Studies on chemical induction of chromosomal aberrations in postcopulation germ cells and zygotes of female mice. II. Induction of heritable translocations.

Abstract

The induction of heritable translocations with chemicals in postcopulation germ cells of female mice was investigated.In the methyl methanesulfonate (MMS) -treated group (100 mg/kg), 14 partially sterile and 5 sterile males out of 118 Fr male progeny were found. In contrast, in the mitomycin C (MC) -treated group (3 mg/kg and 4 mg/kg) the frequencies were low. These results indicate that the yield of heritable translocations parallels the formation of chromosome-type aberrations at the first cleavage reported previously.