Studies of the Effect of X‐Rays on the β‐Glucuronidase Activity in the Gastric Mucous Membrane and in the Liver and of its Relation to the Glucuronide Conjugation

Hartiala, K.; Näuntö, V.; Rinne, U. K.; Savola, Petter

doi:10.1111/j.1748-1716.1960.tb01930.x

Cited by 5 publications

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“…The local X-ray irradiation was performed in Nembutal anesthesia, the duodenum was exposed through a mid-line excisiori, and the animal protected with a 3 mm lead shield. The local X-ray irradiation was performed by single 400 r (group A) and 1,200 r (group B) doses (185 kV X-ray machine, 10 mA, 0.5 cm Cu), as described previously (HARTIALA, NANTO and RINNE 1958, 1959and HARTIALA et al 1960.Prior to and after the operation and irradiation the animals were fed with usual laboratory diet and water ad libitum. All of the animals survived for the later analyses.…”

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Studies of the Effect of X‐Rays on the Glucuronide Synthesis and β‐Glucuronidase Activity in the Duodenal Mucous Membrane of the Rat

Hartiala

Nántö

Rinne

1961

Acta Physiologica Scandinavica

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In a series of previous experiments we have studied the effect of local X‐ray irradiation on the glucuronide conjugation capacity and on the p‐glucuronidase activity of the liver and gastric mucosa. According to these studies the sensitivity of these tissues towards irradiation is different. These studies also show that the changes in the glucuronide formation capacity and the β‐glucuronidase activity are not parallel which is taken as a further indication that the β‐glucuronidase enzyme is not involved in the synthesis of glucuronide‐conjugates. In the present work we have studied the glucuronide conjugation and β‐glucuronidase activity of rat duodenal mucosa after local X‐ray irradiation.

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confidence: 99%