Studies on changes of ligandin and glutathiqne S-transferase durihg 3'-methyl-4-dimethylaminoazobenzene hepatocarcinogenesis

Gene deletion and partial deficiency of the glutathione S‐transferase (ligandin) system in man

“…These results also have significance in the evaluation of ligandinaemia associated with liver disease [4][5][6][7][8][9]. The presence of a common null allele which significantly affects the level of glutathione S-transferase/ligandin in liver is likely to influence the degree of ligandinaemia which occurs in various hepatic disorders.…”

“…That study suggested that relative deficiency of these acceptor proteins may be rate limiting in a transfer process. More recently, ligandinaemia has been reported in a number of inflammatory and neoplastic liver diseases, including viral and chronic hepatitis, cirrhosis and primary hepatocarcinoma [4][5][6][7]. These observations have prompted the suggestion that ligandinaemia may well provide a further means of evaluating liver damage and be of diagnostic value in cases of primary liver cell cancer [8,9].…”