Studies on anticholinesterase and DPPH radical scavenging effects of 41 species of Fritillaria L. genus of Turkish origin

Sevim, Duygu; Senol, FS; Orhan, Ilkay Erdogan; Sener, B.; Kaya, Erdal; Rastgeldi, Ufuk; Kesici, Ayşe Elitok; Aslay, Meral

doi:10.1055/s-0031-1282922

Cited by 4 publications

(4 citation statements)

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“…Demecolcine, another major alkaloid, has lower toxicity than colchicine and has been successfully used in the treatment of myeloid leukemia and Hodgkin's syndrome. Pharmacological studies have showed that the Colchicum species possess antioxidant [8][9][10], antibacterial [8,9], acetylcholinesterase [11], anti-inflammatory [12], and antiarthritic [13] properties.…”

Section: Introductionmentioning

confidence: 99%

“…Sevim ve ark. [11] investigated the anti-cholinesterase and antioxidant activities of methanolic extracts from bulbs and seeds of C. szovitsii subsp. szovitsii and observed that only the seed extracts were potent against butyrylcholinesterase (BChE) and have displayed antioxidant activity by means of the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay.…”

Section: Introductionmentioning

confidence: 99%

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Chemical Profiling and Biological Properties of Extracts from Different Parts of Colchicum Szovitsii Subsp. Szovitsii

et al. 2019

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Like other members of the Colchicum genus, C. szovitsii subsp. szovitsii is also of medicinal importance in Turkish traditional medicine. However, its biological properties have not been fully investigated. Herein, we focused on the evaluation of the in vitro antioxidant and enzyme inhibitory effects of flower, root and leaf extracts, obtained using different extraction methods. In addition, a comprehensive (poly)-phenolic and alkaloid profiling of the different extracts was undertaken. In this regard, ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS) allowed us to putatively annotate 195 polyphenols and 87 alkaloids. The most abundant polyphenols were flavonoids (83 compounds), whilst colchicine and 2-demethylcolchicine were some of the most widespread alkaloids in each extract analyzed. However, our findings showed that C. szovitsii leaf extracts were a superior source of both total polyphenols and total alkaloids (being, on average 24.00 and 2.50 mg/g, respectively). Overall, methanolic leaf extracts showed the highest (p < 0.05) ferric reducing antioxidant power (FRAP) reducing power (on average 109.52 mgTE/g) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging (on average 90.98 mgTE/g). Interestingly, each C. szovitsii methanolic extract was more active than the water extracts when considering enzymatic inhibition such as against tyrosinase, glucosidase, and acetylcholinesterase (AChE). Strong correlations (p < 0.01) were also observed between polyphenols/alkaloids and the biological activities determined. Multivariate statistics based on supervised orthogonal projections to latent structures discriminant analysis (OPLS-DA) allowed for the detection of those compounds most affected by the different extraction methods. Therefore, this is the first detailed evidence showing that C. szovitsii subsp. szovitsii might provide beneficial effects against oxidative stress and the associated chronic diseases. Nevertheless, the detailed mechanisms of action need to be further investigated.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chemical Profiling and Biological Properties of Extracts from Different Parts of Colchicum Szovitsii Subsp. Szovitsii

et al. 2019

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“…Methanol extracts of the seeds of Colchicum balansae were investigated for their in vitro cholinesterase (AChE and BChE) inhibitory activity at 200 μg/ ml,using ELISA microplate assay. Acetyl cholinesterase inhibitory activity possessed by the methanolic extracts of Colchicum balansae seeds extract (200μg/ml) was10.90 ±1.17% and BChE inhibitory activity was 44.22 ±2.46% (23) .…”

Section: Colchicum Balansaementioning

confidence: 94%

Medicinal plants with cholinesterase inhibitory activity and their applications

Al-Snafi¹

2022

GSC Biol. and Pharm. Sci.

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Cholinesterase catalyzes the hydrolysis of acetylcholine in the synapse, into choline and acetic acid, a reaction necessary to return the cholinergic neuron in the central and peripheral nervous systems, to the resting potential after activation. The cholinesterase enzyme inactivation, or inhibition induced by various inhibitors, leads to accumulation of acetylcholine, and subsequent hyper-stimulation of nicotinic and muscarinic receptors. Hence, acetylcholinesterase inhibitors, are applied as relevant drugs and toxins. The current review highlighted the medicinal plants with cholinesterase inhibitory effects.

