Studies on batch formulation of a kit for the preparation of the 99m Tc-Ubiquicidin (29-41): An infection imaging agent

Arjun, Chanda; Mukherjee, Archana; Bhatt, Jyotsna; Chaudhari, Pradip; Repaka, Krishna Mohan; Venkatesh, Meera; Samuel, Grace

doi:10.1016/j.apradiso.2015.09.009

Cited by 12 publications

(4 citation statements)

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“…Labeling of peptides with 99m Tc was carried out at room temperature, pH ∼10 using direct labeling method. 21 Both 99m Tc-UBI (29-41) and 99m Tc-UBI (29-41)-2-APBA complexes were formed with high (>96%) radiochemical purity (RCP). Retention time (R t ) were also comparable for these complexes i.e., 14.89 ± 0.12 min (n = 3) for 99m Tc-UBI (29-41) and 15.04 ± 0.07 min (n = 3) for 99m Tc-UBI (29-41)-2-APBA complex.…”

Section: Radiolabeling and In Vitro Stability Studiesmentioning

confidence: 99%

Integrating a covalent probe with ubiquicidin fragment enables effective bacterial infection imaging

et al. 2022

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Section: Radiolabeling and In Vitro Stability Studiesmentioning

confidence: 99%

Integrating a covalent probe with ubiquicidin fragment enables effective bacterial infection imaging

et al. 2022

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“…A pooled meta-analysis of clinical studies with 99m Tc-UBI 29-41 showed 95% sensitivity, 93% specificity and 94% accuracy in various clinical settings including prosthetic infections, diabetic foot infections, fever of unknown origin, osteomyelitis, mediastinitis, and appendicitis [55,64,65]. Due to its ability to discriminate between infection and sterile inflammation, general safety, the lack of side effects [66][67][68][69], and the successful transformation to kit formulations [59,[70][71][72], radiolabelled UBI 29-41 has been proposed as a good candidate for applications in routine imaging [4,9,61]. Nevertheless, prospective multi-centre studies of both 99m Tc-and 68 Ga-UBI 29-41 should still be carried out to achieve robust evidence of the accuracy in clinical imaging of bacterial infections.…”

Section: Imaging Of Infections With Antimicrobial Peptidesmentioning

confidence: 99%

An update on radiotracer development for molecular imaging of bacterial infections

Welling

Hensbergen

Bunschoten

et al. 2019

Clin Transl Imaging

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Background Bacterial infections are still a major global healthcare problem. To combat the increasing antimicrobial resistance, early diagnosis of bacterial infections-including the identification of bacterial species-is needed to improve antibiotic stewardship and to help reduce the use of broad-spectrum antibiotics. To aid successful targeted antibiotic treatment, specific detection and localisation of infectious organisms is warranted. Nuclear medicine imaging approaches have been successfully used to diagnose bacterial infections and to differentiate between pathogen induced infections and sterile inflammatory processes. Aim In this comprehensive review we present an overview of recent developments in radiolabelled bacterial imaging tracers. Methods The PubMed/MEDLINE and Embase (OvidSP) literature databases were systematically searched for publications on SPECT and PET on specific imaging of bacterial using specific guidelines with MeSH-terms, truncations, and completion using cross-references. Tracers in literature that was extensively reviewed before 2016 were not included in this update. Where possible, the chemical structure of the radiolabelled compounds and clinical images were shown. Results In 219 original articles pre-clinical and clinical imaging of bacterial infection with new tracers were included. In our view, the highest translational potential lies with tracers that are specific to target the pathogens: e.g., 99m Tc-and 68 Galabelled UBI 29-41 , 99m Tc-vancomycin, m-[ 18 F]-fluoro-PABA, [methyl-11 C]-D-methionine, [ 18 F]-FDS, [ 18 F]-maltohexaose and [ 18 F]-maltotriose. An encouraging note is that some of these tracers have already been successfully evaluated in clinical settings. Conclusion This review summarises updates in tracer development for specific (pre-clinical and clinical) imaging of bacterial infections. We propsed some promising tracers that are likely to become innovative standards in the clinical setting in the near feature.

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“…Sintesa nano koloid HSA SnCl2.2H2O dilarutkan dengan HCl dan diencerkan dengan aquabides yang sudah dijenuhkan dengan gas nitrogen. 9,18,19 Larutan SnCl2.2H2O ditambahkan ke dalam larutan asam askorbat dan glukosa dalam akuabides. Larutan albumin dan larutan dapar fosfat ditambahkan ke dalam larutan tersebut dan dijenuhkan dengan gas nitrogen selama 15 menit.…”

Section: Metode Alat Dan Bahanunclassified

“…Larutan albumin dan larutan dapar fosfat ditambahkan ke dalam larutan tersebut dan dijenuhkan dengan gas nitrogen selama 15 menit. pH larutan diatur dengan menambahkan larutan NaOH 0,1 N (9,18). Larutan dipanaskan di dalam penangas air sambil di aduk dengan batang pengaduk selama waktu tertentu (sesuai dengan desain percobaan).…”

Section: Metode Alat Dan Bahanunclassified

Optimasi Sintesa Nanokoloid Human Serum Albumin sebagai Agen Limfoskintigrafi Menggunakan Central Composite Design-Response Surface Methodology

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Setiyowati²,

Triningsih³

et al. 2022

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Studies on batch formulation of a kit for the preparation of the 99m Tc-Ubiquicidin (29-41): An infection imaging agent

Cited by 12 publications

References 12 publications

Integrating a covalent probe with ubiquicidin fragment enables effective bacterial infection imaging

Integrating a covalent probe with ubiquicidin fragment enables effective bacterial infection imaging

An update on radiotracer development for molecular imaging of bacterial infections

Optimasi Sintesa Nanokoloid Human Serum Albumin sebagai Agen Limfoskintigrafi Menggunakan Central Composite Design-Response Surface Methodology

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