Distortion-Product Otoacoustic Emissions and Selective Sensorineural Loss in IDDM

W, Di Nardo; Ghirlanda, Giovanni; Paludetti, Gaetano; Cercone, Stefania; Saponara, C; M, Del Ninno; Girolamo, Stefano Di; Magnani, Paolo; Leo, Di

doi:10.2337/diacare.21.8.1317

Cited by 32 publications

(32 citation statements)

References 24 publications

(38 reference statements)

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“…DPOAE was reduced below 2SD of control mean in 32% of diabetic patients, however no significant association between EOAEs and duration and control of diabetes was found. 11 The results of study conducted by Eren et al were contradictory to present study, in which no statistically significant difference is there between DPOAE amplitude (Ldp) between 40 diabetics and 24 control group in frequencies 1, 2, 2.5, 3,4, 5, 6, 7, and 8 kHz, however small study group can be a limitation of their study. 15 Bayindir et al investigated role of glycaemic control on outer hair cell functions.…”

Section: Discussioncontrasting

confidence: 54%

“…It is observed that the TEOAE recordings are not very frequency selective as compared to DPOAE. 10,11 In the present study, mean DPOAE SNR values for diabetics were lower in all frequencies [2000, 3000, 4000, 5000 and 6000 Hz] for diabetics. An early onset high frequency cochlear dysfunction in diabetics was indicated by lower SNR values with significant decrease for 4, 5 and 6 kHz.…”

Section: Discussionmentioning

confidence: 75%

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A comparative study on effects of diabetes on auditory functions as measured by BERA and DPOAE

Joshi¹,

Galagali

Kanzhuly

et al. 2017

Int J Otorhinolaryngol Head Neck Surg

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Background: Diabetes is prevalent endocrine disorder associated with many complications. However, the link between auditory dysfunctions and diabetes is still vague. The current study aims to correlate auditory dysfunction caused by DM, measured by distortion product otoacoustic emission (DPOAE) & brainstem evoked otoacoustic emissions (BERA). Methods: This is a descriptive (comparative) study in which auditory functions of 100 diabetics and 100 matched non-diabetics were assessed by distortion product otoacoustic emission (DPOAE) & brainstem evoked otoacoustic emissions (BERA). The data for diabetic and non- diabetic group was compared and analysed. Effects of age of individual on auditory functions were also analysed separately using suitable statistical tests. The data collected was analysed with suitable statistical tests were performed with a significance level of ɑ=0.1 using SPSS 2.0 software. Results: The demographical variable was comparable in both the groups. The results showed decline in free field hearing, which are further adversely affected by duration of diabetes and patient’s age. The pure tone thresholds were not significantly higher in diabetics; however the thresholds were significantly higher in diabetics in older age groups. The hearing loss appear at early age in diabetics but gradually become indistinguishable from age related hearing loss. Conclusions: Although the auditory dysfunction can be linked to diabetes, but are usually not detectable at earliest stages with routine clinical and audiological tests. The DPOAE and BERA have role to play in monitoring of the auditory dysfunction.

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Section: Discussioncontrasting

confidence: 54%

Section: Discussionmentioning

confidence: 75%

A comparative study on effects of diabetes on auditory functions as measured by BERA and DPOAE

Joshi¹,

Galagali

Kanzhuly

et al. 2017

Int J Otorhinolaryngol Head Neck Surg

View full text Add to dashboard Cite

show abstract

“…The study conducted by Di Nardo et al 1998 [22] demonstrated that it was possible to verify a relationship between neuropathy and the amplitude of TOAE, as well as with the frequencies from 1 to 5 kHz of the DPOAE. However, in the group without neuropathy the correlation only occurred in frequencies from 3 to 5 kHz of DPOAE.…”

Section: Cochlear Dysfunction In Type 1 Dmmentioning

confidence: 99%

Dysfunction of the peripheral and central auditory pathway in patients with type 1 diabetes mellitus

Fernandes¹,

Casais-Silva²,

Ladeia³

2012

JDM

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Although auditory alterations are not a typical symptom of diabetes mellitus (DM), they can occur in patients with type 1 DM. The findings of previous studies are controversial, because the frequency and degree of hearing loss varies, and quite often alterations are still subclinical. The typical test used to detect and manage hearing loss is the audiogram, but this test alone is only capable of detecting alterations due to injury of the inner hair cells and/or alterations in the central auditory pathway. However, auditory alterations resulting from a dysfunction that is still subclinical are only able to be detected through electrophysiological auditory tests, such as the otoacoustic emissions (OAE) and the auditory brainstem response (ABR) tests. Thus, the purpose of this paper is to review the studies that utilize the OAE and ABR tests, and to verify if the dysfunction is cochlear and/or neural in patients with type 1 DM. The findings of this review demonstrate that patients with type 1 DM can have auditory alterations stemming from a central cochlear origin. Following this finding, early diagnosis is very important in order to implement preventative treatments and initiate therapy.

