Studies of the Blood-Aqueous Barrier in Diabetes Mellitus

Moriarty, A P; Spalton, David J.; Moriarty, Brendan; Shilling, J S; Ffytche, T. J.; Bulsara, Max

doi:10.1016/s0002-9394(14)70320-4

Cited by 75 publications

(40 citation statements)

References 12 publications

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“…Breakdown of the blood-ocular barrier in diabetic eyes, particularly in eyes with DR, is known to be greater than that in nondiabetic eyes. [40][41][42] Indeed, the mean intensity of flare in the DR group was significantly greater than that in the no DR group throughout the follow-up (unpublished data). Accordingly, macular thickening may be more pronounced in eyes with DR.…”

Section: Eyementioning

confidence: 87%

Changes in diabetic macular oedema after phacoemulsification surgery

Hayashi

Igarashi

Hirata

et al. 2007

Eye

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Purpose To quantitatively examine changes in macular oedema after phacoemulsification surgery in eyes with diabetic retinopathy (DR) and in eyes without DR. Methods Thirty-four eyes with DR and 34 eyes with no DR scheduled for phacoemulsification surgery were recruited. Foveal thickness and macular volume were measured using optical coherence tomography preoperatively and at 3, 6, and 12 months postoperatively. Grade of diabetic macular oedema was also examined. Results Preoperatively, there were no significant differences between groups in foveal thickness and macular volume. The foveal thickness increased by 20.3% in the DR group and by 6.0% in the no DR group at 3 months after surgery, but thereafter decreased gradually. When comparing the groups, the foveal thickness and macular volume were significantly greater in the DR group than in the no DR group at 3 months postoperatively. The grade of macular oedema worsened in eight eyes (23.5%) in the DR group, and in one (2.9%) in the no DR group: the incidence was significantly greater in the DR group (P ¼ 0.0272). However, the oedema that occurred after surgery resolved spontaneously in three (33.3%) of the nine eyes. Conclusions The degree of diabetic macular oedema increases up to 3 months after cataract surgery, but thereafter decreases gradually. Grade of diabetic macular oedema also worsens up to 3 months, but certain percent of macular oedema that occurs after surgery resolves spontaneously. These changes are more prominent in eyes with DR than in eyes with no DR.

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Section: Eyementioning

confidence: 87%

Changes in diabetic macular oedema after phacoemulsification surgery

Hayashi

Igarashi

Hirata

et al. 2007

Eye

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“…Increased values of AGEs in the vitreous in patients with PDR seem to be related to breakdown of the BRB. Furthermore, some authors reported that permeability of the bloodaqueous barrier (BAB) increased in patients with PDR (22,23). We speculated that increased corneal AGEs in patients with PDR may be caused by an increase of AGEs in the aqueous humor and vitreous resulting from breakdown of the BRB and/or BAB.…”

Section: Discussionmentioning

confidence: 97%

Corneal Advanced Glycation End Products Increase in Patients With Proliferative Diabetic Retinopathy

et al. 2001

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OBJECTIVE—To evaluate corneal advanced glycation end product (AGE) fluorescence in patients with diabetes and in healthy control subjects. RESEARCH DESIGN AND METHODS—Corneal autofluorescence was measured in 26 eyes of 26 patients with type 2 diabetes (mean age 57.0 years; mean disease duration 12.2 years; mean HbA1c 7.1%) and 13 eyes of 13 healthy age-matched control subjects (mean age 57.9 years). The patients with type 2 diabetes were divided into the following groups: patients without diabetic retinopathy (DR), patients without proliferative diabetic retinopathy (PDR), and patients with PDR. Corneal autofluorescence was measured by fluorophotometry with the wavelength that is characteristic of AGE fluorescence (excitation and emission 360–370 nm and 430–450 nm, respectively). We defined peak corneal autofluorescence levels as corneal AGE fluorescence values. We compared the corneal AGE fluorescence values in the four groups. RESULTS—In the PDR group (11.9 ± 3.9 arbitrary units [mean ± SD]), the corneal AGE fluorescence values were significantly higher compared with the control subjects (6.9 ± 1.3 arbitrary units), the patients without DR (7.4 ± 2.1 arbitrary units), and the patients without PDR (6.9 ± 2.2 arbitrary units) (P < 0.05). CONCLUSIONS—We found that corneal AGEs may increase in patients with diabetes and PDR compared with control subjects, patients without DR, and patients without PDR. In the patients with PDR, increased corneal AGEs may play a role in diabetic keratopathy.

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“…LFP studies have also displayed an increase in aqueous flare values in a variety of noninflammatory posterior segment disorders such as diabetic retinopathy, retinal vein occlusion and retinitis pigmentosa [49][50][51][52]. Flare intensity is correlated with the severity of diabetic retinopathy [52].…”

Section: Nonuveitic Conditionsmentioning

confidence: 99%