Studies on anti-hepatoma activity of Annona squamosa L. pericarp extract

Chen, Ya-yun; Cao, Yuzhu; Li, Fuqiang; Zhu, Xiaoli; Peng, Chen-xiao; Lü, Jiahui; Chen, Jianwei; Li, Xiang; Chen, Yong

doi:10.1016/j.bmcl.2017.03.036

Cited by 11 publications

(7 citation statements)

References 27 publications

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“…Thus, moderate antiproliferative activities (IC 50 > 30 μg/ml) had been observed with methanol extracts of leaves, bark, and root of V. paradoxa on the human hepatocarcinoma cell line HepG2 (Mbaveng et al, 2011). Pericarp and seed extracts from Annona squamosa showed anti-hepatocarcinoma activity on HepG2 cells in vitro (IC 50 of 0.36 μg/ml) as well as an anti-hepatoma activity in vitro and in vivo in transplanted tumor H(22) cells in mice (Chen et al, 2012;Chen et al, 2017). Moreover, although not mentioned by healers to be useful against liver cancer, anti-liver cancer properties were found with the fermented preparation of fruits of Carica papaya L. when hepatocarcinoma was induced by N-methyl-Nnitrosourea in mice (Somanah et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Countrywide Survey of Plants Used for Liver Disease Management by Traditional Healers in Burkina Faso

et al. 2020

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Liver disease is highly prevalent in Africa, especially in the western African country Burkina Faso, due to the presence of multiple biological and chemical aggressors of the liver. Furthermore, diagnosis and appropriate care for liver disease are uneven and usually insufficient. This drives local communities to turn to folk medicine based on medicinal plants from healers. Small scale, ethnopharmacological studies on reputed hepatoprotective plants have been carried out in defined regions worldwide, but so far, no study has been carried out on a countrywide scale. Therefore, we have explored traditional healers’ practices in all thirteen regions of Burkina Faso. We interviewed 575 healers and we compiled a database with 2,006 plant entries. Here, we report results on liver nosology, liver pathologies, medicinal plants used for liver disease, and traditional practices through the lens of Burkinabe healers. Our goal was to give a full inventory of medicinal plants used to treat liver disease and to determine if there was consensus on the use of specific plants for specific symptoms. Analysis of the medicinal plants in use across the whole country provides local communities with a wider evidence base to determine which plants may be more effective in treating liver disease and could provide the scientific community, with a shortlist of plants suitable for chemical and pharmacological investigation to validate the plants’ therapeutic role.

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Section: Discussionmentioning

confidence: 99%

Countrywide Survey of Plants Used for Liver Disease Management by Traditional Healers in Burkina Faso

et al. 2020

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“…The seeds’ hemolytic property may be associated with the presence of annonaceous acetogenins in large amounts, the main compounds of their chemical constitution, which have been explored for the treatment of different types of cancers and in the fight against certain pests ( Chen et al, 2017 ). The toxicity of acetogenins was first reported in 1991.…”

Section: Discussionmentioning

confidence: 99%

Influence of methanolic extracts from seeds and pulp of Annona squamosa L. on osmotic and morphological fragility in human erythrocytes

Leite¹,

Camilo²,

Castro³

et al. 2023

Current Research in Toxicology

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“…Equivalente a ação das folhas, a polpa da fruta do conde também apresenta ação antiglicêmica, pois a pinha parece desenvolver o mesmo papel da insulina, estimulando a sua produção e aumentando a captação de glicose pelos músculos, o que leva à estabilização das concentrações de açúcar no sangue (NAIR; AGRAWAL, 2017). A polpa também apresenta efeito antitumoral contra tumores hepáticos (CHEN et al, 2017), alta atividade antioxidante e antidiabetogênica (NANDHAKUMAR;INDUMATHI, 2013;MOHD et al, 2009, PARDHASARADHI et al, 2005PARDHASARADHI et al, 2004). Além disto, apresenta capacidade imunoreguladora (TU et al, 2016), e atua inibindo a atividade da α-glicosidase (REN et al, 2017).…”

Section: Folhasunclassified

FRUTA DO CONDE E SAÚDE (Annona squamosa, L.): UMA BREVE REVISÃO

Radünz

Camargo

Ribeiro

et al. 2019

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A busca por uma alimentação saudável e que ocasione a promoção da saúde vêm aumentando nos últimos anos, e, neste sentido, as frutas e hortaliças recebem destaque, já que seu consumo está associado com a menor incidência de diversas doenças. Dentre as frutas que possuem estes benefícios está a fruta do conde (Annona squamosa, L.), que é produzida principalmente na região nordeste do Brasil. A mesma é rica em compostos fenólicos, terpenos, e as acetogeninas, ácidos graxos de cadeia muito longa exclusivas da família Annonaceous. Estes compostos são responsáveis por diversas atividades atribuídas à fruta, como atividade antioxidante, antimicrobiana, anticarcinogênica, anti-hipertensiva, antidiabética, imunossupressora, além amenizar os sintomas do hipotireoidismo, comprovando, assim, que o seu consumo é extremamente recomendável e benéfico ao organismo humano.

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Studies on anti-hepatoma activity of Annona squamosa L. pericarp extract

Cited by 11 publications

References 27 publications

Countrywide Survey of Plants Used for Liver Disease Management by Traditional Healers in Burkina Faso

Countrywide Survey of Plants Used for Liver Disease Management by Traditional Healers in Burkina Faso

Influence of methanolic extracts from seeds and pulp of Annona squamosa L. on osmotic and morphological fragility in human erythrocytes

FRUTA DO CONDE E SAÚDE (Annona squamosa, L.): UMA BREVE REVISÃO

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