Studies on Gastritis in the Upper Portion of Stomach by Endoscopic Congo Red Test

Tatsuta, M; Saegusa, T.; Okuda, S

doi:10.1055/s-0028-1098214

Cited by 37 publications

(29 citation statements)

References 2 publications

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“…Pos sibly, the reason why these cancers are so rare in Japan is related to the extent of the cardiac gland area. As previously reported [12,13], the cardiac gland area is very narrow, if present at all. In 11 (29.7%) out of 37 patients examined, we were unable to detect any car diac glands, and in other patients, the mean width of the cardiac gland area was only 2.2 mm (0.5-9 mm).…”

Section: Discussionsupporting

confidence: 55%

Early Adenocarcinoma of the Gastric Cardia

Tatsuta¹,

Okuda²,

Taniguchi

1985

Oncology

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The relationships of gross and histologic types of early gastric cancer in the upper portion of the stomach, the extent of the normal oxyntic gland area and the grade of intestinal metaplasia in the mucosa surrounding the tumor, to the distance of the tumor from the squamocolumnar junction were examined in 29 specimens obtained at total gastrectomy. There were significant correlations between gross type of early cancer, extent of the normal oxyntic gland areas or the grade of intestinal metaplasia in the surrounding mucosa, and the distance of the tumor from the squamocolumnar junction. Cancers located within 2 cm from the squamocolumnar junction were more frequently polypoid, more frequently associated with a large oxyntic gland area, and less commonly surrounded by profuse intestinal metaplasia. The above differences suggest that cancers located within 2 cm from the squamocolumnar junction differ from those in other regions of the upper portion of the stomach.

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Section: Discussionsupporting

confidence: 55%

Early Adenocarcinoma of the Gastric Cardia

Tatsuta¹,

Okuda²,

Taniguchi

1985

Oncology

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“…Bockus [8] stated that the size of the cardiac gland area was 0.5-3.0 cm, and Netter [17] stated that the size was 0.5-4.0 cm. Furthermore, Tatsuta [24] described the size as being 2 cm in average, ranging from 1.0 to 5.7 cm. Kato et al [13] also reported the cardiac gland area as being 1 cm in size at most.…”

Section: Discussionmentioning

confidence: 99%

Definition of carcinoma of the gastric cardia

Misumi

Murakami

Harada

et al. 1989

Langenbecks Arch Chiv

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This study concerns the definition of carcinoma of the gastric cardia. The topography of the esophagogastric mucosal junction (mucosal EGJ) was investigated with an endoscope in 182 patients who were free of hiatal hernias, ulcers, and neoplasms in the esophagus and stomach. The relationship between the EGJ and the cardiac gland area was then examined histologically in 56 resected specimens containing intact EGJs and cardia gland areas. Furthermore the cancerous center was determined; the shortest distance between the cancerous center and the EGJ and the amount of esophageal invasion were measured in 102 resected carcinomas located close to the junction; the carcinomas contained the EGJ and were good enough for pathohistological examination. The EGJ was located 0.5 - 1.0 cm proximal to the His angle (the gastric cardia) in radiological and endoscopic examinations. Histologically the cardiac gland area was found to straddle the EGJ at a range of about 1 cm proximal and 2 cm distal to the junction. Among the upper stomach carcinomas, most of the tumors (87.5%) whose center was located within 2 cm from the EGJ invaded the esophagus. In conclusion, carcinoma of the gastric cardia is defined as a lesion with its center located within 1 cm proximal and 2 cm distal to the EGJ.

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“…HP-related chronic gastritis usually starts in the antrum and expands proximally towards the body of the stomach (Kimura, 1972;Tatsuta et al, 1973). As several studies dealing with endoscopic biopsies or chromoendoscopic testing have found that progression of chronic atrophic gastritis (CAG) increases the risk of cancer (Meister et al, 1979;Sipponen et al, 1985;Siurala et al, 1966;Tatsuta et al, 1993;Testoni et al, 1987), accurate and reliable evaluation of the extent of CAG is considered important for identifying individuals at high risk of cancer.…”

Section: Serum Pg Testmentioning

confidence: 99%

Gastric Cancer Risk Diagnosis and Prevention in Subjects with Helicobacter pylori-related Chronic Gastritis

Enomoto¹,

Watanabe²,

Mukoubayashi³

et al. 2011

Gastritis and Gastric Cancer - New Insights in Gastroprotection, Diagnosis and Treatments

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GC risk diagnosis based on the natural history of HP-related chronic gastritisNovel risk markers to identify GC high-risk groups based on a detailed natural history of HP-related chronic gastritis have long been awaited. In this section, we discuss the emerging significance of serum PG as a GC risk marker for more precise identification of GC high-risk groups. Serum PG testHP-related chronic gastritis usually starts in the antrum and expands proximally towards the body of the stomach (Kimura, 1972;Tatsuta et al., 1973). As several studies dealing with endoscopic biopsies or chromoendoscopic testing have found that progression of chronic atrophic gastritis (CAG) increases the risk of cancer (Meister et al., 1979;Sipponen et al., 1985;Siurala et al., 1966;Tatsuta et al., 1993;Testoni et al., 1987), accurate and reliable evaluation of the extent of CAG is considered important for identifying individuals at high risk of cancer. However, accurately diagnosing the extent of CAG based on a few biopsy samples is difficult, because CAG together with intestinal metaplasia is a multifocal process. Furthermore, histological diagnosis of gastric atrophy depends on subjective judgment without a gold standard (Guarner et al., 1999;Plummer et al., 1997). A test for CAG progression that is more convenient, free of discomfort or risk, economical and based on objective parameters is needed. PG is the inactive precursor of pepsin, a digestive enzyme specifically produced in the stomach. Immunologically, two isozymes exist (Kageyama, 2003). PGI is produced by chief cells and mucus neck cells of the gastric fundic glands. In contrast, PGII is produced not only by chief cells and mucus neck cells, but also in cardiac glands, pyloric glands, and Brunner's glands, with localization of producing cells in a wide range from the stomach to the duodenum. The majority of PG produced (about 99%) is secreted in the stomach lumen and functions as a digestive enzyme. However, a small amount of PG (about 1%) is also present in blood and can be evaluated by measuring serum PG levels. Serum PG levels are generally agreed to reflect the morphological and functional status of the stomach mucosa (Hirschowitz, 1957;Samloff et al., 1982). In an endoscopic study with Congo red staining, we have shown a strong correlation between an increase in glandular boundary, associated with diagnosed progression of gastric mucosal atrophy, and stepwise reductions in serum PGI levels and the PGI/PGII ratio ( Fig. 1) (Miki et al., 1987). In other words, by measuring serum PGI and the PGI/II ratio, the progression of CAG, which is involved in GC carcinogenesis, can be objectively evaluated (Ichinose et al., 2001). In addition, during HP infection, serum PGI and PGII increase, and the PG I/II ratio decreases. These findings are improved after eradication treatment (Furuta et al., 1997) and are useful as gastric mucosal inflammatory markers. Several criteria are used in the serum PG test. As criteria for GC screening, the combination of PGI ≤70 ng/ml and PGI/II ratio ≤3.0...

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Studies on Gastritis in the Upper Portion of Stomach by Endoscopic Congo Red Test

Cited by 37 publications

References 2 publications

Early Adenocarcinoma of the Gastric Cardia

Early Adenocarcinoma of the Gastric Cardia

Definition of carcinoma of the gastric cardia

Gastric Cancer Risk Diagnosis and Prevention in Subjects with Helicobacter pylori-related Chronic Gastritis

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