Studies on Experimental Hypertension

Goldblatt, Harry

doi:10.1001/archsurg.1941.01210150003001

Cited by 26 publications

(11 citation statements)

References 34 publications

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“…strain (2-3 weeks old) weighing 30-35 g and adult male rats (5-6 weeks old) weighing between 130-140 g were used. They were made hypertensive by bilateral clamping of the renal arteries with silver clips (Goldblatt, Lynch, Hanzal & Summerville, 1934). Chemical sympathectomy was performed before the induction of hypertension in both groups of rats using 6-OHDA.…”

Section: Methodsmentioning

confidence: 99%

Importance of the sympathetic nervous system in the development of renal hypertension in the rat

Grewal¹,

Kaul²

1971

British J Pharmacology

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Summary1. Chemical sympathectomy with 6-hydroxydopamine (6-OHDA) prevented the development of renal hypertension in 80% of weanling male rats of the C.F. strain. 2. Adult male rats treated with 6-OHDA developed hypertension on bilateral clamping of the renal arteries. 3. Demedullation of the adrenal glands followed by 6-OHDA treatment in adult rats prevented the development of hypertension in 75% of them. 4. Weanling rats treated with 6-OHDA did not have any measurable catecholamines in their hearts up to 72-78 days after treatment. 5. Unlike the weanling rats, the hearts of adult rats (demedullated or with intact medulla) showed significant refilling (40-50%) of catecholamine stores 60 days after 6-OHDA treatment. 6. It is concluded that the functional sympathetic nervous system is important in the development of renal hypertension in the rat.

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Section: Methodsmentioning

confidence: 99%

Importance of the sympathetic nervous system in the development of renal hypertension in the rat

Grewal¹,

Kaul²

1971

British J Pharmacology

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“…Renal hypertensive rats were prepared by the method of Goldblatt, Lynch, Hanzal & Summerville (1934). Rats having a stable systolic blood pressure of about 180 mmHg were used.…”

Section: Methodsmentioning

confidence: 99%

Mechanism of the antagonism of the hypotensive action of guanethidine by propranolol

Grewal¹,

Kaul²

1970

British J Pharmacology

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Summary1. Propranolol antagonizes the hypotensive effect of guanethidine in renal hypertensive but not in adrenal demedullated renal hypertensive rats. 2. Guanethidine does not interfere with the release of catecholamines from the adrenal gland which follows splanchnic nerve stimulation in cats anaesthetized with pentobarbitone. 3. Guanethidine does not release or interfere with the release of catecholamines after the intravenous injection of physostigmine in the rat. 4. Propranolol antagonizes the antihypertensive effect of guanethidine by potentiating the vasopressor effects of catecholamines released from the adrenal glands during the induction stage of ether anaesthesia.

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“…Goldblatt demonstraram que a redução da perfusão renal pode produzir uma elevação sustentada da pressão arterial, posteriormente associada ao sistema renina-angiotensinaaldosterona 11,12 . A aldosterona desempenha um papel importante na patogênese da hipertensão e do remodelamento vascular, da hipertrofia ventricular esquerda e das nefropatias, especialmente as que cursam com proteinúria e glomeruloesclerose em indivíduos hipertensos 13. Em fase avançada de falência renal, os valores de aldosterona aumentam significativamente com o decréscimo da filtração glomerular, devido à ativação do sistema renina-angiotensina-aldosterona, secundário à alteração da hemodinâmica glomerular.…”

Section: Introductionunclassified

Análise morfológica do rim e coração de pacientes hipertensos autopsiados

Abrahão

Massa²,

Silva

et al. 2017

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Este estudo tem como objetivo analisar a correlação entre a fibrose renal e cardíaca em indivíduos hipertensos autopsiados, associando-aa dados clínicos e morfológicos. Trata-se de uma pesquisa quantitativa, em que foram utilizados dados clínicos dos laudos de autópsias, provindos da Universidade Federal do Triângulo Mineiro (UFTM), de pacientes hipertensos, além de fragmentos de coração e rim desses pacientes. Laboratorialmente, foram verificados os níveis de ureia e de creatinina desses pacientes, comparados às alterações morfológicas analisadas (fibrose cardíaca e renal). Após a coleta dos materiais, houve a confecção de lâminas e coloração, análise microscópica, morfométrica, e depois estatística. Nesse estudo, não foi comprovada a correlação entre fibrose cardíaca e renal. Pode-se dizer que possivelmente as alterações nos órgãos alvo da hipertensão arterial sistêmica ocorreram em momentos e proporções diferentes entre os indivíduos. This study aims to analyze the correlation between renal and cardiac fibrosis in autopsied hypertensive individuals, associating it with clinical and morphological data. This is a quantitative research, using clinical data from autopsy reports of hypertensive patients from the Federal University of Triângulo Mineiro, Uberaba/MG/Brazil, as well as fragments from these patients' heart and kidney. A comparison of the urea and creatinine levels, considering the analyzed morphological changes (cardiac and renal fibrosis), was conducted through a laboratory analysis. After collecting the materials, the microscope plates were prepared and colored, and microscope and morphometric analysis were conducted, followed by statistical ones. In this study, no proof was found of a correlation between cardiac and renal fibrosis. The changes in the organs targeted by systemic arterial hypertension may have happened in moments and proportions that varied among individuals. Descriptors: Hypertension; Heart; Kidney; Fibrosis; Stroke.Este estudio tiene como objetivo analizar la correlación entre la fibrosis renal y cardíaca en individuos hipertensos autopsiados, asociándola a datos clínicos y morfológicos. Se trata de una investigación cuantitativa, en que fueron utilizados datos clínicos de los informes de autopsias, provenientes de la Universidad Federal do Triângulo Mineiro (UFTM), Uberaba/MG/Brasil, de pacientes hipertensos, además de fragmentos del corazón y riñón de estos pacientes. Laboratorialmente, fueron verificados los niveles de urea y de creatinina de estos pacientes, comparados a las alteraciones morfológicas analizadas (fibrosis cardíaca y renal). Después de la recolección de los materiales, se procedió a la confección de láminas y coloración, análisis microscópico, morfométrico, y después estadístico. En este estudio no fue comprobada la correlación entre fibrosis cardíaca y renal. Se puede decir que posiblemente las alteraciones en los órganos-objetivo de la hipertensión arterial sistémica ocurrieron en momentos y proporciones diferentes entre los individuos.

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Studies on Experimental Hypertension

Cited by 26 publications

References 34 publications

Importance of the sympathetic nervous system in the development of renal hypertension in the rat

Importance of the sympathetic nervous system in the development of renal hypertension in the rat

Mechanism of the antagonism of the hypotensive action of guanethidine by propranolol

Análise morfológica do rim e coração de pacientes hipertensos autopsiados

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