Studies on antioxidant enzymes in mice exposed to pulsed electromagnetic fields

Eraslan, Gökhan; Bilgili, Ali; Akdoğan, Mehmet; Yarsan, Ender; Eşsiz, Dinç; Altıntaş, Levent

doi:10.1016/j.ecoenv.2006.01.001

Cited by 15 publications

(9 citation statements)

References 16 publications

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“…The antiinflammatory effects of diclofenac were mediated through inhibition of COX thereby suppressing even the physiological levels of PGE 2, which afforded mucosal protection (Wallace et al, 2000). The normal animals exposed to PEMF did not show any changes in studied parameters as reported earlier (Eraslan et al, 2007). The biological systems in transition state were more sensitive to PEMF exposures than stationary systems (Ubeda et al, 1997).…”

Section: Discussionmentioning

confidence: 80%

Low frequency and low intensity pulsed electromagnetic field exerts its antiinflammatory effect through restoration of plasma membrane calcium ATPase activity

Selvam¹,

Ganesan

Raju³

et al. 2007

Life Sciences

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Section: Discussionmentioning

confidence: 80%

Low frequency and low intensity pulsed electromagnetic field exerts its antiinflammatory effect through restoration of plasma membrane calcium ATPase activity

Selvam¹,

Ganesan

Raju³

et al. 2007

Life Sciences

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“…The same authors also recorded an inhibitory effect of EMF exposure on alkaline phosphatase, phosphoglycerate kinase and adenylate 2008 [11] showed that upon exposure to ELF-EMFs the specific activity of Cu 2+ , Zn 2+ Superoxide Dismutase (SOD1) drops significantly, while the free radicals generation ability of a Fe 2+ Xanthine Oxidase (XO) increases, both in manner related to the enzyme exposure-time and EMFfrequency. The reported ELF-EMFs ability to produce free radicals [27] and to modify the oxidative status of the cell could thereby be not a direct one, but indirect, by simply activating the ROS generating enzymes and decreasing the activity of the anti-oxidant enzymes.…”

Section: Discussionmentioning

confidence: 99%

“…A possible mechanism of ELF-EMs action reported in the literature is by directly generating free-radicals [27], which could serve as substrates for HRP or could catalyse the non-enzymatic oxidation of o-dianisidine. The fact that in our experiments both the non-enzymatic controls and the controls lacking H 2 O 2 were negligible indicates that it is not the case, at least for ELF-EMFs exposure times of up to 5 min.…”

Section: Discussionmentioning

confidence: 99%

“…Indirect evidence that this might be the case exist, as HRP is one of the main cellular defence systems against different reactive oxygen species (ROS) and the literature pool is rich in reports indicating that ELF-EMF exposure induces oxidative damage in living cells [2,11,25,26]. Are these changes the direct effect of the ELF-EMFs ability to produce free-radicals [27]? Or, are the EMFs interacting with the key players of the anti-oxidant cellular systems, the metal-containing enzymes superoxide-dismutase, peroxidase and catalase?…”

Section: Introductionmentioning

confidence: 99%

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ELF-EMF exposure decreases the peroxidase catalytic efficiency in vitro

2016

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The activity of purified Fe3+ containing horseradish peroxidase (HRP) was recorded while the enzyme was exposed to two low frequency pulsed electromagnetic fields (ELF-EMFs) with different frequencies: 50 Hz/2.7 mT and 100 Hz/5.5 mT. No statistically significant difference in the Michaelis constant (Km) values between the control enzyme and the enzyme exposed to any of the two ELF-EMF used could be detected (53 ± 11 μM vs 67 ± 10 μM vs 42 ± 11 μM respectively), indicating that upon short exposure times, there are no large structural alterations of the enzyme that affect the substrate affinity. A 50 Hz/2.7 mT EMF did however, cause a significant decrease in the maximum rate (Vmax) value (from 3.31 ± 0.17 μmoles/min to 1.6 ± 0.19 μmoles/min, p<0.03) and a drop of the catalytic efficiency to less than half (from 0.66 ± 0.03 s-1 to 0.32 ± 0.04 s-1, p<0.05). These observations are the first experimental proofs that support the previously postulated mechanism of coupling between ELF-EMF and living systems based on a resonant frequency specific for a given ion molecule.

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“…Foram analisados os efeitos dos CEMP por 8 horas, 2 mT e 50 Hz em ratos, detectando-se, com essas doses, danos oxidativos. Deve-se considerar o peso do animal ao ser comparado ao adulto humano; portanto, os achados deste estudo podem ser questionados38 . Portanto, a literatura, de maneira geral, apresenta informações incompletas sobre os parâmetros de utilização da magnetoterapia (Quadro 1).…”

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Magnetoterapia: é possível este recurso fazer parte da rotina do fisioterapeuta brasileiro?

Meyer

Cavalcanti

Silva

et al. 2011

Arq. Bras. Ciên. Saúde

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O uso de campos eletromagnéticos pulsados (CEMP) é uma das terapias frequentemente utilizadas pelo fisioterapeuta para tratamento de seus pacientes com diferentes patologias e em diversos países, exceto no Brasil. Devido ao longo tempo de utilização em todos os continentes e a quantidade de publicações existentes sobre o tema, busca-se compreender o motivo de essa técnica não estar presente na rotina de tratamento das clínicas de fisioterapia brasileiras. Para tentar responder a essa questão, realizou-se uma revisão sistemática na base de dados do Pubmed, de 1968 a 2010 (42 anos), com as palavras-chave “PEMF” e “Pulsed Electromagnetic Fields”, encontrando-se, respectivamente, 274 e 899 resultados. Após esse levantamento, foram selecionados 36 artigos do período de 1981 a 2008 hand made, além de consulta a 6 livros. Após a coleta de dados, perceberamse resultados positivos no tecido ósseo, em relação à consolidação de fraturas e a osteoporose, devido à sua ação piezoelétrica. Os efeitos antiinflamatórios e regenerativos também são citados. Portanto, o conhecimento desse recurso no Brasil deve ser despertado em todos os profissionais de saúde que compõem as equipes multidisciplinares de assistência, para que o tratamento possa fazer parte da rotina de trabalho dos fisioterapeutas, beneficiando pacientes de todas as faixas etárias e portadores de diferentes problemas. Sugere-se a fabricação de aparelhos geradores de PEMF por empresas nacionais para diminuir custos e facilitar o acesso a esse agente físico.

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Studies on antioxidant enzymes in mice exposed to pulsed electromagnetic fields

Cited by 15 publications

References 16 publications

Low frequency and low intensity pulsed electromagnetic field exerts its antiinflammatory effect through restoration of plasma membrane calcium ATPase activity

Low frequency and low intensity pulsed electromagnetic field exerts its antiinflammatory effect through restoration of plasma membrane calcium ATPase activity

ELF-EMF exposure decreases the peroxidase catalytic efficiency in vitro

Magnetoterapia: é possível este recurso fazer parte da rotina do fisioterapeuta brasileiro?

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