Studies on fused heterocyclic 3,6-disubstituted-1,2,4-triazolo-1,3,4-thiadiazoles: synthesis and biological evaluation

Abstract

In this study, a series of 3,6-disubstituted-1,2, 4-triazolo-[3,4-b]-1,3,4-thiadiazoles (5a-t) were synthesized by condensing 4-amino-3-mercapto-(4H)-1,2,4-triazoles (4a-c) with different aromatic or aroyl acids through one-pot reaction. The compounds were evaluated for their anti-inflammatory, analgesic, ulcerogenic, and lipid peroxidation actions. Some of the newly synthesized compounds showed very good anti-inflammatory activity with low GI toxicity and reduced lipid peroxidation. These compounds also showed interesting profile of analgesic activity in acetic acid-induced writhing test. The findings of the study indicate that the synthesized compounds have superior GI safety profile along with reduction in lipid peroxidation as compared to that of the standard.

Synthesis, Biological Evaluation of 1,3,4-Oxadiazole, Triazole and Uracil Derivatives from Poly (ethylene terephthalate) Waste

“…The 1 H NMR spectrum of 14 revealed D 2 O-exchangable signals at δ 11.9 and 4.3 ppm due to OH and HS protons, in addition to an aromatic multiplet in the region δ 7.69-8. 19. Its mass spectrum showed molecular ion peak m/z 249 (100%).…”

“…Initially, target compounds were evaluated in vitro for their antibacterial and antifungal activity, by inhibition zone technique using two fungi: A. fumigatus (RCMB 02568, Af), Candida albicans (RCMB 05036,Ca), two Gram positive bacteria: S. pneumonia (RCMB 010010,Sp) and B. subtilis (RCMB 010069,Bs), two Gram-negative bacteria: E. coli (RCMB 010052,Ec) and Neisseria gonrrhoeae ( NCCP11945, Ng ) (19)(20)(21) . The results were depicted in Table 1.…”

Design, Synthesis, Anti-Inflammatory And Analgesic Studies Of Novel 1,3,4- Oxadiazole-Thione Derivatives

“…Quinolines are an important class of compounds having various biological activities, such as antimalarial, antitumor, anti-inflammatory [2] and antiparasitic [3][4][5][6][7] etc. Substituted 1,3,4-oxadiazole derivatives also have broad spectrum of biological activities specially analgesic and anti-inflammatory activity [8][9][10]. It is a very weak base due to the inductive effect of the extra heteroatom.…”

Sun degradation and synthesis of new antimicrobial and antioxidant utilising poly (ethylene terephthalate) waste

“…Recently, 1,3,4-oxadiazoles, and pyrazole have attracted special attention due to their anti-inflammatory, (Chenot, 2007;Soural et al, 2006;Kawamura et al, 2002;Krzysztof et al, 2003;Fahim et al, 2017) analgesic, ulcerogenic and lipid per-oxidation activities. Because of our interest in the synthesis of new 1,3,4-oxadiazoles, 1,2,4-triazoles, and pyrazole derivatives of biological interest (Zhuang et al, 2006;Dawood et al, 2005;Dawood and Farag, 1998;Yakout et al, 1999;Husain and Naseer, 2011) we decided to synthesise the title compounds from plastic waste for the future evaluation of their antimicrobial and antioxidant properties.…”