Studies on coagulation, fibrinolysis, kallikrein-kinin and complement activation in systemic and pulmonary circulation during hip arthroplasty with acrylic cement

Biomarkers of Coagulation and Fibrinolysis during Cemented Total Hip Arthroplasty with Pre- versus Postoperative Start of Thromboprophylaxis

“…Earlier studies have demonstrated a more moderate expression of the level of biomarkers in peripheral venous blood compared to arterial blood or mixed venous blood, which may be due to passage of the arteriovenous filter or dilution [25]. Furthermore, several biomarkers are available to analyze coagulation and fibrinolysis and they reflect activity from different parts of these processes.…”

Erratum

“…Such endothelial derangement may cause nidi for thrombus formation and partly explain the high incidence of proximal DVT following this kind of surgery (Stamatakis et al 1977, Nillius andNylander 1979). In addition, blood-borne procoagulant cellular debris from the femoral bone marrow will be sequestered in the pulmonary microcirculation and induce substantial local and systemic hypercoagulation (Dahl et al 1988(Dahl et al , 1993(Dahl et al , 1995 which may contribute to both intraoperative cardiorespiratory and vascular dysfunction and postoperative DVT.…”

Thromboprophylaxis in hip arthroplasty: New frontiers and future strategy

“…Thrombin generation caused by bone traumatization is significantly more severe in arterial than in venous blood during hip replacement surgery (Dahl et al 1988, 1992, Dahl 1997b. This is reflected by a high rate of coagulation-related deaths after major orthopedic surgery (Schoning et al 1980, Dahl 1997a.…”

“…Damage to the vessel wall draining the operation area, enhanced local and systemic activation of coagulation and stagnation of the blood flow during surgery trigger intraoperative and postoperative thromboembolic events (Stewart et al 1983, Dahl et al 1988, 1992, McNally and Molland 1993. Postoperatively, suppression of the fibrinolytic system followed by reactivation of the coagulation system and concomitantly reduced blood flow in the lower limbs favor thrombosis formation for at least 5 weeks Molland 1993, Dahl et al 1995).…”