Studies of the esterification of dextran: routes to bioactive polymers and graft copolymers

Macromolecular design and application using Mn2(CO)10‐based visible light photoinitiating systems

“…The halogenated products were utilized in the graft copolymerization of vinyl monomers under UV or visible light irradiation at 25 ∘ C. High grafting yields between 600% and 1380% were attained. 96 -98 Recently, Buchmeiser and Yagci described multi-mode approaches for the preparation of various graft copolymers by combination of either ring-opening metathesis polymerization (ROMP), hydrobromination and Mn 2 (CO) 10 -mediated free radical polymerization or ROMP, hydrobromination and Mn 2 (CO) 10 -mediated free radical promoted cationic polymerization. In the first step of the method, cis-cyclooctene was polymerized via ROMP in the presence of a chain transfer agent and quantitatively hydrobrominated to obtain a pendent bromide containing linear poly(ethylene).…”

“…94 Pendent CCl 3 containing polycarbonates prepared by condensation polymerization of bisphenol A and 1,1,1-trichloro-2,2-bis(4-hydroxyphenylethane) were also utilized for the graft copolymerization of ACN using the Mn 2 (CO) 10 -based photoinitiating system. 95 Mn 2 (CO) 10 -mediated graft copolymerization has also been employed to attach various vinyl monomers such as methyl (meth)acrylate, 2-hydroxyethyl methacrylate, acrylamide or acrylic acid onto biopolymers (dextran 96 or chitosan 97 ). The dextran was halogenated by using 2-bromopropionic acid with the aid of dicyclohexyl carbodiimide, whereas the chitosan was halogenated by trichloroacetic anhydride in the presence of sodium bicarbonate.…”

Modification of Biomaterials to Improve Blood Compatibility

“…R=Ph) to yield the polymer-BW 245C adduct shown in [6). This represents a portion of the polymer chain; the proportions of BW 245C and vinyl monomer units are [5) [12] to the urethane linkages and used as free radical sources (with the aid of the metal carbonyl processes already outlined) (18,19) to graft on the BW 245C-monomer ( [5], n=1) and DI MA [11] and many other species. Interesting monomers [14], [15], have been prepared from several a-amino acids and also from amino sugars, e.g.…”

“…Two reagents which have proved very effective for such purposes are haloisocyanates (more properly called halo-alkyl isocyanates or halo acylisocyanates), two examples of which are shown in [12] and 2-isocyanatoethyl methacrylate [13].…”

Routes to Bioactive Hydrophilic Polymers

“…Route 2 is conveniently carried out as a two-stage process 6 and we have used it for coupling theophylline ((13), R=H), an inhib- itor of phosphodiesterase, via an ester linkage. For this purpose theophylline was converted to theophylline-7-acetic acid ((13) R = CH 2 COOH).…”