Studies on anaerobic bacteria in chronic otitis media

Sugita, Rinya; Kawamura, Shozo; Ichikawa, Ginichiro; Goto, Shigeo; Fujimaki, Yutaka

doi:10.1288/00005537-198105000-00016

Cited by 30 publications

(9 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…from a significant proportion of all cases of otitis media (e.g., 7,17,19). Polymicrobic infection florae (many including anaerobic bacteria) are found in some others, especially in recurrent acute and in chronic otitis media (1,2,6,18,33). The role of other isolates from cases of otitis media is uncertain, the etiology of otitis media remains incompletely defined (13,27), and recent symposia on otitis media call for further study of the etiology of the disease (27).…”

mentioning

confidence: 99%

Experimental otitis media in gerbils and chinchillas with Streptococcus pneumoniae, Haemophilus influenzae, and other aerobic and anaerobic bacteria

Fulghum¹,

Brinn²,

Smith³

et al. 1982

Infect Immun

View full text Add to dashboard Cite

To ascertain the usefulness of Mongolian gerbils as an inbred model for otitis media, 52 Mongolian gerbils (Meriones unguiculatus, strain MON/Tum) were compared with 26 chinchillas (Chinchilla laniger) for susceptibility to Streptococcus pneumoniae type 3, Haemophilus influenzae type b, and a polymicrobic culture including anaerobes (Streptococcus intermedius, Propionibacterium acnes, Staphylococcus epidermidis, and Corynebacterium sp.). Organisms were inoculated percutaneously into the superior chamber of the middle ear bulla. The gerbils and chinchillas shared similar susceptibilities and responses to the inoculated organisms as determined by X-ray, otoscopic, histopathological, and microbiological determinations at 5 to 7 days. Koch's postulate studies proved the role of S. pneumoniae and H. influenzae in the pathology found in both animal models. The animals were also susceptible to the polymicrobic culture, although the relative virulence of the individual members of this mixture was low, suggesting that these species potentiated as a polymicrobic mixture. The Corynebacterium sp. appeared to elicit the greatest histopathological response in chronic (8-week) studies in gerbils. The gerbils were found to be useful as an alternative animal model for the study of otitis media of bacterial etiology. bils to otitis media when inoculated with Streptococcus pneumoniae type 3, H. influenzae type 802 on July 16, 2020 by guest

show abstract

mentioning

confidence: 99%

Experimental otitis media in gerbils and chinchillas with Streptococcus pneumoniae, Haemophilus influenzae, and other aerobic and anaerobic bacteria

Fulghum¹,

Brinn²,

Smith³

et al. 1982

Infect Immun

View full text Add to dashboard Cite

show abstract

“…Several important factors influence the chronicization of otitis media (OM) [6]; the most common and important of which is the infection by bacterial microorganisms. Bacteria entering the middle ear cause irritation to the mucosa of the middle ear, which causes the TM and the ossicles to become increasingly injured [7][8][9]. As the disease progresses through the perforation of the TM, the hearing level is aggravated, and inflammation spreads over the bones surrounding the middle ear [9,10].…”

Section: Introductionmentioning

confidence: 99%

Intra-Operative Optical Coherence Imaging of In-Vivo Chronic Otitis Media Followed by Post-Operative Audiogram Assessments

Kim

Lee

Wijesinghe

et al. 2021

IEEE J. Select. Topics Quantum Electron.

View full text Add to dashboard Cite

The successful surgery of chronic otitis media (COM) is challenging; this depends on the surgeon's knowledge of the optical visibility of surgical microscopes. Herein, we reported the utilization of intra-surgical optical coherence tomography (OCT) system to effectively guide the surgery of COM based on augmented reality with cross-sectional images. The intra-surgical spectral-domain OCT system with a center wavelength of 846 nm was capable of obtaining non-invasive, high-resolution, and highspeed visualizations with an axial resolution of 8 m, lateral resolution of 30 m, and an extended working distance of 280 mm. Three patients with COM were involved in this research. The lesion conditions of the temporal bone were observed with computed tomography pre-operatively. Furthermore, pure-tone audiogram examinations were performed to evaluate pre and postsurgical conditions. The results revealed that the averaged airbone gap of 500 Hz, 1 kHz, 2 kHz, and 4 kHz in all cases improved to 61%. Thus, the research proves that the experimental procedure can be beneficial and clinically applicable with the developed intra-surgical OCT system for future otolaryngological assessments.

show abstract

“…1,2 The prevalence of granulations in chronic otitis media (COM) was found to be as high as 97 per cent in the 144 temporal bones studied by Da Costa et al 2 Several authors have advocated clearing the mastoid of granulations prior to closure of a perforation and at the same time making the aditus patent, thus providing a reservoir of air to prevent retraction of the neotympanum. [3][4][5][6] Although ear discharge has been widely researched, [7][8][9][10][11][12] there is a paucity of studies on bacteriology of mastoid granulation tissue. 13 In as early as 1965, Palva et al in their bacteriological study of chronic suppurative otitis media (CSOM), analysed flora from middle-ear aspirates preoperatively, fluid in the mastoid or antral tissue intraoperatively as well as exudates from the canal postoperatively.…”

Section: Introductionmentioning

confidence: 99%

Outcome of bacterial culture from mastoid granulations: is it relevant in chronic ear disease?

et al. 2005

View full text Add to dashboard Cite

In this study, we found that mastoid granulations are not sterile but harbour polymicrobial pathogens. Positive cultures were obtained irrespective of stage of disease activity, age, duration of disease and aditus patency. The pattern of organisms cultured from safe and unsafe CSOM and also from ears in active, quiescent and inactive stages, were similar. These findings suggest that these organisms may be responsible for mastoid granulations. We also noted that positive cultures had no statistical correlation with aditus patency and duration of disease. We suggest further studies to evaluate the significance of asymptomatic mastoid granulations harbouring organisms and whether opening the mastoid antrum and achieving aditus patency, irrespective of the stage of disease activity, will help improve the long-term surgical outcome and also prevent recurrence of ear discharge.

show abstract

Studies on anaerobic bacteria in chronic otitis media

Cited by 30 publications

References 9 publications

Experimental otitis media in gerbils and chinchillas with Streptococcus pneumoniae, Haemophilus influenzae, and other aerobic and anaerobic bacteria

Experimental otitis media in gerbils and chinchillas with Streptococcus pneumoniae, Haemophilus influenzae, and other aerobic and anaerobic bacteria

Intra-Operative Optical Coherence Imaging of In-Vivo Chronic Otitis Media Followed by Post-Operative Audiogram Assessments

Outcome of bacterial culture from mastoid granulations: is it relevant in chronic ear disease?

Contact Info

Product

Resources

About