Studies on Experimental Infection of Weanling Mice with Reoviruses.

Hobbs, Thomas R.; Mascoli, Carmine C.

doi:10.3181/00379727-118-29989

Cited by 5 publications

(1 citation statement)

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“…In addition some eoronavirus strains could be propagated only in organ cultures of respiratory epithelium (12,15,16). Although natural reovirns infection as well as mengovirus and MHV infections of mice occur primarily as enteric infections (2), experimental studies have shown that reoviruses can induce a respiratory infection in mice via the intranasal route of administration (8). Similarly, studies of mengovirus infection in mice indicated that this virus can replicate in the lungs after aerosol exposure (1,14) or intraperitoneal inoculation (3) and in the throat after administration of virus by the peroral route (6).…”

Section: Discussionmentioning

confidence: 99%

Growth of mouse hepatitis and other indigenous mouse viruses in tracheal organ cultures

Maase

Veen

1974

Archiv f Virusforschung

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SummaryOrgan cultures of mouse trachea were infected with some indigenous mouse viruses. Mengovirus and reovirus type 3 grew to high titer; inocula of, respectively, 102 and 10 a TCID50 were required to initiate infection. Organ cultures supported also the growth of mouse hepatitis viruses, MI-IV-3 and MHV-S, though to a lesser extent. Viral production was noted for periods of as long as two weeks. None of the viruses had a noticeable effect on the ciliary activity or acquired such capacity on serial passage in organ cultures.

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