Studies on Human Proteinuria. Ii. Some Characteristics of the Gamma Globulins Excreted in Normal, Exercise, Postural, and Nephrotic Proteinuria*

McKay, Erin; Slater, Robert

doi:10.1172/jci104621

Cited by 27 publications

(9 citation statements)

References 14 publications

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“…After exercise is stopped, it declines exponentially, with a half-time of about 56 min [4]. The major component of postexercise proteinuria is albumin, together with a lesser amount of lower or higher-molecu lar-weight proteins such as transferrin and immunoglob ulin G. Although these quantitative and qualitative changes have been extensively studied [5,6], the mecha nism of postexercise proteinuria remains unclear. It seems to result mainly from increased filtration of plasma proteins and to a lesser extent from decreased tubular reabsorption of low-molecular-weight proteins.…”

Section: Introductionmentioning

confidence: 99%

Captopril but Not Acebutolol, Prazosin or Indomethacin Decreases Postexercise Proteinuria

Esnault

Potiron-Josse²,

Testa³

et al. 1991

Nephron

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Strenuous physical exercise causes transient proteinuria and renal hemodynamic changes: decrease of renal blood flow and to a lesser extent of the glomerular filtration rate, and an increase of the filtration fraction. However, the mechanisms of these modifications are still poorly understood. In order to elucidate them we performed maximal exercise tests on 8 untrained healthy volunteers after inhibition of the renin-angiotensin system (RAS) by captopril, the sympathetic nervous system by a β-blocking drug (acebutolol) or an α-blocking drug (prazosin) and the prostaglandin system by indomethacin. Urinary albumin excretion was measured in every subject first at rest (AB) and then after exercise (AA) performed successively without and with blockade by each of theses drugs. AA-AB difference in the captopril test (12.04 ± 6.11 μg/min) compared to that in the control test (68.91 ± 25.18 μg/min) was significantly reduced (p < 0.02). This difference remained unchanged after acebutolol (59.87 ± 21.91 μg/min, p = 0.62), prazosin (35.23 ± 27.80 μg/min, p = 0.21) and indomethacin (55.21 ± 28.43 μg/min, p = 0.35). There was a negative correlation between the lowering of AA elevation and the rise in plasma renin activity in the captopril test (r = 0.64; p < 0.03). Only acebutolol decreased systolic blood pressure significantly. These results suggest that the RAS plays a major role in postexercise proteinuria. We hypothesize that stimulation of this system induces an increase of efferent glomerular artery constriction and consequently of glomerular transcapillary pressure and the filtration fraction. Captopril seems able to prevent these hemodynamic changes.

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Section: Introductionmentioning

confidence: 99%

Captopril but Not Acebutolol, Prazosin or Indomethacin Decreases Postexercise Proteinuria

Esnault

Potiron-Josse²,

Testa³

et al. 1991

Nephron

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“…Immunological investigations have established the presence of several plasma proteins in normal urine, collected from individuals both at rest and after exercise (9)(10)(11)(12)(13). In the latter case, immunoprecipitation techniques showed an increase in the number of plasma proteins (9) as well as in the number of proteins not present in plasma (10).…”

Section: Introductionmentioning

confidence: 99%

Quantitative immunological determination of 12 plasma proteins excreted in human urine collected before and after exercise

Poortmans¹,

Jeanloz²

1968

J. Clin. Invest.

134

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A B S T R A C r Urine was collected from 6 healthy male adults at rest and from 20 male adults after a marathon race (25 miles). The concentrated urines were quantitatively analyzed, by single radial immunodiffusion, for their content in 12 different plasma proteins: tryptophan-rich prealbumin, albumin, a,-acid glycoprotein, a1-antitrypsin, ceruloplasmin, haptoglobin, Gc-globulin, transferrin, hemopexin, f82-glycoprotein I, yA-globulin, and yG-globulin.Albumin, yA-globulin, and yG-globulin represent the major part of the plasma proteins detected in normal urine excreted by humans at rest (12, 0.5, and 2.5 mg respectively, out of a total excretion of 17.5 mg of plasma proteins per 24 hr). The other plasma proteins were excreted at a lower rate (< 0.4 mg/24 hr). The relative content of tryptophan-rich prealbumin, a1-antitrypsin, Gc-globulin, transferrin, and yG-globulin was lower in normal urine than in normal serum, whereas that of al-acid glycoprotein, 82-glycoprotein I, and yA-globulin was higher. The ratio of yG-globulin to yA-globulin was 4.9:1. When plotted on a logarithmic scale, no direct relationship between the molecular weight of a protein and the value of its renal clearance could be observed.

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“…In normal as well as in certain pathological proteinurias -y-globulin, 182A-globulin, and the y-related low molecular weight protein (yL-globulin) have been described by several authors (1)(2)(3)(4)(5)(6)(7)38). Antibody activity demonstrable in urine could be expected to be related to any or all of these immunoglobulins.…”

mentioning

confidence: 99%

Characterization of Antibodies in Human Urine*

Hanson¹,

Tan²

1965

J. Clin. Invest.

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Studies on Human Proteinuria. Ii. Some Characteristics of the Gamma Globulins Excreted in Normal, Exercise, Postural, and Nephrotic Proteinuria*

Cited by 27 publications

References 14 publications

Captopril but Not Acebutolol, Prazosin or Indomethacin Decreases Postexercise Proteinuria

Captopril but Not Acebutolol, Prazosin or Indomethacin Decreases Postexercise Proteinuria

Quantitative immunological determination of 12 plasma proteins excreted in human urine collected before and after exercise

Characterization of Antibodies in Human Urine*

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