Studies of Tubercle Bacillus-Histiocyte Relationships

Fong, Jacob; Chin, Dennis; Elberg, Sanford S.

doi:10.1084/jem.118.3.371

Cited by 36 publications

(5 citation statements)

References 21 publications

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“…Recent reports on the passive transfer of acquired resistance in tuberculosis (7,8,11,12,34,36) can also be recognized as presentations of the cellular nature of immunity.…”

Section: Discussionmentioning

confidence: 99%

The Use of Diffusion Chambers in Investigating the Cellular Nature of Immunity in Experimental Typhoid and Tuberculosis

Akiyama

Maeda

Asaba

et al. 1964

Japanese Journal of Microbiology

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“…Recent reports on the passive transfer of acquired resistance in tuberculosis (7,8,11,12,34,36) can also be recognized as presentations of the cellular nature of immunity.…”

Section: Discussionmentioning

confidence: 99%

The Use of Diffusion Chambers in Investigating the Cellular Nature of Immunity in Experimental Typhoid and Tuberculosis

Akiyama

Maeda

Asaba

et al. 1964

Japanese Journal of Microbiology

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“…Detailed descriptions of procedures and materials used in these studies have been described in earlier reports (1)(2)(3)(4)(5)(6) and are therefore briefly described herein.…”

Section: Methodsmentioning

confidence: 99%

“…The method of extraction of RNA from ribosomes was that described by Gierer and Schramm (9). Application of these procedures to histioeytes has been described previously (5).…”

Section: Methodsmentioning

confidence: 99%

“…Resistance in Normal Animals.--Previous investigations (4,5) have shown that the resistance of hisfiocytes against virulent tubercle bacilli was transferable to normal animals by injections of immune histiocytes or of ribosomes and ribosomal RNA derived from the immune histiocytes. It therefore seemed reasonable that if the mechanism of resistance of Brucella-immune cells resembled that of the BCG-immune cells, transference to normal animals of immunity against Brucella should be similarly achievable.…”

Section: Inability Of Brucdla-immune Histiocytes and Ribosomes To Indmentioning

confidence: 99%

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Studies of Tubercle Bacillus-Histiocyte Relationships

Fong

Chin

Elberg

1964

The Journal of Experimental Medicine

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Earlier reports (1, 2) from this laboratory have shown that immunization of animals with the BCG strain of tubercle bacillus resulted in the development of resistant populations of histiocytes in these animals; this form of cellular resistance was manifested by the refractoriness of infected immune histiocytes to necrotization by virulent tubercle bacilli (H37Rv strain). The expression of such resistance was, however, dependent upon the presence of some non-specific factor present in homologous and heterologous immune sera (e.g. anti-BCG, antiovalbumin, anti-Salmonella sera).Further studies (3) have shown that a similar type of cellular resistance was demonstrable with the histiocytes of rabbits immunized with the Rev I strain of Brucella mel/tens/s. There was, moreover, a state of cross-immunity between the Brucella-immune (from animals immunized with Rev I) and the BCG-immune (from animals immunized with BCG) histiocytes such that infection of one or the other of the two histiocytes with either the homologous or heterologous pathogen did not result in destruction of cells by the parasite. An obvious inference which may be drawn from this observation is the probable identity of the mechanism or mechanisms for this type of cellular resistance.Since the above findings have been reported, additional characterization of the tubercle bacillus-histiocyte model system has been achieved (4--6). It is now known that cellular resistance against mycobacteria can be induced in normal animals by injections of immune histiocytes, recipient histiocytes (histiocytes of normal animals which had been injected with resistant cells), and by immune ribosomes and ribosomal RNA (ribonucleic acid). It is also an established fact that serial transfer of resistance in normal animals against mycobacteria is achievable by injection of animals with resistant histiocytes or subfractions (ribosomes) derived therefrom. Moreover, it has been shown that passage of virulent tubercle bacilli in immune histiocytes resulted in attenuation of bacilli for both mice and normal histiocytes (i.e. passaged bacilli lose their inherent ability to necrotize the histiocytes of normal animals).In view of the above findings, it seemed propitious to investigate the identity or lack of identity of the basic mechanisms which underlie cellular immunity

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“…It was reported from this [10,[14][15][16][17][18][19][20] and other laboratories [1][2][3][4][5][6][7] that a ribonucleic acid (RNA) preparation extracted from peritoneal exudate cells or spleens of immunized animals was capable of transferring immune response either in vitro or in vivo to non-immunized cells.…”

mentioning

confidence: 99%

Transfer Agent of Immunity

Kurashige

Kïtamura

Akama

et al. 1970

Japanese Journal of Microbiology

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An immune ribonucleic acid (RNA) preparation was extracted with phenol from the spleens of guinea pigs immunized with diphtheria toxoid. Antibody-carrying cells were detected by immunocyte adhesion as rosette-forming cells. When germ-free rats, conventional guinea pigs or mice were injected intraperitoneally with this preparation, the rosette-formers were detected in either peritoneal exudate cells or spleen cells, whereas serum antibodies were unable to be detected thus far in such animals. Two injections with this preparation did not cause any remarkable increase in the number of rosetteformers, and serum antibody was also not detectable. By contrast, a high titer of serum antibody was demonstrated and the number of rosette-formers increased shortly after an injection of a small amount of diphtheria toxoid into guinea pigs which had previously received an injection with immune RNA. This reaction indicates a secondary response of antibody formation. However, secondary responses were not induced by injections of immune RNA preparations in guinea pigs primed with either diphtheria toxoid or immune RNA preparation. These facts suggest that immune RNA preparations did not contain antigens or fragments thereof and the immune response induced by RNA preparation is not the same as that induced by stimulation by the antigen itself. These results moreover can be accounted for by the notion that the immune RNA preparation is able to induce "memory" cells capable of responding to a secondary stimulus with an antigen and producing a high titer of serum antibody.

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Studies of Tubercle Bacillus-Histiocyte Relationships

Cited by 36 publications

References 21 publications

The Use of Diffusion Chambers in Investigating the Cellular Nature of Immunity in Experimental Typhoid and Tuberculosis

The Use of Diffusion Chambers in Investigating the Cellular Nature of Immunity in Experimental Typhoid and Tuberculosis

Studies of Tubercle Bacillus-Histiocyte Relationships

Transfer Agent of Immunity

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