Studies on Antiulcer Agents. I. The Effects of Various Methanol and Aqueous Extracts of Crude Drugs on Antiulcer Activity

Muto, Yoshiaki; Ichikawa, Hiromi; Kitagawa, Osamu; Kumagai, Kazuhiro; Watanabe, Masafumi; Ogawa, Etsuo; Seiki, Masao; Shirataki, Yoshiaki; Yokoe, Ichiro; Komatsu, Manki

doi:10.1248/yakushi1947.114.12_980

Cited by 18 publications

(5 citation statements)

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“…Iridal-type triterpenoids are characteristic constituents of plants in the genera Iris and Belamcanda. Iridal compounds have been reported to exhibit antiulcer activity 14 and piscicidal activity. 15 The present results suggest that other congeners of 1 may be potential mouse skintumor promoters.…”

Section: Resultsmentioning

confidence: 99%

28-Deacetylbelamcandal, a Tumor-Promoting Triterpenoid from Iris tectorum

et al. 1999

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A spiroiridal-type triterpenoid, 28-deacetylbelamcandal (1), was isolated from the rhizomes of Iris tectorum as an active principle that stimulated differentiation of human promyelocytic leukemia (HL-60) cells, a short-term screening method for 12-O-tetradecanoylphorbol 13-acetate (TPA)-type tumor promoters. In the same manner as TPA, compound 1 bound to protein kinase C (PKC) and activated PKC, and induced tumor necrosis factor-alpha release from HL-60 cells. In an in vivo study, groups treated with 100 microg 7, 12-dimethylbenz[a]anthracene plus 400 nmol of 1 showed 64.3% tumor incidence by week 20. It has thus been demonstrated that 1 represents a new structural class of mouse skin-tumor promoters.

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Section: Resultsmentioning

confidence: 99%

28-Deacetylbelamcandal, a Tumor-Promoting Triterpenoid from Iris tectorum

et al. 1999

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“…Naturally occurring ichthyotoxic substances also often exhibit a variety of biological properties such as insecticide, tumor-promoting, antitumor and antifungal activities, and/or inhibitory effect on activation of Epstein−Barr virus early antigen induced by TPA, etc. − In a recent study of Iris germanica L. (Iridaceae), we reported the characterization of several iridal-type triterpenoids including new iridals, irisgermanicals A, B, and C, as ichthyotoxic components. These active compounds included α-irigermanal, iriflorental, and iripallidal, which were previously demonstrated to have a potent in vivo antiulcerogenic effect on indomethacin- or stress-induced ulceration in rats . These findings prompted further investigation of the iridaceous species Belamcanda chinensis (L.) DC, as part of a research program aimed at finding novel biologically active natural products using an ichthyotoxic assay as a primary indicator.…”

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confidence: 99%

“…These active compounds included R-irigermanal, iriflorental, and iripallidal, which were previously demonstrated to have a potent in vivo antiulcerogenic effect on indomethacin-or stress-induced ulceration in rats. 6 These findings prompted further investigation of the iridaceous species Belamcanda chinensis (L.) DC, as part of a research program aimed at finding novel biologically active natural products using an ichthyotoxic assay as a primary indicator. The dried rhizomes of B. chinensis have been used as a traditional Chinese medicine for disorders of the throat including coughing and pharyngitis.…”

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confidence: 99%

Iridal-Type Triterpenoids with Ichthyotoxic Activity from Belamcanda chinensis

et al. 1998

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Ichthyotoxic activity-guided fractionation of the hexane and ether extracts of Belamcanda chinensis (Iridaceae) has resulted in the isolation of eleven iridal-type triterpenoids including six new compounds, 3-O-tetradecanoyl-16-O-acetylisoiridogermanal (4), 3-O-decanoyl-16-O-acetylisoiridogermanal (5), belachinal (7), anhydrobelachinal (9), epianhydrobelachinal (10), and isoanhydrobelachinal (11). Structures of the new iridals were determined by spectral and chemical methods. The absolute configuration of isoiridogermanal (1) at C-16 was determined to be R by the modified Mosher's method. Of these compounds, 16-O-acetylisoiridogermanal (3), 7, and spiroiridal (12) exhibited potent ichthyotoxic activity against killie-fish (Oryzias latipes).

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“…Most of its species have reported as anticancer, antiulcer, cytotoxic, insecticidal and piscicidal activities [2,5,6,7,8,9,11,12,13]. In Anatolian folk medicine, rhizomes of I. germanica and I. pseudacarius are applied to treat constipation and stomachache [14].…”

Section: Introductionmentioning

confidence: 99%