Mucosal Immunity to Reovirus Infection

Major, Amy S.; Rubin, Donald H.; Cuff, Christopher F.

doi:10.1007/978-3-642-72095-6_9

Cited by 12 publications

(15 citation statements)

References 54 publications

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“…Because it is the first line of defense against sexually transmitted diseases (STDs), the immune system of the female reproductive tract has attracted increasing scientific study (1). Components of the humoral and cellular immune system are present throughout the female genital tract, which is both an inductive and an effector site for immune responses (2).…”

Section: Introductionmentioning

confidence: 99%

The Number and Distribution of Immune Cells in the Cervicovaginal Mucosa Remain Constant throughout the Menstrual Cycle of Rhesus Macaques

Lü

Torten

et al. 2001

Clinical Immunology

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Section: Introductionmentioning

confidence: 99%

The Number and Distribution of Immune Cells in the Cervicovaginal Mucosa Remain Constant throughout the Menstrual Cycle of Rhesus Macaques

Lü

Torten

et al. 2001

Clinical Immunology

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“…Gastrointestinal infection with type 1 reovirus in mice is a well-established model for mucosal immunity to enteric viruses [22,23] and leads to the generation of specific precursor CTL and IEL compartment and secondary lymphoid organs [23][24][25][26]. These TCR § g CTL lyse virusinfected cells in an MHC-restricted manner following secondary restimulation in vitro [22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Lineage-specific differences among CD8+ T cells in their dependence of NF-κB/Rel signaling

Mora¹,

Chen²,

Boothby³

et al. 1999

Eur. J. Immunol.

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Whereas most CD8 + T cells in lymph nodes and spleen express the CD8 § g heterodimer and depend absolutely on thymic competence for their development, a substantial population of T cells expressing CD8 § § matures extrathymically. Although the existence of these CD8 sublineages is well established, relatively little is known about differences that might exist among CD8 cells in their requirement for particular transcriptional pathways during the development and maintenance of normal populations. Transgenic mice whose T lineage expresses an I O B § mutant exhibited decreased NF-O B signaling and a diminution in mature CD8 T cells. We now have determined that although TCR-dependent CD69 induction by CD8 § § and CD8 § g T cells was unaffected by inhibition of NF-O B, TCR § g CD8 § g T cells were preferentially reduced compared to their TCR § g CD8 § § or TCR + ˇ counterparts. This finding was most prominent in spleen, but was also apparent in Peyer's patches of trans-genic mice. In addition, diminished antiviral cytotoxic responses of CD8 § g intraepithelial lymphocytes were observed after enteric reovirus infection. Taken together, these results indicate that NF-O B signaling is more important for the thymus-dependent TCR § g CD8 § g population than for other CD8 lineages, and thus regulates the number, function, and normal balance of CD8 subsets in the periphery.

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“…Reovirus is a nonenveloped double-stranded RNA-containing virus that has been used to study mucosal immune responses following both oral and respiratory infections (10,27,29,56,63). A difference in the reovirus-specific serum IgG subclass responses following oral or intradermal reovirus infections, which was genetically linked to the H-2 d haplotype, was previously reported (27).…”

mentioning

confidence: 98%

Role of Interleukin-4 (IL-4) and IL-10 in Serum Immunoglobulin G Antibody Responses following Mucosal or Systemic Reovirus Infection

Mathers

Cuff

2004

J Virol

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Mucosal and parenteral immunizations elicit qualitatively distinct immune responses, and there is evidence that mucosal immunization can skew the balance of T helper 1 and T helper 2 responses. However, a clear picture of the effect of the route of infection on the balance of the T helper responses has not yet emerged. Our laboratory previously demonstrated that oral reovirus infection elicits specific serum immunoglobulin G2a (IgG2a), while parenteral reovirus infection elicits the mixed production of specific serum IgG2a and IgG1 in mice of the H-2 d haplotype. Knowing that IgG2a production is indicative of a T helper 1 response and IgG1 production is indicative of a T helper 2 response, we hypothesized that the route of infection influences the development of T helper 1 and T helper 2 responses. Using quantitative reverse transcription-PCR, we found that mRNA for the T helper 1 cytokines gamma interferon and interleukin-12 (IL-12) were expressed in draining lymphoid tissues following both oral and parenteral infections. However, we observed that mRNA for the T helper 2 cytokine IL-10 was suppressed in the Peyer's patches and mesenteric lymph nodes and IL-4 mRNA was suppressed in the mesenteric lymph nodes compared to noninfected controls, following oral infection. Using recombinant cytokines and cytokine knockout mice, we confirmed that IL-4 plays a major role in mediating the route-of-infection-dependent differences in serum IgG subclass responses. Therefore, the route of infection needs to be taken into consideration when developing vaccines and adjuvant therapies.

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Mucosal Immunity to Reovirus Infection

Cited by 12 publications

References 54 publications

The Number and Distribution of Immune Cells in the Cervicovaginal Mucosa Remain Constant throughout the Menstrual Cycle of Rhesus Macaques

The Number and Distribution of Immune Cells in the Cervicovaginal Mucosa Remain Constant throughout the Menstrual Cycle of Rhesus Macaques

Lineage-specific differences among CD8+ T cells in their dependence of NF-κB/Rel signaling

Role of Interleukin-4 (IL-4) and IL-10 in Serum Immunoglobulin G Antibody Responses following Mucosal or Systemic Reovirus Infection

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