Studies on local anesthetic lidocaine hydrochloride delivery via photo-triggered implantable polymeric microneedles as a patient-controlled transdermal analgesia system

Li, Yafeng; Liao, Xiaoxiang; Bin, Zheng

doi:10.1080/09205063.2021.1981535

Cited by 5 publications

(4 citation statements)

References 38 publications

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“…The active target of topical anesthetics is dermal nerve fibers, so topical anesthetics have to penetrate the stratum corneum. 10 Traditional transdermal administration can avoid the first-pass effect of liver and the degradation of drugs in the gastrointestinal tract, but due to the barrier effect of the stratum corneum, there is a limitation of low skin permeability. 11 At present, there are many methods to improve skin permeability of topical anesthetics, shorten the onset time, and enhance the anesthesia effect, such as iontophoresis, 12 electroporation, 13 and sonophoresis.…”

Section: Discussionmentioning

confidence: 99%

“…There are limitations such as slow effect, long waiting time, and short duration. The active target of topical anesthetics is dermal nerve fibers, so topical anesthetics have to penetrate the stratum corneum 10 . Traditional transdermal administration can avoid the first‐pass effect of liver and the degradation of drugs in the gastrointestinal tract, but due to the barrier effect of the stratum corneum, there is a limitation of low skin permeability 11 .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Roller microneedles transdermal delivery of compound lidocaine cream for enhancing the analgesic effect: A randomized self‐controlled trial

Hanlin

Wanyue

Zhang

et al. 2022

J of Cosmetic Dermatology

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Objective: The purpose of this article is to investigate whether the percutaneous delivery of compound lidocaine cream by roller microneedles can shorten the minimal effective onset time of anesthesia, enhance the intensity of anesthesia and prolong the analgesic time, so as to provide a theoretical basis for exploring a comfortable, safe and effective anesthesia method for photoelectric cosmetic surgery.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Roller microneedles transdermal delivery of compound lidocaine cream for enhancing the analgesic effect: A randomized self‐controlled trial

Hanlin

Wanyue

Zhang

et al. 2022

J of Cosmetic Dermatology

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“…Li et al. prepared phototriggered lidocaine microneedles using iron oxide nanoparticles (Fe3O4NPs) coated with polydopamine (PDA), polyvinylpyrrolidone (PVP) and polycaprolactone (PCL) to achieve painless and effective transdermal drug delivery by programmed release of lidocaine (Li Y et al., 2022 ). In additional studies, dual-network microgels carrying ropivacaine were prepared using polymers, such as polyethylene glycol (PEG), with graphene oxide (GO).…”

Section: Local Anesthetic Compound Delivery Systemmentioning

confidence: 99%

Advances in the use of local anesthetic extended-release systems in pain management

Chen,

Xu,

et al. 2023

Drug Delivery

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Pain management remains among the most common and largely unmet clinical problems today. Local anesthetics play an indispensable role in pain management. The main limitation of traditional local anesthetics is the limited duration of a single injection. To address this problem, catheters are often placed or combined with other drugs in clinical practice to increase the time that local anesthetics act. However, this method does not meet the needs of clinical analgesics. Therefore, many researchers have worked to develop local anesthetic extended-release types that can be administered in a single dose. In recent years, drug extended-release systems have emerged dramatically due to their long duration and efficacy, providing more possibilities for the application of local anesthetics. This paper summarizes the types of local anesthetic drug delivery systems and their clinical applications, discusses them in the context of relevant studies on local anesthetics, and provides a summary and outlook on the development of local anesthetic extended-release agents.

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“…LID performance could be improved by nanotechnology approaches that could increase resistance time on the skin, in order to allow the penetration into corneum stratum and pain receptors underlying desensitization [ 2 , 3 , 4 , 5 ]. Nanoscale drug delivery systems (DDS) have been designed as inert systems that can transport drugs at the target site with high selectivity and controllable kinetic release profile [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Lidosomes: Innovative Vesicular Systems Prepared from Lidocaine Surfadrug

Romeo

Mazzotta²,

Perrotta³

et al. 2022

Pharmaceutics

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Lidocaine is a local anaesthetic drug with an amphiphilic structure able to self-associate, under certain conditions, in molecular aggregates playing the role of both carrier and drug. The aim of this study was to determine the optimal conditions for obtaining vesicular carriers, called lidosomes. The new formulations were obtained using both lidocaine and lidocaine hydrochloride and different hydration medias (distilled water, acid, and basic aqueous solution). Lidosomes formulations were characterized in terms of size, ζ-potential, drug retained, stability formulation, and ex vivo permeation profile. Moreover, lidosomes were incorporated in two different gel structures: one based on carboxymethylcellulose and one based on pluronic F-127 to achieve suitable properties for a topical application. Results obtained showed that lidocaine showed a better performance to aggregate in vesicular carriers in respect to hydrochloride form. Consequently, only formulations comprised of lidocaine were studied in terms of skin permeation performance and as carriers of another model drug, capsaicin, for a potential combined therapy. Lidocaine, when in form of vesicular aggregates, acted as percutaneous permeation enhancer showing better permeation profiles with respect to drug solutions. Moreover, lidosomes created a significant drug depot into the skin from which the drug was available for a prolonged time, a suitable feature for a successful local therapy.

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Studies on local anesthetic lidocaine hydrochloride delivery via photo-triggered implantable polymeric microneedles as a patient-controlled transdermal analgesia system

Cited by 5 publications

References 38 publications

Roller microneedles transdermal delivery of compound lidocaine cream for enhancing the analgesic effect: A randomized self‐controlled trial

Roller microneedles transdermal delivery of compound lidocaine cream for enhancing the analgesic effect: A randomized self‐controlled trial

Advances in the use of local anesthetic extended-release systems in pain management

Lidosomes: Innovative Vesicular Systems Prepared from Lidocaine Surfadrug

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