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“…Hastalarda akustik şikayetler gelişmeden çok önce ABR değişiklikleri izlenebilir (10). ABR deki bozulmalar hastalığın süresi ile yakından ilişkilidir (6). Bununla birlikte periferik nöropatisi ve yaygın hastalığı olanlarda daha bozulmuş ABR sonuçları izlenmiştir (6).…”

unclassified

“…ABR deki bozulmalar hastalığın süresi ile yakından ilişkilidir (6). Bununla birlikte periferik nöropatisi ve yaygın hastalığı olanlarda daha bozulmuş ABR sonuçları izlenmiştir (6). Diabetik ensefalopatinin değerlendirilmesinde ve hastalığın yaygınlığının anlaşılabilmesinde ABR, IDDM'ta yararlı olabilir.…”

unclassified

Tip 1 Diyabetli Hastalarda ABR Sonuçlarının Normal Popülasyonla Karşılaştırılması

Elbistanlı¹,

Gürkan²,

Yurtsever³

et al. 2013

Haseki

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ÖzetAmaç: İnsüline bağımlı diyabet (IDDM) hastalarında ABR sonuçlarının değerlendirilmesi. Yöntem:IDDM tanısıyla takip edilen 18 ile 48 yaş arasındaki 19'u kadın, 12'si erkek 31 olgunun 62 kulağı çalışmaya dahil edildi. Olguların ortalama yaşı 32 olarak bulundu. Kontrol grubu 10 erkek ve 10 kadından oluşan ve yaşları 24 ile 43 arasında değişen (ort.30), herhangi bir otolojik problemi olmayan gönüllü katılımcılardı. IDDM'li hastaların 70 desibel(dB) normal işitme seviyesindeki (nHL) I, III, V dalga latansları ve I-III, I-V, III-V intervalleri diğer kulak ve kontrol grubuyla karşılaştırıldı. Bulgular: IDDM grubunun sağ ve sol kulaklarında I. ve V. dalga latansları ve I-V intervali kontrol grubuna göre anlamlı derecede yüksek bulunmuştur. (p<0.05). IDDM grubunun sağ ve sol kulaklarının I. , III. , V. dalgaları ve I-III, III-V ve I-V intervallerinin ortalamalarının birbirleriyle karşılaştırılması sonucunda istatistiksel olarak anlamlı bir fark bulunamamıştır (p>0.05). Sonuç: IDDM ABR de anormal bulgular gözlenmesine yol açar. IDDM'li hastalarda ABR sonuçlarının daha iyi standardize edilmesine ve sistematik bir sınıflandırmaya ihtiyaç vardır. Bu sayede IDDM'nin hastalarda yarattığı merkezi sinir sistemi ve kokleovestibüler hasarın daha iyi anlaşılması mümkün olabilir. (Ha se ki T›p Bül te ni 2013; 51: 36-40) Anahtar Kelimeler: Diyabet, insülin bağımlı, ABR Abs tract Aim: Evaluation of ABR results in patients with insulin dependent diabetes mellitus (IDDM).Methods: ABR results of 31 patients with IDDM (19 female, 12 male) were compared with ABR results of 20 healthy volunteers (10 female, 10 male). Mean patient age was 32 (range: 18-48) years in study group and 30 (range: 24-43) years in control group. All tests were performed bilaterally. Ist, IIIrd, Vth wave latencies and I-III, III-V, I-V intervals at 70 dB normal hearing level ( dB nHL) were compared.Results:I st and V th wave latencies and I-V intervals of right and left ears of study group were significantly different from the control group (p<0.05). Regarding I. III. V. wave latencies and I-III, III-V, I-V intervals between right and left ears of control group were not significant (p>0.05).Conclusion: IDDM results in abnormal ABR findings. Standardization and systematic classification of ABR results in IDDM patients is required in order to predict central nervous system and cochlea-vestibular damages. (The Me di cal Bul le tin of Ha se ki 2013; 51: 36-40)

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Distortion-Product Otoacoustic Emissions and Selective Sensorineural Loss in IDDM

Cited by 32 publications

References 24 publications

A comparative study on effects of diabetes on auditory functions as measured by BERA and DPOAE

A comparative study on effects of diabetes on auditory functions as measured by BERA and DPOAE

Dysfunction of the peripheral and central auditory pathway in patients with type 1 diabetes mellitus

Tip 1 Diyabetli Hastalarda ABR Sonuçlarının Normal Popülasyonla Karşılaştırılması

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