone. These observations prompted us to examine whether age- and lobe-specific overgrowth might also occur in untreated rats as a consequence of the endogenous hormonal milieu. To this end, blood and prostates were collected from a large number (25-30 rats per group) of 4- to 6-mo-old (young) and 21- to 24-mo-old (old) Brown Norway rats. Both serum testosterone (-45%) and estradiol (-22%) concentrations decreased significantly with age, but the greater magnitude of the decrement in testosterone relative to estradiol led to a reduction in the serum testosterone:estradiol ratio. Paradoxically, although the prostate is androgen dependent, the wet weight, protein, and DNA contents increased significantly with age in the dorsal and lateral lobes of old rats despite the decrease in testosterone level. Histologic examination revealed that the increased weights and DNA contents of the dorsal and lateral lobes in old rats coincided with an increased number of epithelial cells in the distal and intermediate segments of these lobes, indicative of hyperplasia but independent of change in cell size. Taken together, these results show a spontaneous age-related overgrowth of cells in the dorsal and lateral prostatic lobes of old Brown Norway rats despite diminished serum testosterone concentrations. The aging Brown Norway rat, therefore, may be a useful model for studies of some aspects of the pathogenesis underlying spontaneous age-related prostatic hyperplasia.

show abstract

Section: Discussionsupporting

confidence: 59%

Age-Dependent and Lobe-Specific Spontaneous Hyperplasia in the Brown Norway Rat Prostate1

Banerjee¹,

Banerjee²,

Lai³

et al. 1998

Biology of Reproduction

View full text Add to dashboard Cite

show abstract

“…It has been demonstrated that combined administration of androgen and estrogen synergistically enhanced the development of prostatic hyperplasia and cancer in Noble rats as well as in chemical carcinogen-treated F344 rats [27,28]. In the previous study, we examined the expression of prostatic protein genes such as probasin and kallikrein S3 to understand the molecular mechanism underling the androgen plus estrogen effect [29].…”

Section: Discussionmentioning

confidence: 98%

Androgen dependent transcription of a mouse prostatic protein gene, PSP94: Involvement of estrogen receptors

Fujimoto

Kawa

Kanno

2011

The Journal of Steroid Biochemistry and Molecular Biology

View full text Add to dashboard Cite

“…The protocol to induce BPH was conducted according to Suzuki et al (1994) with slight modification [29]. Briefly, in the beginning of week 2, all healthy controls (groups 1, 3, 5, and 7) were s.c. administered 20 μ L mineral oil/head/day as placebo.…”

Section: Methodsmentioning

confidence: 99%

Action Mechanism ofGinkgo bilobaLeaf Extract Intervened by Exercise Therapy in Treatment of Benign Prostate Hyperplasia

Peng

Liu

Chang

et al. 2013

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Benign prostatic hyperplasia (BPH), an imbalance between androgen/estrogen, overexpression of stromal, and epithelial growth factors associated with chronic inflammation, has become an atypical direct cause of mortality of aged male diseases. Ginkgo possesses anti-inflammatory, blood flow-enhancing, and free radical scavenging effects. Considering strenuous exercise can reduce BPH risks, we hypothesize Ginkgo + exercise (Ginkgo + Ex) could be beneficial to BPH. To verify this, rat BPH model was induced by s.c. 3.5 mg testosterone (T) and 0.1 mg estradiol (E2) per head per day successively for 8 weeks, using mineral oil as placebo. Cerenin® 8.33 μL/100 g was applied s.c. from the 10th to the 13th week, and simultaneously, Ex was applied (30 m/min, 3 times/week). In BPH, Ginkgo alone had no effect on T, 5α-reductase, and dihydrotestosterone (DHT), but suppressed androgen receptor (AR), aromatase, E2 and estrogen receptor (ER), and the proliferating cell nuclear antigen (PCNA); Ex alone significantly reduced T, aromatase, E2, ER, AR, and PCNA, but highly raised DHT. While Ginkgo + Ex androgenically downregulated T, aromatase, E2, and ER, but upregulated DHT, AR, and PCNA, implying Ginkgo + Ex tended to worsen BPH. Conclusively, Ginkgo or Ex alone may be more beneficial than Ginkgo + Ex for treatment of BPH.

show abstract

Synergistic effects of estrogen with androgen on the prostate—effects of estrogen on the prostate of androgen‐administered rats and 5‐alpha‐reductase activity

Cited by 33 publications

References 20 publications

Age-Dependent and Lobe-Specific Spontaneous Hyperplasia in the Brown Norway Rat Prostate1

Age-Dependent and Lobe-Specific Spontaneous Hyperplasia in the Brown Norway Rat Prostate1

Androgen dependent transcription of a mouse prostatic protein gene, PSP94: Involvement of estrogen receptors

Action Mechanism ofGinkgo bilobaLeaf Extract Intervened by Exercise Therapy in Treatment of Benign Prostate Hyperplasia

Contact Info

Product

Resources

About