Studies on antidermatophytic effect of Allamanda cathertica

Nahar, Azizun; Ashrafuzzaman, Syed; Islam, Nazrul; Alam, Md. Shah

doi:10.3329/bjp.v5i1.4610

Cited by 4 publications

(4 citation statements)

References 6 publications

(2 reference statements)

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“…According to the literature and AntiBase database (https://application.wiley-vch.de/stmdata/antibase.php), the molecular formula of this compound was suggested to be C 19 H 12 O 7 , which corresponded to daphnoretin (7-hydroxy-6-methoxy-3-(2-oxochromen7yl-oxychromen-2-one). 1,31 1 H-nuclear magnetic resonance (NMR) and 13 C-NMR spectroscopic data (Supplemental Table S1) confirmed the identification. Even if the quantities were not sufficient to obtain a complete carbon NMR spectrum, the 2-dimensional correlations validated the chemical structure.…”

Section: Resultsmentioning

confidence: 56%

“…Fungal infections of the skin and nails affect millions of people worldwide and require a costly and lengthy treatment. 1 These infections are mainly caused by some highly specialized filamentous fungi, called dermatophytes, exhibiting high affinity for keratinized tissues such as superficial layers of the skin, hair, and nails. 2 Antifungals used against dermatophytes exhibit several side effects (digestive or skin disorders) and have limited efficacy.…”

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confidence: 99%

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Antifungal and Antiaging Evaluation of Aerial Part Extracts ofThymelaea hirsuta(L.) Endl

Amari

Razafimandimby²,

Auberon

et al. 2021

Natural Product Communications

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In western Algeria, Thymelaea hirsuta aerial parts are traditionally used topically for the treatment of human skin infections. For a better knowledge of its biological activities, this study aimed at evaluating the in vitro antifungal activity and antiaging properties of several extracts of the aerial parts by in vitro assays. Antifungal activity was investigated by using the reference microbroth dilution method (National Committee for Clinical Laboratory Standards) against the dermatophytes ( Microsporum audouinii, Nannizzia gypsea, Trichophyton interdigitale, and Trichophyton rubrum) and the yeast ( Candida albicans). Antiaging (inhibition of 1,1-diphenyl-2-picrylhyorazyl radical scavenging and tyrosinase, lipoxygenase, elastase, and hyaluronidase activities) assays were performed in 96-well plates. All the extracts of T. hirsuta exhibited antifungal activity against M. audouinii, T. rubrum, and C. albicans, while no activity was found against N. gypsea and T. interdigitale. The highest activity was observed on M. audouinii for the aqueous leaf (minimum inhibitory concentration [MIC] of 8 µg/mL) and stem extracts (MIC = 31 µg/mL) and the methanolic leaf extract (MIC = 8 µg/mL). Additionally, some marked morphological alterations were observed on M. audouinii hyphae with all aqueous extracts. Concerning antiage bioassays, the major activity was found against hyaluronidase for the aqueous and methanolic extracts from leaves and the methanolic extract from flowers. Analysis of this last extract by high-performance liquid chromatography, electrospray ionization-mass spectrometry, and nuclear magnetic resonance, allowed us to identify daphnoretin and daphnetin as major components of this extract, and, therefore, responsible for the antiaging activity. In conclusion, this study provides additional experimental data supporting the traditional use of T. hirsuta extracts on some cutaneous dermatophytosis, as well as new perspectives on the potential use of T. hirsuta to ensure better healing of the skin.

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Section: Resultsmentioning

confidence: 56%

mentioning

confidence: 99%

Antifungal and Antiaging Evaluation of Aerial Part Extracts ofThymelaea hirsuta(L.) Endl

Amari

Razafimandimby²,

Auberon

et al. 2021

Natural Product Communications

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“…The plant is native to Brazil [ 24 ] and its various parts such as leaves, flowers, roots and stems are used in traditional medicine [ 25 ] for the treatment of jaundice [ 26 ], and have various pharmacological activities such as wound healing [ 26 ], antioxidant [ 27 , 28 , 29 , 30 ], antimicrobial [ 30 , 31 , 32 ], antifungal [ 33 ], antimalarial [ 34 ], anti-inflammatory [ 35 ]; anticancer [ 20 , 36 , 37 ] and gastrointestinal effects [ 38 ]. A dichloromethane (CH 2 Cl 2 ) extract of the whole plant tested on two pathogenic dermatophytes, Trichophyton rubrum and Microsporum gypseum , showed moderate activity at a concentration of 50 μg/disk, but very strong activity at a concentration of 200 μg/disk, suggesting that A. cathartica may possess antidermatophyte constituents that could be useful in the treatment of ringworm [ 39 , 40 ].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical and Biological Study of Trophic Interaction between Pseudosphinx Tetrio L. Larvae and Allamanda Cathartica L.

Matignon¹,

Monpierre

et al. 2023

Plants

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In this article, we propose to explore the chemical interaction between Pseudosphinx tetrio L. and Allamanda cathartica L. using different analytical methods, including an innovative electrochemical approach (called electrochemical ecology) and multivariate analysis, and we investigate the potential antimicrobial effects (antibacterial and antifungal activities) of this interaction in order to gain a better understanding of their specific interaction. The analytical study presents a similar chemical profile between the leaves of healthy and herbivorous A. cathartica and the excretions of the caterpillars. The similar analytical profile of the leaves of A. cathartica and the excretions of P. tetrio, and the difference with the caterpillar bodies, suggests a selective excretion of compounds by the caterpillar. The measured antimicrobial activities support the physicochemical tests. The natural products found selectively in the excretions (rather than in the body) could explain the ability of P. tetrio to feed on this toxic Apocynaceae species.

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“…Recently, antidermatophytic studies have been done with the active principles of numerous medicinal plants. Antidermatophytic activity of dichloromethane and methanol extracts of whole plant of Allamanda cathertica was evaluated against two pathogenic dermatophytes Trichophyton rubrum and Microsporum gypseum by Nahar et al (2010) [7]. Adejumo and Bamidele (2009) [8] studied antidermatophytic potential of six medicinal plant extracts against T. rubrum and T. mentagrophytes.…”

Section: Introductionmentioning

confidence: 99%

Antidermatophytic Activity in Crude Extracts of Some Medicinal Plants of Jalpaiguri District

Ray¹,

Sen²,

Paul³

2019

IJEAST

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Thirteen commonly found species of plants reported to be used against skin ailments, were selected for the present study . The aqueous leaf extracts were first screened qualitatively for the presence of nine biochemical components (alkaloids, anthranol glycosides, saponins, phenols, tannins, flavonoids, terpenoids, protein and reducing sugar) and the scores were noted. All the extracts were further tested by agar incorporation method against three common dermatophytes -Trichophyton rubrum, Trichophyton mentagrophytes and Microsporum audouinii. The extracts of Catharanthus roseus and Cassia alata were found to be the most potent followed by Ageratum conyzoides

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Studies on antidermatophytic effect of Allamanda cathertica

Cited by 4 publications

References 6 publications

Antifungal and Antiaging Evaluation of Aerial Part Extracts ofThymelaea hirsuta(L.) Endl

Antifungal and Antiaging Evaluation of Aerial Part Extracts ofThymelaea hirsuta(L.) Endl

Phytochemical and Biological Study of Trophic Interaction between Pseudosphinx Tetrio L. Larvae and Allamanda Cathartica L.

Antidermatophytic Activity in Crude Extracts of Some Medicinal Plants of Jalpaiguri District

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