Studies On Inner-Ear Function And Cranial Nerves In Diabetics

Jørgensen, M. Balslev; Buch, Nils H.

doi:10.3109/00016486109126500

Cited by 111 publications

(61 citation statements)

References 3 publications

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“…Although an early hearing impairment in diabetes and the initial site of damage are still matters of controversy (1)(2)(3)(4)(5)(6)(7)(8), a causal relationship between hearing impairment and diabetes has been claimed on the basis of several investigations, indicating an incidence of hearing impairment of up to 93% in diabetic subjects (1,22,23).…”

Section: Conclusion-mentioning

confidence: 99%

Distortion-Product Otoacoustic Emissions and Selective Sensorineural Loss in IDDM

Ghirlanda

Paludetti

et al. 1998

Diabetes Care

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Our results suggest that IDDM patients show an early abnormality of the micromechanical properties of the OHCs. In IDDM patients without a subclinical peripheral neuropathy, damage is limited to the higher frequencies and can be detected only by DPOAEs, whereas in IDDM patients with neuropathy, damage also involves the middle range of frequencies and can be detected by TEOAEs and DPOAEs. Therefore, DPOAEs seem to be able to detect the earliest cochlear selective-frequency dysfunction in IDDM patients without peripheral neuropathy. DPOAEs appear to be of greater clinical interest than TEOAEs; the former seem to be frequency specific and can be recorded at any chosen frequency, including high frequencies.

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Section: Conclusion-mentioning

confidence: 99%

Distortion-Product Otoacoustic Emissions and Selective Sensorineural Loss in IDDM

Ghirlanda

Paludetti

et al. 1998

Diabetes Care

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“…They concluded that a wide range of in vivo and in vitro studies present data consistent with this assumption, and further suggest that the synthesis of the basement membrane and tissue regeneration are increased in diabetes while basement membrane degradation is reduced or impaired 42 . The authors of a study done on the temporal bones of 32 individuals of various ages 43 found that PAS-stained blood vessels of the stria vascularis revealed interesting findings. They found massive lamellar deposits of PAS on the capillary walls of the stria vascularis ten to twenty times thicker than usual.…”

Section: Histology Changesmentioning

confidence: 99%

Estudo da prevalência de hipoacusia em indivíduos com diabetes mellitus tipo 1

Malucelli¹,

Malucelli²,

Fonseca³

et al. 2012

Braz. j. otorhinolaryngol.

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Diabetes mellitus (DM) is a chronic degenerative disease that impairs normal insulin production and use. DM chronic auditory complications may include spiral ganglion atrophy, degeneration of the vestibulocochlear nerve myelin sheath, reduction of the number of spiral lamina nerve fibers, and thickening of the capillary walls of the stria vascularis and small arteries. Objective This paper aims to verify the hearing thresholds of individuals with type 1 DM. Materials and Methods Sixty patients were enrolled in this trial and divided into case and control groups featuring diabetic and non-diabetic subjects respectively. All individuals were interviewed and underwent physical examination, ENT examination, and audiometric tests. Results Statistically significant difference was observed in hearing thresholds of case group subjects at 250, 500, 10,000, 11,200, 12,500, 14,000 and 16,000 Hz for both ears and ear average. Case group subjects had higher likelihood of having hypacusis at any frequency regardless of ear than controls. Conclusion Statistically significant differences were seen in the audiological findings of case group subjects when compared to controls. Thorough audiological examination including high frequency audiometry is required for subjects with diabetes mellitus type 1.

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“…In fact, altered hearing in diabetic patients has been detected as early as the 1960s (2,3), yet the pathogenesis of diabetic hearing loss still remains only partially understood (4). In addition to previous studies on the loss of outer hair cells in the cochlea (5,6), recent morphologic studies suspect that microangiopathy plays a role in the diabetic inner ear (7,8).…”

mentioning

confidence: 95%