Studies of the labile lead pool using a rhodamine-based fluorescent probe

Zhu, Jianping; Yeo, Jia Hao; Bowyer, Amy A.; Proschogo, Nicholas; New, Elizabeth J.

doi:10.1039/d0mt00056f

Cited by 5 publications

(2 citation statements)

References 48 publications

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“…Rhodamine and rhodamine derivatives have been applied widely as fluorescent probes owing to their remarkable optical characteristics including a high fluorescence quantum yield (Φ), a large molar extinction coefficient (ε), and longer excitation and emission wavelengths. 31 So far, many fluorescent probes utilizing rhodamine derivatives had been utilized to sense different cations including Cu 2+ , 32 Pb 2+ , 33 Cr 3+ , 34 Fe 3+ , 35 Al 3+ , 36 Zn 2+ , 37 and so forth. The sensing mechanism of these probes for cations is based on the transformation from a spirocyclic form into an open cyclic structure.…”

Section: Introductionmentioning

confidence: 99%

Rhodamine-Based Fluorescent Probe for Highly Selective Determination of Hg²⁺

Zhu

et al. 2022

ACS Omega

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The determination of mercuric ions (Hg 2+ ) in environmental and biological samples has attracted the attention of researchers lately. In the present work, a novel turn-on Hg 2+ fluorescent probe utilizing a rhodamine derivative had been constructed and prepared. The probe could highly sensitively and selectively sense Hg 2+ . In the presence of excessive Hg 2+ , the probe displayed about 52-fold fluorescence enhancement in 50% H 2 O/CH 3 CH 2 OH (pH, 7.24). In the meantime, the colorless solution of the probe turned pink upon adding Hg 2+ . Upon adding mercuric ions, the probe interacted with Hg 2+ and formed a 1:1 coordination complex, which had been the basis for recognizing Hg 2+ . The probe displayed reversible dual colorimetric and fluorescence sensing of Hg 2+ because rhodamine’s spirolactam ring opened upon adding Hg 2+ . The analytical performances of the probe for sensing Hg 2+ were also studied. When the Hg 2+ concentration was altered in the range of 8.0 × 10 –8 to 1.0 × 10 –5 mol L –1 , the fluorescence intensity showed an excellent linear correlation with Hg 2+ concentration. A detection limit of 3.0 × 10 –8 mol L –1 had been achieved. Moreover, Hg 2+ in the water environment and A549 cells could be successfully sensed by the proposed probe.

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Section: Introductionmentioning

confidence: 99%

Rhodamine-Based Fluorescent Probe for Highly Selective Determination of Hg²⁺

Zhu

et al. 2022

ACS Omega

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“…Over the past decade, quantification of brain tissue copper contents has primarily employed biophysical techniques, such as inductively coupled plasma mass spectrometry (ICP-MS), , which requires destructive digestion of the tissue sample before measurement. Synchrotron radiation X-ray fluorescence microscopy (SRXFM) and particle induced X-ray emission (PIXE) microscopy have been used to quantify copper levels at the single cell level in tissue sections in Parkinson disease brain .…”

mentioning

confidence: 99%

Near-Infrared Ratiometric Fluorescent Probe for Detecting Endogenous Cu²⁺ in the Brain

Zhu,

Graziotto,

Cottam

et al. 2024

ACS Sens.

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Copper participates in a range of critical functions in the nervous system and human brain. Disturbances in brain copper content is strongly associated with neurological diseases. For example, changes in the level and distribution of copper are reported in neuroblastoma, Alzheimer's disease, and Lewy body disorders, such as Parkinson disease and dementia with Lewy bodies (DLB). There is a need for more sensitive techniques to measure intracellular copper levels to have a better understanding of the role of copper homeostasis in neuronal disorders. Here, we report a reaction-based near-infrared (NIR) ratiometric fluorescent probe CyCu1 for imaging Cu 2+ in biological samples. High stability and selectivity of CyCu1 enabled the probe to be deployed as a sensor in a range of systems, including SH-SY5Y cells and neuroblastoma tumors. Furthermore, it can be used in plant cells, reporting on copper added to Arabidopsis roots. We also used CyCu1 to explore Cu 2+ levels and distribution in post-mortem brain tissues from patients with DLB. We found significant decreases in Cu 2+ content in the cytoplasm, neurons, and extraneuronal space in the degenerating substantia nigra in DLB compared with healthy age-matched control tissues. These findings enhance our understanding of Cu 2+ dysregulation in Lewy body disorders. Our probe also shows promise as a photoacoustic imaging agent, with potential for applications in bimodal imaging.

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