Studies on anti-inflammatory activity of sulfated polysaccharides from cultivated fungi Antrodia cinnamomea

Cheng, Jing-Jy; Chao, Chi-Hsein; Chang, Pin-Chun; Lu, Mei-Kuang

doi:10.1016/j.foodhyd.2014.09.035

Cited by 76 publications

(26 citation statements)

References 29 publications

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“…It has to be referred that sulfated polysaccharides, DAP and SCP, have not been reported previously. Due to bioactivities related to sulfate content, sulfated polysaccharides play an important role in regulation of the immune system, for example, stimulating immune cell proliferation and production of immune-related molecules [25,26], which might inspire more concerns in food and pharmaceutical industries. Additionally, the absorption bands between 1040 and 1020 cm −1 were attributed to the characteristic C–O–C glycosidic bond vibrations and ring vibrations, overlapped with stretching vibrations of side group C–O–H link bond [27].…”

Section: Discussionmentioning

confidence: 99%

Extraction, Structural Characterization, and Potential Antioxidant Activity of the Polysaccharides from Four Seaweeds

Chen

et al. 2016

IJMS

106

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Four seaweed polysaccharides were extracted from Sarcodia ceylonensis, Ulva lactuca L., Gracilaria lemaneiformis, and Durvillaea antarctica, respectively, by microwave-assisted extraction. The effect of three significant variables (extraction time, extraction temperature, and the ratio of water to raw material) on the process for extracting polysaccharides was investigated, along with the optimization of the extraction using the response surface method (RSM) with a Box–Behnken design. The polysaccharide structure, monosaccharide composition, degree of sulfation, and molecular weight (MW) distribution were analyzed by infrared (IR) spectrometry, gas chromatography (GC), and high-performance gel permeation chromatography (HPGPC). IR spectrometry showed that Sarcodia ceylonensis polysaccharide (SCP), Ulva lactuca L. polysaccharide (ULLP), and Durvillaea antarctica polysaccharide (DAP) were all sulfated polysaccharides and, except Gracilaria lemaneiformis polysaccharide (GLP), all belong to β-pyranosidic polysaccharides. The average molecular weight (MW) of SCP, ULLP, GLP, and DAP was 466, 404, 591, and 482 kDa, respectively. The quantitative and comparative results with external standards indicated that the main monosaccharide in SCP and ULLP was mannose; and GLP and DAP were mainly composed of galactose and glucose, respectively. Then the in vitro antioxidant activity of all of the polysaccharides was evaluated using different assays—2,2–azino –bis (3-ethylbenzthiazoline-6- sulfonate) (ABTS), hydroxyl radical, nitrite scavenging capacity, and reducing power—and the relationship between their antioxidant activity and chemical characteristics were also examined. ULLP presented the highest ABTS radical scavenging activity; ULLP, SCP and DAP also showed a strong effect on the ABTS radical scavenging activity. SCP and ULLP exhibited excellent hydroxyl radical scavenging activities, about 83.33% ± 2.31% and 80.07% ± 2.17%, respectively, at 4 mg/mL. The reducing power of DAP was relatively more pronounced than that of the three other polysaccharides. However, the nitrite scavenging activities of the four seaweed polysaccharides were weaker than other antioxidant activity (ABTS), hydroxyl radical scavenging capacity, and reducing power. In addition, GLP exhibited lower activities than the other three samples in all of the tests for the antioxidant activity.

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Section: Discussionmentioning

confidence: 99%

Extraction, Structural Characterization, and Potential Antioxidant Activity of the Polysaccharides from Four Seaweeds

Chen

et al. 2016

IJMS

106

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“…Several polysaccharides were found to have good anti-inflammatory and hepatic activity1516, however, limited by low yield and low activity, it is thus necessary to find a way to strengthen the bioactivities of polysaccharides17. Meanwhile, the introduction of sulfated groups has been reported to significantly improve the bioactivity of polysaccharides, including the antioxidant and anti-inflammatory activities1819. After sulfated modification, modified polysaccharides could better improve inflammatory condition of macrophages through decreasing phagocytosis activity and NO production15.…”

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confidence: 99%

“…After sulfated modification, modified polysaccharides could better improve inflammatory condition of macrophages through decreasing phagocytosis activity and NO production15. Sulfated fugal polysaccharides from Antrodia cinnamomea had a stronger inhibitory effect on TNF-α and IL-6 production as compared with native polysaccharides19. Sulfated polysaccharides also contributed to anti-LPS induced oxidative stress in liver, an important immune and digestive organ20.…”

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confidence: 99%

Sulfated Cyclocarya paliurus polysaccharides markedly attenuates inflammation and oxidative damage in lipopolysaccharide-treated macrophage cells and mice

Wang

Xie

Yang

et al. 2017

Sci Rep

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Natural polysaccharides and their modified derivatives are crucial supplements to the prevention of inflammation. This study aimed to evaluate the effect of sulfated modification on the anti-inflammatory and anti-oxidative activities of Cyclocarya paliurus polysaccharides (CP). A sulfated CP, S-CP1–4 was obtained using chlorosulfonic acid-pyridine method. The chemical components and FT-IR spectrum confirmed that sulfated group was synthesized to the polysaccharide chains successfully. S-CP1–4 was found to inhibit nitric oxide production, phagocytic activity and the release of interleukin (IL)-6 and IL-1β in lipopolysaccharide-treated macrophage cells, RAW 264.7. S-CP1–4 significantly decreased the secretion of IL-6 and TNF-α and the thymus and spleen indexes, and increased the production of IL-10 in lipopolysaccharide-treated mice. S-CP1–4 could better protect the liver by inhibiting the activities of alanine aminotransferase and aspartate aminotransferase, and malondialdehyde level while increasing the superoxide dismutase activity and total anti-oxidative capacity. These results suggested that S-CP1–4 may be an effective anti-inflammatory agent, and sulfated modification may be a reliable method for the development of food supplements.

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“…It has been demonstrated that some natural polysaccharides exhibit obvious anti-inammatory activities by inhibiting the production of inammatory cytokines in cell or mouse models. 9,10 It is important to be able to efficiently extract these bioactive polysaccharides for their application or further research. Conventionally, polysaccharides are extracted from plant tissues by heating, boiling, or reuxing methods.…”

Section: Introductionmentioning

confidence: 99%

Optimization of the extraction, preliminary characterization, and anti-inflammatory activity of crude polysaccharides from the stems of Trapa quadrispinosa

Feng

Liu²,

et al. 2019

RSC Adv.

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Studies on anti-inflammatory activity of sulfated polysaccharides from cultivated fungi Antrodia cinnamomea

Cited by 76 publications

References 29 publications

Extraction, Structural Characterization, and Potential Antioxidant Activity of the Polysaccharides from Four Seaweeds

Extraction, Structural Characterization, and Potential Antioxidant Activity of the Polysaccharides from Four Seaweeds

Sulfated Cyclocarya paliurus polysaccharides markedly attenuates inflammation and oxidative damage in lipopolysaccharide-treated macrophage cells and mice

Optimization of the extraction, preliminary characterization, and anti-inflammatory activity of crude polysaccharides from the stems of Trapa quadrispinosa

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