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“…Methanol extracts of Colchicum balansae were investigated for antioxidant effect at 2000 μg/ ml by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity. Methanol extracts of Colchicum balansae displayed low effect in DPPH, below 40% [99].The antioxidant properties of Colchicum balansae Planchon (CB) were investigated. The solvent extracts were prepared from CB tubers and leaves.…”

Section: Colchicum Balansaementioning

confidence: 99%

Medicinal plants with antioxidant and free radical scavenging effects (part 2): plant based review

Al-Snafi¹

2016

IOSRPHR

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Previous studies showed that a wide range of medicinal plants exerted antioxidant and free radical scavenging activity. These plants included: Cicer arietinumThe free radicals scavenging, antioxidant properties and intestinal α-glucosidase inhibitory activity of methanol extract of two varieties of Cicer arietinum were evaluated. Compared with raw seeds increase in total polyphenol and flavonoids concentration in green gram sprouts and Kabuli Chana sprouts (KCs) were recorded. Total protein concentrations in sprouts did not differ from non-sprouted grains. 2,2'-Azinobis (3-ethyl benzthiazoline-6-sulphonic acid) cation scavenging activity was more than twice in Bengal gram sprouts of (BGs) and KCs than their raw seeds. 2,2-diphenyl-1-picrylhydrazyl, hydrogen peroxide scavenging, nitro blue tetrazolium reducing and glucose-induced Hb-glycation inhibitory activity did not differ from non-sprouted raw grains. Increase in rat intestinal α-glucosidase inhibitory activity was observed in BGs and KCs. BGs significantly mitigated first 30 min starch-induced postprandial glycemic excursions and reduced 2 h postprandial glycemic load [44][45].The extent of free radical scavenging properties and antioxidant effects of crude extracts of sprouted Cicer arietinum (Chick pea/Chana/Bengal gram) seeds were evaluated. Two main varieties of Cicer arietinum seeds viz. Kabuli-Chana (cream seed-coat) and Bengal gram (brown seed-coat) were examined and compared for their free radical scavenging properties and antioxidant effects. Free radical scavenging properties were evaluated against stable 2, 2-diphenyl-1-picrylhydrazyl radical (DPPH) and hydrogen peroxide radical and the Medicinal plants with antioxidant and free radical scavenging 63 extent of antioxidant effect was assessed by lipid peroxidation induced by ferrous sulphate on the lipid present in the liver homogenate. The results showed that the two Cicer arietinum extracts were differed in their capacities to quench or inhibit DPPH, hydrogen peroxide and lipid peroxide. Brown colored Cicer arietinum sprouts showed the greatest activity against DPPH radicals, hydrogen peroxide radicals and lipid peroxide compared to the cream variety [45][46].The root of Cicer arietinum was extracted using solvents of different polarities and explored for in vitro free radical scavenging activity. Preliminary assays of three different extracts of Cicer arietinum root showed that the extracts possess electron donating ability and reduction of ferric ion to ferrous in a cell free system at pH-7.4. It has also been found from total antioxidant capacity as assessed by reduction of molybdate showed Cicer arietinum root extracts to possess (standard) ascorbic acid equivalents per milligrams of the extracts. Hydroalcoholic root extract was found more effective when compared to alcoholic and water extracts in scavenging 1, 1-diphenyl-2-picrylhydrazyl, reducing ferric ion and molybdate reduction in antioxidant capacity. A significant correlations exist between extract concentrations and percentage scaveng...

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Studies on anticholinesterase and DPPH radical scavenging effects of 41 species of Fritillaria L. genus of Turkish origin

Cited by 4 publications

References 0 publications

Chemical Profiling and Biological Properties of Extracts from Different Parts of Colchicum Szovitsii Subsp. Szovitsii

Chemical Profiling and Biological Properties of Extracts from Different Parts of Colchicum Szovitsii Subsp. Szovitsii

Medicinal plants with cholinesterase inhibitory activity and their applications

Medicinal plants with antioxidant and free radical scavenging effects (part 2): plant based review

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